DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Oncogene

• Publication date

  2005-11-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1208875PMID 16044158
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The JNK signal transduction pathway.

  2007cited by this paper
• Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress.

  2004cited by this paper
• Mitogen-activated protein kinase (MAPK) phosphatase-1 and -4 attenuate p38 MAPK during dexamethasone-induced insulin resistance in 3T3-L1 adipocytes.

  2004cited by this paper
• UV Light-induced DNA Damage and Tolerance for the Survival of Nucleotide Excision Repair-deficient Human Cells*

  2004cited by this paper
• Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes.

  2004cited by this paper
• MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence

  2004cited by this paper
• Inhibition of MKP-1 expression potentiates JNK related apoptosis in renal cancer cells.

  2004cited by this paper
• Structure and regulation of MAPK phosphatases.

  2004cited by this paper
• c-Jun-Deficient Cells Undergo Premature Senescence as a Result of Spontaneous DNA Damage Accumulation

  2004cited by this paper
• The Ubiquitin Ligase SCFFbw7 Antagonizes Apoptotic JNK Signaling

  2004cited by this paper
• Cellular defense against H2O2-induced apoptosis via MAP kinase-MKP-1 pathway.

  2004cited by this paper
• ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest

  2004cited by this paper
• Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines.

  2003cited by this paper
• Mechanism of p38 MAP kinase activation in vivo.

  2003cited by this paper
• The Activation of c-Jun NH2-terminal Kinase (JNK) by DNA-damaging Agents Serves to Promote Drug Resistance via Activating Transcription Factor 2 (ATF2)-dependent Enhanced DNA Repair*

  2003cited by this paper
• Divide and conquer: nucleotide excision repair battles cancer and ageing.

  2003cited by this paper
• Regulation of MAP kinase signaling modules by scaffold proteins in mammals.

  2003influential reference
• JunD mediates survival signaling by the JNK signal transduction pathway.

  2003cited by this paper
• Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2

  2003cited by this paper
• JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

  2003cited by this paper
• ATF3 Represses 72-kDa Type IV Collagenase (MMP-2) Expression by Antagonizing p53-dependent trans-Activation of the Collagenase Promoter*

  2002cited by this paper
• Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways.

  2002cited by this paper
• The JNK signal transduction pathway.

  2002cited by this paper
• Transcription repair coupling factor: a very pushy enzyme.

  2002cited by this paper
• Ultraviolet-sensitive syndrome cells are defective in transcription-coupled repair of cyclobutane pyrimidine dimers.

  2002cited by this paper
• AP-1 as a regulator of cell life and death

  2002cited by this paper
• The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH2-Terminal Kinase

  2002cited by this paper
• Cellular response to oxidative stress: Signaling for suicide and survival *

  2002cited by this paper
• Distinct Binding Determinants for ERK2/p38α and JNK MAP Kinases Mediate Catalytic Activation and Substrate Selectivity of MAP Kinase Phosphatase-1* 210

  2001cited by this paper
• Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent‐induced apoptosis

  2001cited by this paper
• Mammalian MAP kinase signalling cascades

  2001cited by this paper
• DNA microarrays identification of primary and secondary target genes regulated by p53

  2001cited by this paper
• AP-1 in cell proliferation and survival

  2001cited by this paper
• P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts

  2001influential reference
• Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis

  2001cited by this paper
• Transcriptional Induction of MKP-1 in Response to Stress Is Associated with Histone H3 Phosphorylation-Acetylation

  2001cited by this paper
• Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription.

  2001cited by this paper
• Effects of XPD mutations on ultraviolet-induced apoptosis in relation to skin cancer-proneness in repair-deficient syndromes.

  2001cited by this paper
• An Analysis of Lyocell Fiber Formation as a Melt–spinning Process

  2001cited by this paper
• Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

  2000cited by this paper
• CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin

  2000cited by this paper
• Nucleotide excision repair and human syndromes.

  2000cited by this paper
• UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II.

  2000cited by this paper
• Signal transduction by the JNK group of MAP kinases.

  2000cited by this paper
• Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis.

