The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Oncogene

• Publication date

  1999-11-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1203072PMID 10597274
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans.

  1998cited by this paper
• POU Transcription Factors Brn-3a and Brn-3b Interact with the Estrogen Receptor and Differentially Regulate Transcriptional Activity via an Estrogen Response Element

  1998cited by this paper
• The HPV-activating cellular transcription factor Brn-3a is overexpressed in CIN3 cervical lesions.

  1998cited by this paper
• Kennewick Man: More Bones to Pick

  1998cited by this paper
• Bcl-2 Transcription from the Proximal P2 Promoter Is Activated in Neuronal Cells by the Brn-3a POU Family Transcription Factor*

  1998cited by this paper
• POU domain family values: flexibility, partnerships, and developmental codes.

  1997influential reference
• Coordinate Induction of the Three Neurofilament Genes by the Brn-3a Transcription Factor*

  1997cited by this paper
• Regulation of neuroblastoma growth and differentiation by the POU family transcription factors Brn-3a and Brn-3b (Review).

  1997cited by this paper
• The BRCA1 and BRCA2 breast cancer genes.

  1997cited by this paper
• The functionally antagonistic POU family transcription factors Brr‐3a and Brn‐3b show opposite changes in expression during the growth arrest and differentiation of human neuroblastoma cells

  1996cited by this paper
• Growth retardation and tumour inhibition by BRCA1

  1996cited by this paper
• Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors.

  1996cited by this paper
• Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.

  1995cited by this paper
• The Neuronal Nicotinic Acetylcholine Receptor α2 Subunit Gene Promoter Is Activated by the Brn-3b POU Family Transcription Factor and Not by Brn-3a or Brn-3c (*)

  1995cited by this paper
• Association between X-linked mixed deafness and mutations in the POU domain gene POU3F4

  1995cited by this paper
• Hormone-dependent regulation of BRCA1 in human breast cancer cells.

  1995cited by this paper
• Activation of the α-Internexin Promoter by the Brn-3a Transcription Factor Is Dependent on the N-terminal Region of the Protein (*)

  1995cited by this paper
• The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

  1995cited by this paper
• Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

  1995influential reference
• Isolation of the mouse homologue of BRCA1 and genetic mapping to mouse chromosome 11.

  1995cited by this paper
• The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain

  1994influential reference
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

  1994cited by this paper
• BRCA1 mutations in primary breast and ovarian carcinomas.

  1994influential reference
• Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid.

  1994cited by this paper
• Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a.

  1993cited by this paper
• Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs.

  1993cited by this paper
• Immediate and transient stimulation of protein tyrosine phosphorylation by estradiol in MCF-7 cells.

  1993cited by this paper
• Differential heat shock protein overexpression and its clinical relevance in systemic lupus erythematosus.

  1993cited by this paper
• POU domain transcription factors.

  1993cited by this paper
• A novel Brn3-like POU transcription factor expressed in subsets of rat sensory and spinal cord neurons.

  1993cited by this paper
• A procedure to standardize CAT reporter gene assay

  1992cited by this paper
• A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells.

  1992cited by this paper
• Expression of a large family of POU-domain regulatory genes in mammalian brain development

  1989influential reference
• Expression of a large family of POU-domain regulatory genes in mammalian brain development

  1989cited by this paper
• DNA cloning : a practical approach

  1985cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

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  2022cites this paper
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  2021cites this paper
• Linking metabolic dysfunction with cardiovascular diseases: Brn-3b/POU4F2 transcription factor in cardiometabolic tissues in health and disease

  2021cites this paper
• Expression and function of the POU4F2/Brn3b transcription factor in the heart during development and in responses to stress

  2019cites this paper
• The POU4F2/Brn-3b transcription factor is required for the hypertrophic response to angiotensin II in the heart

  2019cites this paper
• SpliceRCA: in Situ Single-Cell Analysis of mRNA Splicing Variants

  2018cites this paper
• POU4F2/Brn-3b transcription factor is associated with survival and drug resistance in human ovarian cancer cells

  2018influential citation
• Brn-3a and Brn-3b are differentially expressed in recurrent respiratory papillomatosis associated to HPV-6 and HPV-11 infection

  2018cites this paper
• A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome

  2017cites this paper
• Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study

  2016cites this paper
• Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes.

  2016cites this paper
• POU transcription factors in melanocytes and melanoma.

  2014cites this paper
• Quantitative imaging of single mRNA splice variants in living cells.

