The anti-catabolic role of bovine lactoferricin in cartilage

Abstract Bovine lactoferricin (LfcinB) is a multifunctional peptide derived from bovine lactoferrin that demonstrates antibacterial, antifungal, antiviral, antitumor, and immunomodulatory activities. Recently, studies have focused on the anti-catabolic and anti-inflammatory potential of LfcinB. LfcinB is able to modulate the effects cytokines such as IL-1 and fibroblast growth factor 2 as well as promote specific cartilage anabolic factors. These properties are particularly important in maintaining cartilage homeostasis and preventing a catabolic state, which leads to clinical pathology. This review focuses on the recent literature elucidating the role of LfcinB in preventing cartilage degradation.

• Publication year

  2013

• Venue

  Biomolecular Concepts

• Publication date

  2013-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1515/bmc-2013-0013PMID 25436593
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bovine lactoferricin induces TIMP-3 via the ERK1/2-Sp1 axis in human articular chondrocytes.

  2013cited by this paper
• Bovine lactoferricin is anti‐inflammatory and anti‐catabolic in human articular cartilage and synovium

  2013cited by this paper
• Lactoferricin mediates anti‐inflammatory and anti‐catabolic effects via inhibition of IL‐1 and LPS activity in the intervertebral disc

  2013cited by this paper
• Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells.

  2013cited by this paper
• Lactoferricin mediates anabolic and anti‐catabolic effects in the intervertebral disc

  2012cited by this paper
• Osteoarthritis year 2010 in review: pathomechanisms.

  2011cited by this paper
• New hope for the treatment of osteoarthritis through selective inhibition of MMP-13.

  2011cited by this paper
• Hyaluronan reduces inflammation in experimental arthritis by modulating TLR-2 and TLR-4 cartilage expression.

  2011cited by this paper
• Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation.

  2010cited by this paper
• STRUCTURE-BIOLOGICAL ACTIVITY RELATIONSHIPS OF 11-RESIDUE HIGHLY BASIC PEPTIDE SEGMENT OF BOVINE LACTOFERRIN

  2009cited by this paper
• Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration

  2009cited by this paper
• Progress towards the identification of new aggrecanase inhibitors.

  2009cited by this paper
• Basic fibroblast growth factor accelerates matrix degradation via a neuro‐endocrine pathway in human adult articular chondrocytes

  2008cited by this paper
• Basic Fibroblast Growth Factor Activates the MAPK and NFκB Pathways That Converge on Elk-1 to Control Production of Matrix Metalloproteinase-13 by Human Adult Articular Chondrocytes*

  2007cited by this paper
• Mammary gland expression of antibacterial peptide genes to inhibit bacterial pathogens causing mastitis.

  2007cited by this paper
• Bovine lactoferricin causes apoptosis in Jurkat T-leukemia cells by sequential permeabilization of the cell membrane and targeting of mitochondria.

  2007cited by this paper
• Basic Fibroblast Growth Factor Stimulates Matrix Metalloproteinase-13 via the Molecular Cross-talk between the Mitogen-activated Protein Kinases and Protein Kinase Cδ Pathways in Human Adult Articular Chondrocytes*

  2007cited by this paper
• The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes.

  2006cited by this paper
• Comparative Effects of Bone Morphogenetic Proteins and Sox9 Overexpression on Extracellular Matrix Metabolism of Bovine Nucleus Pulposus Cells

  2006cited by this paper
• An altruistic approach to clinical trials: the National Clinical Trials Consortium (NCTC).

  2006cited by this paper
• Osteogenic Protein-1 Injection Into a Degenerated Disc Induces the Restoration of Disc Height and Structural Changes in the Rabbit Anular Puncture Model

  2006cited by this paper
• Bovine lactoferricin inhibits basic fibroblast growth factor- and vascular endothelial growth factor165-induced angiogenesis by competing for heparin-like binding sites on endothelial cells.

  2006cited by this paper
• Lactoferrin

  2005cited by this paper
• Expression and regulation of Toll-like receptor 2 by IL-1beta and fibronectin fragments in human articular chondrocytes.

  2005cited by this paper
• TGF‐β‐induced expression of tissue inhibitor of metalloproteinases‐3 gene in chondrocytes is mediated by extracellular signal‐regulated kinase pathway and Sp1 transcription factor

  2005cited by this paper
• Lactoferricin

  2005cited by this paper
• The impact of osteoarthritis: implications for research.

  2004cited by this paper
• Oral administration of lactoferrin inhibits inflammation and nociception in rat adjuvant-induced arthritis.

  2004cited by this paper
• Degeneration of intervertebral discs: current understanding of cellular and molecular events, and implications for novel therapies

  2001cited by this paper
• TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)*

  2001cited by this paper
• The role of the chondrocyte in osteoarthritis.

  2000cited by this paper
• The effects of local administration of lactoferrin on inflammation in murine autoimmune and infectious arthritis.

  2000cited by this paper
• SOX9 Enhances Aggrecan Gene Promoter/Enhancer Activity and Is Up-regulated by Retinoic Acid in a Cartilage-derived Cell Line, TC6*

  2000cited by this paper
• Epidemiological features of chronic low-back pain.

  1999cited by this paper
• Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin.

  1998cited by this paper
• Direct detection and quantitative determination of bovine lactoferricin and lactoferrin fragments in human gastric contents by affinity mass spectrometry.

  1998influential reference
• Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes.

  1996cited by this paper
• The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family.

  1996cited by this paper
• Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation

  1996cited by this paper
• Aging and degeneration of the human intervertebral disc.

  1995cited by this paper
• Structure of the human TIMP-3 gene and its cell cycle-regulated promoter.

  1995influential reference
• Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro.

  1992cited by this paper
• Lactoferrin Content of Peripheral Blood Cells

  1978cited by this paper
• The proteins in whey.

  1940cited by this paper
• STUDIES ON THE THEORY OF DIABETES V. A STUDY OF NARCOTIC DRUGS IN PHLORHIZIN DIABETES

  1915cited by this paper

• Oral administration of LfcinB alleviates DSS-induced colitis by improving the intestinal barrier and microbiota.

  2024cites this paper
• Bovine lactoferrin inhibits Plasmodium berghei growth by binding to heme

  2024influential citation
• JUVENIL, A NATURAL IMMUNE BOOSTER AFFECTING BIOLOGICAL RESPONSES THROUGH MODULATION OF GUT MICROBIOTA COMPOSITION

  2023cites this paper
• Functional attributes of bioactive peptides of bovine milk origin and application of in silico approaches for peptide prediction and functional annotations

  2023cites this paper
• Colostrum Proteins in Protection against Therapy-Induced Injuries in Cancer Chemo- and Radiotherapy: A Comprehensive Review

  2023cites this paper
• Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications

  2022cites this paper
• Design of bovine lactoferricin-derived peptide and its expression and activity in Pichia pastoris.

  2020cites this paper