Protein kinase C α inhibition prevents peritoneal damage in a mouse model of chronic peritoneal exposure to high-glucose dialysate.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Kidney International

• Publication date

  2016-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.kint.2016.01.025PMID 27142955
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of NADPH Oxidase 5 by Protein Kinase C Isoforms

  2014cited by this paper
• The endothelial-mesenchymal transition (EndMT) and tissue regeneration.

  2014cited by this paper
• Associations between the Duration of Dialysis, Endotoxemia, Monocyte Chemoattractant Protein-1, and the Effects of a Short-Dwell Exchange in Patients Requiring Continuous Ambulatory Peritoneal Dialysis

  2014cited by this paper
• Protein kinase C in cellular transformation: a valid target for therapy?

  2014cited by this paper
• Involvement of inflammation-related miR-155 and miR-146a in diabetic nephropathy: implications for glomerular endothelial injury

  2014cited by this paper
• Lineage tracing reveals distinctive fates for mesothelial cells and submesothelial fibroblasts during peritoneal injury.

  2014cited by this paper
• IL-17A is a novel player in dialysis-induced peritoneal damage.

  2014cited by this paper
• The stress-related hormone norepinephrine induced upregulation of Nix, contributing to ECM protein expression

  2014cited by this paper
• Fos-icking for control of angiogenesis: increasing the longevity of peritoneal dialysis.

  2013cited by this paper
• Cost of peritoneal dialysis and haemodialysis across the world.

  2013cited by this paper
• Acortatarin A inhibits high glucose‐induced extracellular matrix production in mesangial cells

  2013cited by this paper
• Hu-Lu-Ba-Wan Attenuates Diabetic Nephropathy in Type 2 Diabetic Rats through PKC-α/NADPH Oxidase Signaling Pathway

  2013cited by this paper
• Protein kinase Cα inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer.

  2013cited by this paper
• Dual Inhibition of Classical Protein Kinase C-α and Protein Kinase C-β Isoforms Protects Against Experimental Murine Diabetic Nephropathy

  2013cited by this paper
• Functional Relevance of the Switch of VEGF Receptors/Co-Receptors during Peritoneal Dialysis-Induced Mesothelial to Mesenchymal Transition

  2013cited by this paper
• The Kinase PKCα Selectively Upregulates Interleukin-17A during Th17 Cell Immune Responses

  2013cited by this paper
• Transforming growth factor β-induced peritoneal fibrosis is mouse strain dependent.

  2013cited by this paper
• The monocyte chemoattractant protein-1 (MCP-1)/CCR2 system is involved in peritoneal dialysis-related epithelial–mesenchymal transition of peritoneal mesothelial cells

  2012cited by this paper
• C57BL/6 and 129/Sv mice: genetic difference to renal ischemia-reperfusion.

  2012cited by this paper
• Global trends in rates of peritoneal dialysis.

  2012cited by this paper
• Protein kinase C, an elusive therapeutic target?

  2012cited by this paper
• Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC-MAPK signaling pathway.

  2012cited by this paper
• Effect of peritoneal dialysis on expression of vascular endothelial growth factor, basic fibroblast growth factor and endostatin of the peritoneum in peritoneal dialysis patients

  2011cited by this paper
• Regulation of endothelial cell plasticity by TGF-β

  2011cited by this paper
• Epithelial—mesenchymal transdifferentiation of renal tubular epithelial cells induced by urinary proteins requires the activation of PKC‐α and βI isozymes

  2011cited by this paper
• Blocking TGF-β1 protects the peritoneal membrane from dialysate-induced damage.

  2011cited by this paper
• Therapeutic Potential for Protein Kinase C Inhibitor in Vascular Restenosis

  2011cited by this paper
• Regulation of endothelial cell plasticity by TGF-β

  2011cited by this paper
• PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium.

  2010cited by this paper
• The pathophysiology of the peritoneal membrane.

  2010cited by this paper
• PPAR-γ agonist rosiglitazone protects peritoneal membrane from dialysis fluid-induced damage

  2010cited by this paper
• BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure.

