Characterization of the mitochondrial inner membrane protein translocator Tim17 from Trypanosoma brucei.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Molecular and biochemical parasitology (Print)

• Publication date

  2008-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.molbiopara.2008.01.003PMID 18325611PMCID PMC2954128
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Trypanosoma brucei: differential requirement of membrane potential for import of proteins into mitochondria in two developmental stages.

  2008cited by this paper
• Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space.

  2007cited by this paper
• Motor-free mitochondrial presequence translocase drives membrane integration of preproteins

  2007cited by this paper
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• Trypanosome alternative oxidase: from molecule to function.

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• In situ background estimation in quantitative fluorescence imaging.

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• ATP Synthase Is Responsible for Maintaining Mitochondrial Membrane Potential in Bloodstream Form Trypanosoma brucei

  2006cited by this paper
• Tim17p Regulates the Twin Pore Structure and Voltage Gating of the Mitochondrial Protein Import Complex TIM23*

  2006cited by this paper
• Gene delivery of Tim44 reduces mitochondrial superoxide production and ameliorates neointimal proliferation of injured carotid artery in diabetic rats.

  2005cited by this paper
• Substrate Specificity, Localization, and Essential Role of the Glutathione Peroxidase-type Tryparedoxin Peroxidases in Trypanosoma brucei*

  2005cited by this paper
• Gene delivery of Tim44 reduces mitochondrial superoxide production and ameliorates neointimal proliferation of injured carotid artery in diabetic rats

  2005cited by this paper
• Biogenesis of β-barrel membrane proteins of mitochondria

  2005cited by this paper
• Energy metabolism and its compartmentation in Trypanosoma brucei.

  2005cited by this paper
• Biogenesis of beta-barrel membrane proteins of mitochondria.

  2005cited by this paper
• Protein import into mitochondria: origins and functions today (Review)

  2005cited by this paper
• How does the TOM complex mediate insertion of precursor proteins into the mitochondrial outer membrane?

  2005cited by this paper
• Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.

  2005cited by this paper
• Conserved N-terminal Negative Charges in the Tim17 Subunit of the TIM23 Translocase Play a Critical Role in the Import of Preproteins into Mitochondria*

  2005cited by this paper
• Unexplained complexity of the mitochondrial genome and transcriptome in kinetoplastid flagellates

  2005cited by this paper
• The C-terminal Region of TIM17 Links the Outer and Inner Mitochondrial Membranes in Arabidopsis and Is Essential for Protein Import*

  2005cited by this paper
• RNA interference for analysis of gene function in trypanosomatids.

  2004cited by this paper
• Control of gene expression and genetic manipulation in the Trypanosomatidae.

  2003cited by this paper
• Trypanosoma brucei Cytochromec 1 Is Imported into Mitochondria Along an Unusual Pathway*

  2003cited by this paper
• Identification, Expression, and Import of Components 17 and 23 of the Inner Mitochondrial Membrane Translocase from Arabidopsis1,212

  2003cited by this paper
• Functional cooperation and separation of translocators in protein import into mitochondria, the double-membrane bounded organelles

  2003cited by this paper
• The delivery of ADP/ATP carrier protein to mitochondria probed by fusions with green fluorescent protein and beta-galactosidase.

  2003cited by this paper
• Tim50, a novel component of the TIM23 preprotein translocase of mitochondria

  2003cited by this paper
• Import and assembly of Neurospora crassa Tom40 into mitochondria of Trypanosoma brucei in vivo

  2003cited by this paper
• Trypanosome Alternative Oxidase is Regulated Post-transcriptionally at the Level of RNA Stability

  2002cited by this paper
• Mitochondrial Import of the ADP/ATP Carrier: the Essential TIM Complex of the Intermembrane Space Is Required for Precursor Release from the TOM Complex

  2002cited by this paper
• Mitochondrial processing peptidases.

  2002cited by this paper
• A putative novel nuclear-encoded subunit of the cytochrome c oxidase complex in trypanosomatids.

  2002cited by this paper
• Targeting of a tetracycline-inducible expression system to the transcriptionally silent minichromosomes of Trypanosoma brucei.

  2002cited by this paper
• Versatility of the mitochondrial protein import machinery

  2001cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Four Related Proteins of the Trypanosoma brucei RNA Editing Complex

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• Cloning and characterization of a novel serine/threonine protein phosphatase type 5 from Trypanosoma brucei.

  2001cited by this paper
• An RNA Ligase Essential for RNA Editing and Survival of the Bloodstream Form of Trypanosoma brucei

  2001cited by this paper
• Modular Structure of the TIM23 Preprotein Translocase of Mitochondria*

  2001cited by this paper
• Unique aspects of mitochondrial biogenesis in trypanosomatids.

  2001cited by this paper
• A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23

  2001cited by this paper
• Roles of triosephosphate isomerase and aerobic metabolism in Trypanosoma brucei.

  2001cited by this paper
• Import of a constitutively expressed protein into mitochondria from procyclic and bloodstream forms of Trypanosoma brucei.