  2000cited by this paper
• UV-Induced Stabilization of c-fos and Other Short-Lived mRNAs

  2000cited by this paper
• Printed in U.S.A. Copyright © 2000 by The Endocrine Society Insulin-Mediated Cell Proliferation and Survival Involve Inhibition of c-Jun N-terminal Kinases through a Phosphatidylinositol 3-Kinase- and Mitogen-Activated Protein Kinase Phosphatase-1-Depende

  1999cited by this paper
• Radiation-induced signal transduction. Mechanisms and consequences.

  1999cited by this paper
• Xeroderma pigmentosum and the role of UV-induced DNA damage in skin cancer.

  1999cited by this paper
• Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

  1999cited by this paper
• NF-κB as a primary regulator of the stress response

  1999cited by this paper
• NF-kappaB as a primary regulator of the stress response.

  1999cited by this paper
• Cyclic Strain Stress-induced Mitogen-activated Protein Kinase (MAPK) Phosphatase 1 Expression in Vascular Smooth Muscle Cells Is Regulated by Ras/Rac-MAPK Pathways*

  1999cited by this paper
• Cisplatin induces a persistent activation of JNK that is related to cell death

  1998cited by this paper
• Photoproducts in transcriptionally active DNA induce signal transduction to the delayed U.V.-responsive genes for collagenase and metallothionein

  1998cited by this paper
• Impaired DNA repair capacity in skin fibroblasts from various hereditary cancer-prone syndromes.

  1998cited by this paper
• Inhibition of the Expression of Mitogen-activated Protein Phosphatase-1 Potentiates Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells*

  1998cited by this paper
• Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis

  1998cited by this paper
• Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis.

  1998cited by this paper
• Induction of apoptosis by the transcription factor c‐Jun

  1997cited by this paper
• Conditional Expression of the Mitogen-activated Protein Kinase (MAPK) Phosphatase MKP-1 Preferentially Inhibits p38 MAPK and Stress-activated Protein Kinase in U937 Cells*

  1997cited by this paper
• Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

  1996cited by this paper
• Role of Mitogen-activated Protein Kinase Phosphatase during the Cellular Response to Genotoxic Stress

  1995cited by this paper
• Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.

  1995cited by this paper
• Fos is an essential component of the mammalian UV response.

  1995cited by this paper
• Involvement of growth factor receptors in the mammalian UVC response.

  1994cited by this paper
• Heterodimer formation of cJun and ATF‐2 is responsible for induction of c‐jun by the 243 amino acid adenovirus E1A protein.

  1993cited by this paper
• High levels of enhanced reactivation of herpes simplex virus in skin fibroblasts from various hereditary cancer-prone syndromes.

  1992cited by this paper
• Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

  1992cited by this paper
• Transformation and immortalization of diploid xeroderma pigmentosum fibroblasts.

  1990cited by this paper
• Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.

  1985cited by this paper

• Interactions between LncRNAs and MAPK signaling pathways in the pathogenesis of breast cancer

  2025cites this paper
• Transcription Factors, Nucleotide Excision Repair, and Cancer: A Review of Molecular Interplay.

  2024cites this paper
• Phosphorylation of Bcl‐2 by JNK confers gemcitabine resistance in lung cancer cells by reducing autophagy‐mediated cell death

  2023cites this paper
• Paraquat and Parkinson’s Disease: The Molecular Crosstalk of Upstream Signal Transduction Pathways Leading to Apoptosis

  2023cites this paper
• Towards targeting of shared mechanisms of cancer metastasis and therapy resistance

  2022cites this paper
• Genetic perturbation of MAPK11 (p38 β ) promotes radiosensitivity by enhancing IR-associated senescence.

  2022cites this paper
• Toxicities of amyloid-beta and tau protein are reciprocally enhanced in the Drosophila model

  2022cites this paper
• Photothermal Killing of A549 Cells and Autophagy Induction by Bismuth Selenide Particles

  2021cites this paper
• JNK Pathway in CNS Pathologies

  2021cites this paper
• miR-128 regulated the proliferation and autophagy in porcine adipose-derived stem cells through targeting the JNK signaling pathway

  2020cites this paper
• JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

  2019cites this paper
• Probiotic Bacillus Attenuates Oxidative Stress- Induced Intestinal Injury via p38-Mediated Autophagy

  2019cites this paper
• Inflammation induces endothelial‐to‐mesenchymal transition and promotes vascular calcification through downregulation of BMPR2

  2019cites this paper
• Phosphorylation of eIF2α promotes cell survival in response to benzo[a]pyrene exposure.