  2010cited by this paper
• Podocytic PKC-Alpha Is Regulated in Murine and Human Diabetes and Mediates Nephrin Endocytosis

  2010cited by this paper
• IL-17–Mediated Monocyte Migration Occurs Partially through CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Induction

  2010cited by this paper
• Cyclooxygenase-2 mediates dialysate-induced alterations of the peritoneal membrane.

  2009cited by this paper
• PKC-alpha Modulates TGF-β Signaling and Impairs Podocyte Survival

  2009cited by this paper
• Protein kinase C α promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor

  2008cited by this paper
• Regulation of CCN2/CTGF and related cytokines in cultured peritoneal cells under conditions simulating peritoneal dialysis.

  2008cited by this paper
• Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor.

  2008cited by this paper
• Characterization of Epithelial-to-Mesenchymal Transition of Mesothelial Cells in a Mouse Model of Chronic Peritoneal Exposure to High Glucose Dialysate

  2008cited by this paper
• Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function.

  2007cited by this paper
• A combination of a PPAR-gamma agonist and an angiotensin II receptor blocker attenuates proinflammatory signaling and stimulates expression of Smad7 in human peritoneal mesothelial cells.

  2007cited by this paper
• Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions.

  2007cited by this paper
• Transgenic Mouse Models

  2007cited by this paper
• Modality options for renal replacement therapy: The integrated care concept revisited

  2006cited by this paper
• Prednisolone inhibits hyperosmolarity-induced expression of MCP-1 via NF-kappaB in peritoneal mesothelial cells.

  2006cited by this paper
• Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts.

  2005cited by this paper
• Transient overexpression of TGF-{beta}1 induces epithelial mesenchymal transition in the rodent peritoneum.

  2005cited by this paper
• Protein Kinase Cα-Mediated Chemotaxis of Neutrophils Requires NF-κB Activity but Is Independent of TNFα Signaling in Mouse Skin In Vivo1

  2005cited by this paper
• [Epithelial-mesenchymal transition in fibrosing processes. Mesothelial cells obtained ex vivo from patients treated with peritoneal dialysis as transdifferentiation model].

  2004cited by this paper
• Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice.

  2004cited by this paper
• Immunohistochemical characterization of fibroblast subpopulations in normal peritoneal tissue and in peritoneal dialysis-induced fibrosis

  2004cited by this paper
• Differentiation of vascular myofibroblasts induced by transforming growth factor-beta1 requires the involvement of protein kinase Calpha.

  2003cited by this paper
• Myofibroblastic conversion of mesothelial cells.

  2003cited by this paper
• Glucose-induced TGF-beta1 and TGF-beta receptor-1 expression in vascular smooth muscle cells is mediated by protein kinase C-alpha.

  2003cited by this paper
• Differentiation of vascular myofibroblasts induced by transforming growth factor-β1 requires the involvement of protein kinase Cα

  2003cited by this paper
• Glucose-Induced TGF-&bgr;1 and TGF-&bgr; Receptor-1 Expression in Vascular Smooth Muscle Cells Is Mediated by Protein Kinase C-&agr;

  2003cited by this paper
• Morphologic changes in the peritoneal membrane of patients with renal disease.

  2002cited by this paper
• Knockout of PKC alpha enhances insulin signaling through PI3K.

  2002cited by this paper
• Knockout of PKC Enhances Insulin Signaling Through PI3K

  2002cited by this paper
• Vascular endothelial growth factor (VEGF) levels in peritoneal dialysis effluent.

  2001cited by this paper
• High glucose–induced PKC activation mediates TGF-β1 and fibronectin synthesis by peritoneal mesothelial cells

  2001cited by this paper
• Effect of High Glucose Concentration on the Synthesis of Monocyte Chemoattractant Protein-1 in Human Peritoneal Mesothelial Cells: Involvement of Protein Kinase C

  2001cited by this paper
• Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function.

  2001cited by this paper
• High glucose-induced PKC activation mediates TGF-beta 1 and fibronectin synthesis by peritoneal mesothelial cells.

  2001cited by this paper
• Gene Transfer of Transforming Growth Factor- 1 to the Rat Peritoneum: Effects on Membrane Function

  2001cited by this paper
• Leukocyte migration across human peritoneal mesothelial cells is dependent on directed chemokine secretion and ICAM-1 expression.