  2000cited by this paper
• Protein translocation pathways of the mitochondrion

  2000cited by this paper
• Genetic and structural characterization of the human mitochondrial inner membrane translocase.

  1999influential reference
• Biochemical and molecular properties of the Trypanosoma brucei alternative oxidase.

  1998cited by this paper
• Vectors for inducible expression of toxic gene products in bloodstream and procyclic Trypanosoma brucei.

  1997cited by this paper
• In Vitro Import of the Rieske Iron-Sulfur Protein by Trypanosome Mitochondria*

  1996cited by this paper
• The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17.

  1996influential reference
• Using CLUSTAL for multiple sequence alignments.

  1996cited by this paper
• Developmental regulation of mitochondrial biogenesis inTrypanosoma brucei

  1994cited by this paper
• Identification of the essential yeast protein MIM17, an integral mitochondrial inner membrane protein involved in protein import

  1994cited by this paper
• Developmental regulation of Trypanosoma brucei cytochrome c reductase during bloodstream to procyclic differentiation.

  1994cited by this paper
• A mitochondrial heat shock protein from Crithidia fasciculata.

  1993cited by this paper
• Characterization of a Trypanosoma brucei nuclear gene encoding a protein homologous to a subunit of bovine NADH:ubiquinone oxidoreductase (complex I).

  1993cited by this paper
• Tmbase-A database of membrane spanning protein segments

  1993cited by this paper
• In vitro cultivation of Trypanosoma congolense bloodstream forms in the absence of feeder cell layers

  1991cited by this paper
• Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins

  1990cited by this paper
• Production and characterization of monoclonal antibodies to the mammalian sperm cytoskeleton

  1990cited by this paper
• Definition of individual components within the cytoskeleton of Trypanosoma brucei by a library of monoclonal antibodies.

  1989cited by this paper
• Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

  1979cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• Cleavage of structural proteins during

  1970cited by this paper

• TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome

  2025cites this paper
• Intermembrane space‐localized TbTim15 is an essential subunit of the single mitochondrial inner membrane protein translocase of trypanosomes

  2024cites this paper
• Intermembrane space-localized twin Cx9C motif-containing TbTim15 is an essential subunit of the single mitochondrial inner membrane protein translocase of trypanosomes

  2024cites this paper
• Distinct structural motifs are necessary for targeting and import of Tim17 in Trypanosoma brucei mitochondrion

  2024cites this paper
• Distinct structural motifs are necessary for targeting and import of Tim17 in Trypanosoma brucei mitochondrion

  2023influential citation
• Unique interactions and functions of the mitochondrial small Tims in Trypanosoma brucei

  2023cites this paper
• Evolution and diversification of mitochondrial protein import systems.

  2022cites this paper
• Is the mitochondrion a promising drug target in trypanosomatids?

  2022cites this paper
• A novel connection between Trypanosoma brucei mitochondrial proteins TbTim17 and TbTRAP1 is discovered using Biotinylation Identification (BioID)

  2022cites this paper
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  2021influential citation
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
• Cardiolipin depletion‐induced changes in the Trypanosoma brucei proteome

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
• A Single Tim Translocase in the Mitosomes of Giardia intestinalis Illustrates Convergence of Protein Import Machines in Anaerobic Eukaryotes

  2018cites this paper
• Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei

  2018cites this paper
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  2017cites this paper
• Biogenesis of the mitochondrial DNA inheritance machinery in the mitochondrial outer membrane of Trypanosoma brucei

  2017cites this paper
• Origin and Evolutionary Alteration of the Mitochondrial Import System in Eukaryotic Lineages

  2017cites this paper
• Report nslocase of Trypanosomatids Has a Bacterial Origin

  2017cites this paper
• Declaration of the supervisor / Prohlášení školitele

  2017cites this paper
• Biogenesis of a mitochondrial DNA inheritance machinery in the mitochondrial outer membrane

  2017cites this paper
• The divergent N-terminal domain of Tim17 is critical for its assembly in the TIM complex in Trypanosoma brucei.

  2017cites this paper
• Biogenesis of mitochondria in parasitic protist Trypanosoma brucei

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
• Functional Complementation Analyses Reveal that the Single PRAT Family Protein of Trypanosoma brucei Is a Divergent Homolog of Tim17 in Saccharomyces cerevisiae

  2015cites this paper
• Tim62, a Novel Mitochondrial Protein in Trypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex*

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  2015cites this paper
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• Wherever I may roam: protein and membrane trafficking in P. falciparum-infected red blood cells.

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• In vivo study in Trypanosoma brucei links mitochondrial transfer RNA import to mitochondrial protein import

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• Role of Tob55 on mitochondrial protein biogenesis in Trypanosoma brucei.

  2010cites this paper
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• Downregulation of Mitochondrial Porin Inhibits Cell Growth and Alters Respiratory Phenotype in Trypanosoma brucei

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• Title Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei Permalink

  2008cites this paper