  2019cites this paper
• Effect of heterochromatin stability on intestinal stem cell aging in Drosophila.

  2018cites this paper
• Resting T cells are hypersensitive to DNA damage due to defective DNA repair pathway

  2018cites this paper
• Transcriptional Study Revealed That Boron Supplementation May Alter the Immune-Related Genes Through MAPK Signaling in Ostrich Chick Thymus

  2018cites this paper
• Salvianolic acid B inhibits the development of diabetic peripheral neuropathy by suppressing autophagy and apoptosis

  2018cites this paper
• Notch1 regulates the JNK signaling pathway and increases apoptosis in hepatocellular carcinoma

  2017cites this paper
• Gain And Loss Of Progranulin Have Opposite Effects On Autophagy

  2017cites this paper
• MKP-1 suppresses PARP-1 degradation to mediate cisplatin resistance

  2017cites this paper
• Transcription coupled repair deficiency protects against human mutagenesis and carcinogenesis: Personal Reflections on the 50th anniversary of the discovery of xeroderma pigmentosum.

  2017cites this paper
• DNA Damage Response and Autophagy: A Meaningful Partnership

  2016cites this paper
• Retargeted adenoviruses for radiation-guided gene delivery

  2016cites this paper
• Why Cockayne syndrome patients do not get cancer despite their DNA repair deficiency

  2016cites this paper
• MUTYH promotes oxidative microglial activation and inherited retinal degeneration.

  2016cites this paper
• Highly accurate RNA and DNA sequencing: Application to longstanding questions in aging and cancer

  2016cites this paper
• DNA damage and the balance between survival and death in cancer biology

  2015cites this paper
• Molecular histology of lung cancer: from targets to treatments.

  2015cites this paper
• Role of acetylcholinesterase in lung cancer

  2015cites this paper
• Chapter 7 Compelling insight into DIO 2 function during human in vitro chondrogenesis ; towards underlying mechanisms of OA susceptibility

  2015cites this paper
• c‐Jun NH2‐terminal kinases in liver diseases

  2015cites this paper
• MLK3 Phophorylates AMPK Independently of LKB1

  2015cites this paper
• MAPK/JNK signalling: a potential autophagy regulation pathway

  2015cites this paper
• The Immunogenic Effect of Local Radiation Therapy in a Murine Model of Mesothelioma

  2015cites this paper
• Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

  2014cites this paper
• Interleukin-1β Enhances FasL-Induced Caspase-3/-7 Activity without Increasing Apoptosis in Primary Mouse Hepatocytes

  2014cites this paper
• Linking JNK Activity to the DNA Damage Response.

  2013cites this paper
• DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis.

  2013cites this paper
• Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: a new approach with future therapeutic potential.

  2013cites this paper
• Cancer Treatment with Gene Therapy and Radiation Therapy

  2013cites this paper
• Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptation

  2013cites this paper
• ATR and MKP1 play distinct roles in response to UV-B stress in Arabidopsis.

  2013cites this paper
• Overexpressed DNA Polymerase Iota Regulated by JNK/c-Jun Contributes to Hypermutagenesis in Bladder Cancer

  2013cites this paper
• Involvement of ROS in the inhibitory effect of thermotherapy combined with chemotherapy on A549 human lung adenocarcinoma cell growth through the Akt pathway.

  2012cites this paper
• Chapter seven--Cancer treatment with gene therapy and radiation therapy.

  2012cites this paper
• Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice.

  2012cites this paper
• Over-expression of map kinase phosphatase-1 (MKP-1) suppresses neuronal death through regulating JNK signaling in hypoxia/re-oxygenation.

