Deletion of Ribosomal S 6 Kinases Does Not Attenuate Pathological , Physiological , or Insulin-Like Growth Factor 1 Receptor – Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies.

  2004cited by this paper
• Inhibition of mTOR Signaling With Rapamycin Regresses Established Cardiac Hypertrophy Induced by Pressure Overload

  2004cited by this paper
• The Insulin-like Growth Factor 1 Receptor Induces Physiological Heart Growth via the Phosphoinositide 3-Kinase(p110α) Pathway*

  2004cited by this paper
• S6K1−/−/S6K2−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

  2004cited by this paper
• mTOR-mediated regulation of translation factors by amino acids.

  2004cited by this paper
• Rapamycin Attenuates Load-Induced Cardiac Hypertrophy in Mice

  2003cited by this paper
• Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy

  2003cited by this paper
• Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E.

  2002cited by this paper
• Transduction of Growth or Mitogenic Signals into Translational Activation of TOP mRNAs Is Fully Reliant on the Phosphatidylinositol 3-Kinase-Mediated Pathway but Requires neither S6K1 nor rpS6 Phosphorylation

  2002cited by this paper
• Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling.

  2002cited by this paper
• dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1

  2002cited by this paper
• Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice

  2002cited by this paper
• Amino Acid-Induced Translation of TOP mRNAs Is Fully Dependent on Phosphatidylinositol 3-Kinase-Mediated Signaling, Is Partially Inhibited by Rapamycin, and Is Independent of S6K1 and rpS6 Phosphorylation

  2001cited by this paper
• Ribosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation*

  2001cited by this paper
• Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat.

  2001cited by this paper
• Developing a Strategy to Define the Effects of Insulin-Like Growth Factor-1 on Gene Expression Profile in Cardiomyocytes

  2001cited by this paper
• Activation of cardiac renin-angiotensin system in unstable angina.

  2001cited by this paper
• Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase Pathway*

  2001cited by this paper
• Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes

  2001cited by this paper
• Increased Cardiac Sympathetic Activity and Insulin-Like Growth Factor-I Formation Are Associated With Physiological Hypertrophy in Athletes

  2001cited by this paper
• Time course evaluation of protein synthesis and glucose uptake after acute resistance exercise in rats.

  2000cited by this paper
• 23 S6 Phosphorylation and Signal Transduction

  2000cited by this paper
• Regulation of cellular growth by the Drosophila target of rapamycin dTOR.

  2000cited by this paper
• Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps.

  2000cited by this paper
• Specificity and mechanism of action of some commonly used protein kinase inhibitors.

  2000cited by this paper
• The conserved phosphoinositide 3‐kinase pathway determines heart size in mice

  2000cited by this paper
• 4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle.

  2000cited by this paper
• Characterization of S6K2, a novel kinase homologous to S6K1

  1999cited by this paper
• Regulation of growth in the adult cardiomyocytes

  1999cited by this paper
• Drosophila S6 kinase: a regulator of cell size.

  1999cited by this paper
• Ribosomal S6 kinase signaling and the control of translation.

  1999cited by this paper
• Insulin-like growth factor I as a cardiac hormone: physiological and pathophysiological implications in heart disease.

  1999cited by this paper
• Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase

  1998cited by this paper
• Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice.

  1998cited by this paper
• Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.

  1998cited by this paper
• Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein.

  1998cited by this paper
• Rapamycin inhibits alpha 1-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinase.

  1997cited by this paper
• Transgenic Gαq overexpression induces cardiac contractile failure in mice

  1997cited by this paper
• TOR signalling and control of cell growth.

  1997cited by this paper
• A signaling pathway to translational control.

  1996cited by this paper
• Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.

  1996cited by this paper
• Angiotensin receptor 1 blockade does not prevent physiological cardiac hypertrophy in the adult rat.

  1996cited by this paper
• Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy.

  1995cited by this paper
• Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure.

  1995cited by this paper
• The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling.

  1995cited by this paper
• Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases.

  1992cited by this paper
• Isolation and characterization of the mouse cardiac myosin heavy chain genes.

  1991cited by this paper
• Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study.

  1990cited by this paper
• Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

  1988cited by this paper
• The cardiac hypertrophic responses to pathologic and physiologic loads.

  1987cited by this paper

• The mTOR signaling pathway in cardiac aging

  2023cites this paper
• MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation

  2021cites this paper
• Ribosomal protein S6 kinase beta-1 gene variants cause hypertrophic cardiomyopathy

  2021cites this paper
• Exploration of Multiple Signaling Pathways Through Which Sodium Tanshinone IIA Sulfonate Attenuates Pathologic Remodeling Experimental Infarction

  2019cites this paper
• Mammalian target of rapamycin signaling in cardiac physiology and disease.

  2014cites this paper
• Main Studies That Investigated the Role of mTOR Kinase in the Regulation of Cardiac Physiology and Response to Stress In Vivo Cardiac Condition Study Type of mTOR Modulation and Animal Model Effect on the Heart Development / physiological conditions

  2014cites this paper
• p70 Ribosomal protein S6 kinase (Rps6kb1): an update

  2014cites this paper
• Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks.

  2012cites this paper
• Drosophila models of cardiac disease.

  2011cites this paper
• Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies.

  2010cites this paper
• Antisense Inhibition of S6 Kinase 1 Produces Improved Glucose Tolerance and Is Well Tolerated for 4 Weeks of Treatment in Rats

  2010cites this paper
• Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction.

  2009cites this paper
• Selective activation of PI3Kα/Akt/GSK‐3β signalling and cardiac compensatory hypertrophy during recovery from heart failure

  2009cites this paper
• Differential expression of 14-3-3ε during physiological, pathological cardiac hypertrophy and chronic heart failure in mice

  2009cites this paper
• Physiological myocardial hypertrophy: how and why?

  2008cites this paper
• Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway.

  2006cites this paper
• The mTOR pathway in the control of protein synthesis.

  2006cites this paper
• Inhibition of mTOR Signaling With Rapamycin Regresses Established Cardiac Hypertrophy Induced by Pressure Overload

  2004cites this paper