Discovery of a Turn-On Fluorescent Probe for Myeloid Cell Leukemia-1 Protein.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Analytical Chemistry

• Publication date

  2017-10-16

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.analchem.7b01148PMID 29025262
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors.

  2017cited by this paper
• Virtual screening, SAR, and discovery of 5‐(indole‐3‐yl)‐2‐[(2‐nitrophenyl)amino] [1,3,4]‐oxadiazole as a novel Bcl‐2 inhibitor

  2017cited by this paper
• Rapid access to N-(indol-2-yl)amides and N-(indol-3-yl)amides as unexplored pharmacophores.

  2017cited by this paper
• Environment-Sensitive Fluorescent Probe for the Human Ether-a-go-go-Related Gene Potassium Channel

  2016cited by this paper
• Discovery of the First Environment-Sensitive Near-Infrared (NIR) Fluorogenic Ligand for α1-Adrenergic Receptors Imaging in Vivo.

  2016cited by this paper
• Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods.

  2016cited by this paper
• Protein recognition by bivalent, ‘turn-on’ fluorescent molecular probes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc01038a Click here for additional data file.

  2015cited by this paper
• Sensing Protein Surfaces with Targeted Fluorescent Receptors.

  2015cited by this paper
• A Fluorescent Probe for Imaging p53–MDM2 Protein–Protein Interaction

  2015cited by this paper
• Targeted protein surface sensors as a tool for analyzing small populations of proteins in biological mixtures.

  2014cited by this paper
• De Novo-Designed Enzymes as Small-Molecule-Regulated Fluorescence Imaging Tags and Fluorescent Reporters

  2014cited by this paper
• Environment-sensitive fluorescent turn-on probes targeting hydrophobic ligand-binding domains for selective protein detection.

  2013cited by this paper
• Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.

  2013cited by this paper
• The hallmarks of cancer

  2012cited by this paper
• Reaction-based small-molecule fluorescent probes for chemoselective bioimaging.

  2012cited by this paper
• High-Throughput Fluorescence Polarization Assay for Chemical Library Screening against Anti-Apoptotic Bcl-2 Family Member Bfl-1

  2012cited by this paper
• Naphthalimide-tagged ruthenium-arene anticancer complexes: combining coordination with intercalation

  2012cited by this paper
• Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency.

  2012cited by this paper
• Fluorescent small molecule probe to modulate and explore α2β1 integrin function.

  2011cited by this paper
• The BCL-2 family reunion.

  2010cited by this paper
• Aberrant Reactive Oxygen and Nitrogen Species Generation in Rheumatoid Arthritis (RA): Causes and Consequences for Immune Function, Cell Survival, and Therapeutic Intervention

  2010cited by this paper
• The landscape of somatic copy-number alteration across human cancers

  2010cited by this paper
• Bcl‐XL and MCL‐1 constitute pertinent targets in ovarian carcinoma and their concomitant inhibition is sufficient to induce apoptosis

  2009cited by this paper
• Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.

  2008cited by this paper
• The BCL-2 protein family: opposing activities that mediate cell death

  2008cited by this paper
• A versatile amino acid analogue of the solvatochromic fluorophore 4-N,N-dimethylamino-1,8-naphthalimide: a powerful tool for the study of dynamic protein interactions.

  2008cited by this paper
• Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

  2007cited by this paper
• Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.

  2007cited by this paper
• The Bcl-2 apoptotic switch in cancer development and therapy

  2007cited by this paper
• Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells

  2005cited by this paper
• The antiapoptotic member of the Bcl-2 family Mcl-1 is a CTL target in cancer patients

  2005cited by this paper
• Solvent-sensitive dyes to report protein conformational changes in living cells.

  2003cited by this paper
• Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.

  2002cited by this paper
• Apoptosis A Link between Cancer Genetics and Chemotherapy

  2002cited by this paper
• Probing Protein Electrostatics with a Synthetic Fluorescent Amino Acid

  2002cited by this paper
• Immunohistochemical Analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 Expression in Pancreatic Cancers

  1999cited by this paper
• Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.

  1996cited by this paper

• Novel active site -targeted fluorescent probes for real-time monitoring of CDK4/6 in tumor cells and tissues.

  2026cites this paper
• Achieving dual-target fluorescent probes for tracing and inhibiting BRD4/PLK1 in tumor cells and tissues synchronously.

  2025cites this paper
• Fmoc-FF hydrogels and nanogels for improved and selective delivery of dexamethasone in leukemic cells and diagnostic applications

  2024cites this paper
• Establishment of environment-sensitive probes targeting BRD3/BRD4 for imaging and therapy of tumor.

  2023cites this paper
• Bio-orthogonally Activatable Fluorescent Probe for Specific Imaging of Myeloid Cell Leukemia 1 Protein.

  2023cites this paper
• Effect of metal coordination in modulating the binding interaction of an arylimidazole-derived organic chromophore with lipase

  2023cites this paper
• Discovery of environment-sensitive fluorescent probes for detecting and inhibiting metallo-β-lactamase.

  2022cites this paper
• Discovery of EGFR-Targeted Environment-Sensitive fluorescent probes for cell imaging and efficient tumor detection.

  2022cites this paper
• Real-Time Fluorescence Imaging of the Abscisic Acid Receptor Allows Nondestructive Visualization of Plant Stress.

  2022cites this paper
• Real-time Visualization of Efficient Nitroxyl (HNO) Releasing using Fluorescence Technique

  2022cites this paper
• Polarity-based fluorescence probes: properties and applications.

  2021cites this paper
• Synthesis and evaluation of a UMI-77-based fluorescent probe for selective detecting Mcl-1 protein and imaging in living cancer cells.

  2020cites this paper
• A “Three‐in‐One” Multifunctional Probe for Bcl‐2/Mcl‐1 Profiling and Visualizing in Situ

  2020cites this paper
• Discovery of Turn-On Fluorescent Probes for Detecting Bcl-2 Protein.

  2019cites this paper
• A fluorescence sensing platform of theophylline based on the interaction of RNA aptamer with graphene oxide

  2019cites this paper
• Discovery of Environment-Sensitive Fluorescent Agonists for α1-Adrenergic Receptors.

  2019cites this paper
• Fluorescent “keep-on” type pharmacophore obtained from dynamic combinatorial library of Schiff bases

  2018influential citation