  2014cites this paper
• Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults

  2014cites this paper
• The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival

  2013influential citation
• Hsp-27 induction requires POU4F2/Brn-3b TF in doxorubicin-treated breast cancer cells, whereas phosphorylation alters its cellular localisation following drug treatment

  2011influential citation
• Comprehensive Genome Methylation Analysis in Bladder Cancer: Identification and Validation of Novel Methylated Genes and Application of These as Urinary Tumor Markers

  2011cites this paper
• Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway

  2011cites this paper
• Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer

  2010cites this paper
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  2010cites this paper
• Identification and Characterization of Novel Kinases that Regulate BRCA1 Expression and Function

  2010cites this paper
• Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis.

  2010cites this paper
• Verification of genes differentially expressed in neuroblastoma tumours: a study of potential tumour suppressor genes

  2009cites this paper
• Transcription factors: their potential as targets for an individualized therapeutic approach to cancer

  2009cites this paper
• Use of novel assays to measure in vivo base excision DNA repair

  2009cites this paper
• Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells

  2008cites this paper
• Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression

  2008cites this paper
• Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication

  2008cites this paper
• Nuclear receptor coregulators and human disease.

  2008cites this paper
• Brn3 transcription factors control terminal osteoclastogenesis

  2007cites this paper
• Heat Shock Protein-27 (Hsp-27) in Breast Cancers: Regulation of Expression and Function

  2007cites this paper
• Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization.

  2007cites this paper
• A Single Decoy Oligodeoxynucleotides Targeting Multiple Oncoproteins Produces Strong Anticancer Effects

  2006influential citation
• Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

  2006cites this paper
• Brn-3a neuronal transcription factor functional expression in human prostate cancer

  2006cites this paper
• Targeting Brn-3b in breast cancer therapy

  2006influential citation
• The Brn‐3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells

  2006cites this paper
• Embryonic transcription factors in human breast cancer

  2006influential citation
• Brn-3 b enhances the pro-apoptotic effects of p 53 but not its induction of cell cycle arrest by cooperating in transactivation of bax expression

  2006influential citation
• Identification of an N-terminal transcriptional activation domain within Brn3b/POU4f2.

  2005cites this paper
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  2005cites this paper
• Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.

  2005cites this paper
• The Brn-3b Transcription Factor Regulates the Growth, Behavior, and Invasiveness of Human Neuroblastoma Cells in Vitro and in Vivo*

  2004cites this paper
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  2004cites this paper
• Coupling the Transcriptional Regulatory Action of Brn-3b to the Cell Cycle Clock

  2004cites this paper
• Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina

  2004cites this paper
• The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo.

  2004cites this paper
• The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1

  2004cites this paper
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  2004cites this paper
• Role of the Brn-3a and Brn-3b POU family transcription factors in cancer

  2004cites this paper
• Sensory neurons from mice lacking the Brn-3b POU family transcription factor are resistant to death-inducing stimuli both in vitro and in vivo.

  2003cites this paper
• Expression of Developmentally Regulated Transcription Factors in Merkel Cell Carcinoma

  2003cites this paper
• The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells.

  2003cites this paper
• Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor γ in the MCF-7 breast cancer cell line

  2003cites this paper
• BRCA1 gene in breast cancer

  2003cites this paper
• Emerging roles of BRCA1 alternative splicing

  2003cites this paper
• Role of Homeobox Genes in Normal Mammary Gland Development and Breast Tumorigenesis

  2003cites this paper
• BRCA1 in hormone-responsive cancers.

  2003cites this paper
• BRCA1 methylation: a significant role in tumour development?

  2002cites this paper
• Functional interaction between Brn-3a and Src-1 co-activates Brn-3a-mediated transactivation.

  2002cites this paper
• Structural Determinants of BRCA1 Translational Regulation*

  2002cites this paper
• Identification of genes induced by BRCA1 in breast cancer cells.

  2002cites this paper
• Genes, Chromatin, and Breast Cancer: An Epigenetic Tale

  2001cites this paper
• The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells

  2001cites this paper
• Expression profiles of BRCA1 splice variants in asynchronous and in G1/S synchronized tumor cell lines.

  2001cites this paper
• BRCA1 and BRCA2 and the genetics of breast and ovarian cancer.

  2001cites this paper
• Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach.

  2001cites this paper
• The closely related POU family transcription factors Brn-3a and Brn-3b are expressed in distinct cell types in the testis.

  2001cites this paper
• The BRN-3A Transcription Factor Protects Sensory but Not Sympathetic Neurons from Programmed Cell Death/Apoptosis*

  2001cites this paper
• Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes.

  2001cites this paper
• Identification of a novel transcriptional repressor element located in the first intron of the human BRCA1 gene

  2001cites this paper
• Hereditary common cancers: molecular and clinical genetics.

  2000cites this paper
• All Brn3 genes can promote retinal ganglion cell differentiation in the chick.

  2000cites this paper
• BRCA1: what do we know? What do we think we know? What do we really need to know?

  2000cites this paper