  2012cites this paper
• DUSP6 is a novel transcriptional target of p53 and regulates p53‐mediated apoptosis by modulating expression levels of Bcl‐2 family proteins

  2012cites this paper
• The effect of MKP-1 inhibition on the cytotoxicity of chemotherapeutic drugs in breast cancer

  2012cites this paper
• Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells*

  2011cites this paper
• Mechanisms of High Glucose-induced Decrease in β-cell Function

  2011cites this paper
• JNKs in liver diseases

  2010cites this paper
• DNA Damage Response and the Balance Between Cell Survival and Cell Death

  2010cites this paper
• Oxidative Modification of Nuclear Mitogen-activated Protein Kinase Phosphatase 1 Is Involved in Transforming Growth Factor β1-induced Expression of Plasminogen Activator Inhibitor 1 in Fibroblasts*

  2010cites this paper
• DNA replication arrest in response to genotoxic stress provokes early activation of stress-activated protein kinases (SAPK/JNK).

  2009cites this paper
• The anti-apoptotic role for p53 following exposure to ultraviolet light does not involve DDB2.

  2009cites this paper
• A transcription co-factor integrates cell adhesion and motility with the p53 response

  2009cites this paper
• Glucocorticoid-mediated apoptosis resistance of solid tumors.

  2009cites this paper
• Association and impact of XPG Asp 1104 His gene polymorphism in HIV 1 disease progression to AIDS among north Indian HIV seropositive individuals

  2009cites this paper
• KLF5 Promotes Breast Cell Survival Partially through Fibroblast Growth Factor-binding Protein 1-pERK-mediated Dual Specificity MKP-1 Protein Phosphorylation and Stabilization*

  2009cites this paper
• The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells

  2009cites this paper
• The complexity of signaling in host-pathogen interactions revealed by the Toxoplasma gondii-dependent modulation of JNK phosphorylation.

  2008cites this paper
• DNA Damage, Apoptosis and Langerhans Cells—Activators of UV‐induced Immune Tolerance †

  2008cites this paper
• Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer

  2008cites this paper
• Negative charged threonine 95 of c-Jun is essential for c-Jun N-terminal kinase-dependent phosphorylation of threonine 91/93 and stress-induced c-Jun biological activity.

  2008cites this paper
• ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses.

  2008cites this paper
• Maintenance of tissue homeostasis by receptor tyrosine kinase (RTK) and Jun-N-terminal Kinase (JNK)

  2008cites this paper
• Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response.

  2008cites this paper
• Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II

  2008cites this paper
• Regulation of differential pro- and anti-apoptotic signaling by glucocorticoids

  2007cites this paper
• Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation

  2007cites this paper
• Cockayne syndrome exhibits dysregulation of p21 and other gene products that may be independent of transcription-coupled repair.

  2007cites this paper
• Regulation of innate immunity by MAPK dual‐specificity phosphatases: knockout models reveal new tricks of old genes

  2007cites this paper
• A role for UV-light-induced c-Fos: Stimulation of nucleotide excision repair and protection against sustained JNK activation and apoptosis.

  2007cites this paper
• Radiation to control transgene expression in tumors

  2007cites this paper
• The case for 8,5'-cyclopurine-2'-deoxynucleosides as endogenous DNA lesions that cause neurodegeneration in xeroderma pigmentosum.

  2007cites this paper
• Genome wide analysis of dna repair by expression profiling

  2006cites this paper
• 2-Methoxyestradiol , an EndogenousMammalianMetabolite , Radiosensitizes Colon Carcinoma Cells through c-Jun NH 2-Terminal KinaseActivation

  2006cites this paper
• Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis

  2006cites this paper
• 2-Methoxyestradiol, an Endogenous Mammalian Metabolite, Radiosensitizes Colon Carcinoma Cells through c-Jun NH2-Terminal Kinase Activation

  2006cites this paper
• Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling.

  2006cites this paper
• Macrophage-Colony-Stimulating Factor-Induced Proliferation and Lipopolysaccharide-Dependent Activation of Macrophages Requires Raf-1 Phosphorylation to Induce Mitogen Kinase Phosphatase-1 Expression1

  2006cites this paper
• Cockayne Syndrome Mouse Models: linking impaired DNA repair and premature aging

  2006cites this paper
• Regulation of MAPK phosphatase expression in the prostate cancer cell line LNCaP : Possible role in apoptosis

  2005cites this paper
• The JNK signal transduction pathway.

  2002cites this paper