  1998cited by this paper

• Parthenolide Alleviates Peritoneal Fibrosis by Blocking Smad2/3 Phosphorylation via Smad Anchor for Receptor Activation

  2026cites this paper
• Eupalinolide B Ameliorates Liver Fibrosis by Targeting PKCα to Suppress the AKT/mTOR Axis in Hepatic Stellate Cells.

  2026cites this paper
• Metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis–associated fibrosis: therapeutic targets and strategies

  2025cites this paper
• Troxerutin is a novel osmotic agent for peritoneal dialysis with protective cardiovascular actions.

  2025cites this paper
• Nicotinamide nucleotide transhydrogenase deficiency and genetic susceptibility to high glucose‐mediated peritoneal injury in mice

  2025cites this paper
• Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme

  2024cites this paper
• Mechanisms underlying the involvement of peritoneal macrophages in the pathogenesis and novel therapeutic strategies for dialysis-induced peritoneal fibrosis

  2024cites this paper
• Therapeutic Potential of Oligo-Fucoidan in Mitigating Peritoneal Dialysis-Associated Fibrosis

  2024cites this paper
• Sterile inflammation of peritoneal membrane caused by peritoneal dialysis: focus on the communication between immune cells and peritoneal stroma

  2024cites this paper
• Hyperglycolysis in endothelial cells drives endothelial injury and microvascular alterations in peritoneal dialysis

  2023cites this paper
• A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis

  2023cites this paper
• Novel Aspects of the Immune Response Involved in the Peritoneal Damage in Chronic Kidney Disease Patients under Dialysis

  2023cites this paper
• Inflammatory chemokine (C‐C motif) ligand 8 inhibition ameliorates peritoneal fibrosis

  2022cites this paper
• Fibrosis of Peritoneal Membrane as Target of New Therapies in Peritoneal Dialysis

  2022cites this paper
• Monocyte chemoattractant protein‐1 predicts the development of diabetic nephropathy

  2021cites this paper
• Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-β/Smad signaling.

  2021cites this paper
• Nestin+ Cells Isolated From The Peritoneum Attenuate Peritoneal Fibrosis Via Suppressing IL-33 /ST2 Signaling

  2020cites this paper
• Urokinase receptor associates with TLR4 interactome to promote LPS response

  2020cites this paper
• Molecular pathways in peritoneal fibrosis.

  2020cites this paper
• SGLT2 Inhibition by Intraperitoneal Dapagliflozin Mitigates Peritoneal Fibrosis and Ultrafiltration Failure in a Mouse Model of Chronic Peritoneal Exposure to High-Glucose Dialysate

  2020influential citation
• TLR4 Response to LPS Is Reinforced by Urokinase Receptor

  2020cites this paper
• CX3CL1-CX3CR1 interaction mediates macrophage-mesothelial cross talk and promotes peritoneal fibrosis.

  2019cites this paper
• Activation of General Control Nonderepressible-2 Kinase Ameliorates Glucotoxicity in Human Peritoneal Mesothelial Cells, Preserves Their Integrity, and Prevents Mesothelial to Mesenchymal Transition

  2019cites this paper
• Advanced Oxidation Protein Products Aggravate Tubulointerstitial Fibrosis Through Protein Kinase C-Dependent Mitochondrial Injury in Early Diabetic Nephropathy

  2019cites this paper
• Rapamycin inhibits peritoneal fibrosis by modifying lipid homeostasis in the peritoneum.

  2019cites this paper
• Inhibiting core fucosylation attenuates glucose-induced peritoneal fibrosis in rats.

  2018cites this paper
• Mammalian Target of Rapamycin Complex 1 Activation Disrupts the Low-Density Lipoprotein Receptor Pathway: A Novel Mechanism for Extracellular Matrix Accumulation in Human Peritoneal Mesothelial Cells

  2018cites this paper
• Protein kinase C beta deficiency increases glucose-mediated peritoneal damage via M1 macrophage polarization and up-regulation of mesothelial protein kinase C alpha.

  2018cites this paper
• PKC-α Triggers EGFR Ubiquitination, Endocytosis and ERK Activation in Podocytes Stimulated with High Glucose

  2017cites this paper
• Unraveling the mechanisms of progressive peritoneal membrane fibrosis.

  2016cites this paper