Expression of transgenes in midbrain dopamine neurons using the tyrosine hydroxylase promoter

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Gene Therapy

• Publication date

  2009-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/gt.2008.148PMID 18800154PMCID PMC2747767
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system

  2007cited by this paper
• Development of dopaminergic neurons in the mammalian brain

  2006cited by this paper
• Efferent projections of rat rostroventrolateral medulla C1 catecholamine neurons: Implications for the central control of cardiovascular regulation

  2006cited by this paper
• Genetic Tracing Shows Segregation of Taste Neuronal Circuitries for Bitter and Sweet

  2005cited by this paper
• Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice.

  2005cited by this paper
• Novel tracing paradigms--genetically engineered herpesviruses as tools for mapping functional circuits within the CNS: present status and future prospects.

  2004cited by this paper
• Cell specificity and efficiency of the Semliki forest virus vector- and adenovirus vector-mediated gene expression in mouse cerebellum.

  2004cited by this paper
• Viral vectors for gene delivery to the nervous system

  2003cited by this paper
• Adenovirus-mediated WGA gene delivery for transsynaptic labeling of mouse olfactory pathways.

  2002cited by this paper
• Visualizing selective neural pathways with WGA transgene: combination of neuroanatomy with gene technology.

  2002cited by this paper
• Genetic tracing reveals a stereotyped sensory map in the olfactory cortex

  2001cited by this paper
• A High-Efficiency Synthetic Promoter That Drives Transgene Expression Selectively in Noradrenergic Neurons

  2001cited by this paper
• Isolation of Highly Infectious and Pure Adeno-Associated Virus Type 2 Vectors with a Single-Step Gravity-Flow Column

  2001cited by this paper
• Current concepts in neuroanatomical tracing.

  2000cited by this paper
• Progress in Adeno-Associated Virus Type 2 Vector Production: Promises and Prospects for Clinical Use

  1999cited by this paper
• A Genetic Approach to Visualization Neurotechnique of Multisynaptic Neural Pathways Using Plant Lectin Transgene

  1999cited by this paper
• A genetic approach to trace neural circuits.

  1999cited by this paper
• A simplified system for generating recombinant adenoviruses.

  1998cited by this paper
• Identification of cell type-specific promoter elements associated with the rat tyrosine hydroxylase gene using transgenic founder analysis.

  1997cited by this paper
• Adenovirus-mediated gene transfer in olfactory neurons in vivo.

  1996cited by this paper
• Crossed connections of the substantia nigra in the rat

  1982cited by this paper

• AAV-only targeting of ventral tegmental area dopamine neurons for optical self-stimulation studies in mice

  2026cites this paper
• A Cross-Species Enhancer-AAV Toolkit for Cell Type-Specific Targeting Across the Basal Ganglia

  2026cites this paper
• MiniPromoters Ple384 (TH) and Ple388 (PITX3) for targeting midbrain dopaminergic neurons in mice and monkeys.

  2026cites this paper
• Adeno-associated viral vectors for modeling Parkinson’s disease in non-human primates

  2025cites this paper
• Inhibition of ventral tegmental area projections to the paraventricular thalamus attenuates conditioned cues-induced heroin seeking behavior in rats

  2025influential citation
• NA Comparison of Transduction Efficiency of Medial Septal Neurons by Adeno-Associated Viruses with Three Promoters.

  2025cites this paper
• Neuromodulator control of energy reserves in dopaminergic neurons

  2025cites this paper
• Regulation of working memory switches from striatal dopamine D2-receptor to D1-receptor neurons under high cognitive load

  2025influential citation
• Neuromodulatory control of energy reserves in dopaminergic neurons

  2025cites this paper
• Next-generation enhancer AAVs for selective interspecies targeting of midbrain dopaminergic neurons

  2025cites this paper
• Human TRPV1 is an efficient thermogenetic actuator for chronic neuromodulation

  2024cites this paper
• Gene therapy for neurotransmitter‐related disorders

  2024cites this paper
• Inhibition of repulsive guidance molecule-a protects dopaminergic neurons in a mouse model of Parkinson’s disease

  2021cites this paper
• α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability

  2021cites this paper
• Novel insights in the pathophysiology of α-synuclein dysregulation on D2 receptor activity contributing to the vulnerability of dopamine neurons

  2021cites this paper
• Activation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal death.

  2020cites this paper
• Optogenetic Modulation for the Treatment of Traumatic Brain Injury

  2020cites this paper
• Opposite Consequences of Tonic and Phasic Increases in Accumbal Dopamine on Alcohol-Seeking Behavior

  2020cites this paper
• AAV Capsid-Promoter Interactions Determine CNS Cell-Selective Gene Expression In Vivo.

