Targeted inhibition of IL‐10‐secreting CD25− Treg via p38 MAPK suppression in cancer immunotherapy

No abstract is available for this paper.

• Publication year

  2010

• Venue

  European Journal of Immunology

• Publication date

  2010-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/eji.200939513PMID 20127675
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007cited by this paper
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  2006cited by this paper
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• Inducing and expanding regulatory T cell populations by foreign antigen

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  2005cited by this paper
• Induction of T helper type 1–like regulatory cells that express Foxp3 and protect against airway hyper-reactivity

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  2003cited by this paper
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  2001cited by this paper
• TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.

  1996cited by this paper
• TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

  1996cited by this paper
• T cell receptor antagonist peptides induce positive selection.

  1994cited by this paper
• Self-reactive T cells can escape clonal deletion in T-cell receptor V beta 8.1 transgenic mice.

  1990cited by this paper
• PROTOCOLS FOR SCREENING CHEMICAL AGENTS AND NATURAL PRODUCTS AGAINST ANIMAL TUMORS AND OTHER BIOLOGICAL SYSTEMS

  1972cited by this paper
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  year unknowncited by this paper

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