  2020cites this paper
• Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission

  2020cites this paper
• Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression

  2019cites this paper
• Non-cell autonomous modulation of tyrosine hydroxylase by HMGB1 released from astrocytes in an acute MPTP-induced Parkinsonian mouse model

  2019cites this paper
• Optogenetics: Using Light to Investigate and Potentially Treat Neurological and Psychological Disorders

  2019cites this paper
• Columnar Injection for Intracerebral Cell Therapy.

  2019cites this paper
• Adeno-Associated Virus Technologies and Methods for Targeted Neuronal Manipulation

  2019cites this paper
• Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1

  2019influential citation
• Methods for analysis of brain connectivity: An IFCN-sponsored review.

  2019cites this paper
• Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans

  2018cites this paper
• Optogenetic manipulation of ENS ‐ The brain in the gut

  2018cites this paper
• VEGF Signaling in Neurological Disorders

  2018cites this paper
• MHC class I in dopaminergic neurons suppresses relapse to reward seeking

  2018cites this paper
• Spinal nociceptive circuit analysis with recombinant adeno‐associated viruses: the impact of serotypes and promoters

  2017cites this paper
• Resisting the Urge to Act: DREADDs Modifying Habits.

  2017cites this paper
• Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

  2017cites this paper
• A quantitative evaluation of a 2.5-kb rat tyrosine hydroxylase promoter to target expression in ventral mesencephalic dopamine neurons in vivo.

  2017influential citation
• Recombinant Adeno-Associated Virus-mediated rescue of function in a mouse model of Dopamine Transporter Deficiency Syndrome

  2017cites this paper
• Glutaredoxin-1 As A Therapeutic Target In Neurodegenerative Inflammation

  2017cites this paper
• α-Synuclein pathology and mitochondrial dysfunction: Studies in cell models for Parkinson’s disease

  2017cites this paper
• A Mechanistic Approach to the Development of Gene Therapy for Chronic Pain.

  2016cites this paper
• Transcriptional activity of novel ALDH1L1 promoters in the rat brain following AAV vector-mediated gene transfer

  2016cites this paper
• Optogenetic modulation in stroke recovery.

  2016cites this paper
• Cell-Specific Targeting of Genetically Encoded Tools for Neuroscience.

  2016cites this paper
• Methods to Understand Brain Connections and Neural Function Strategies for targeting primate neural circuits with viral vectors

  2016cites this paper
• Optogenetically-induced tonic dopamine release from VTA-nucleus accumbens projections inhibits reward consummatory behaviors.

  2016cites this paper
• Tissue-Specific Promoters in the CNS.

  2016cites this paper
• Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology.

  2016cites this paper
• Dopamine Neuron-Specific Optogenetic Stimulation in Rhesus Macaques

  2016cites this paper
• Neuroprotective potential of AAV-mediated NURR1 expression in a rat model of Parkinson’s disease

  2015cites this paper
• Targeted genetic manipulations of neuronal subtypes using promoter-specific combinatorial AAVs in wild-type animals

  2015influential citation
• Adeno-Associated Virus Vectors and Neurological Gene Therapy

  2015cites this paper
• Effects of α/β/γ-Synuclein overexpression on the mitochondria and viability of neurons, examined using genetically encoded fluorescent sensors

  2014cites this paper
• Role of catecholaminergic A2 neurons of nucleus of the solitary tract(NTS) in cardiovascular and respiratory adaptations to chronic intermittent hypoxia (CIH) in rats

  2014influential citation
• Dopamine: a parallel pathway for the modulation of spinal locomotor networks

  2014cites this paper
• Dopaminergic control of astrocytic calcium dynamics in situ and its potential effect on local synaptic activity

  2014influential citation
• A next step in adeno‐associated virus‐mediated gene therapy for neurological diseases: regulation and targeting

  2013cites this paper
• Optogenetic stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self-administration

  2013cites this paper
• Gene delivery with viral vectors for cerebrovascular diseases.

  2013cites this paper
• Regulated protein expression for in vivo gene therapy for neurological disorders: progress, strategies, and issues.

  2012cites this paper
• Avian Adeno-Associated Virus Vector Efficiently Transduces Neurons in the Embryonic and Post-Embryonic Chicken Brain

  2012cites this paper
• Optimization of a preparation of lentiviral particles for transduction of neurons in vivo

  2011cites this paper
• Specific connectivity and molecular diversity of mouse rubrospinal neurons

  2011cites this paper
• Evaluation of recombinant adenovirus-mediated gene delivery for expression of tracer genes in catecholaminergic neurons

  2010influential citation
• The role of functional postsynaptic NMDA receptors in the central nucleus of the amygdala in opioid dependence.

  2010cites this paper
• Gene transfer in the nervous system and implications for transsynaptic neuronal tracing

  2010cites this paper
• Transcriptional targeting to brain cells: Engineering cell type-specific promoter containing cassettes for enhanced transgene expression.

  2009cites this paper