ON THE METABOLISM OF HISTAMINE. A. URINARY EXCRETION FOLLOWING ORAL ADMINISTRATION. B. CONJUGATION IN VITRO

The excretion of free and conjugated histamine in the urine has been determined after oral administration to mice, rats, rabbits, guinea pigs, and dogs. In mice and rats up to 37 per cent of the administered dose could be recovered largely in the free form. In the other species from 3 to 20 per cent was recovered chiefly as conjugated histamine. Rabbit and pigeon liver slices in vitro were capable of conjugation of histamine. Conjugation was also obtained with a cell free extract prepared from an acetone powder of pigeon liver; with this preparation it was shown that coenzyme A is required for the process.

• Publication year

  1949

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  1949-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0022-3565(25)03624-9
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• No references are available for this paper.

• Methods for determination of coenzyme A.

  2006cites this paper
• Stoffwechsel und physiologische Funktion von Histamin im Magen

  2005cites this paper
• Untersuchungen zum Histaminstoffwechsel im Kindesalter

  2004cites this paper
• A new histamine metabolite, quantitatively important in chicken

  1977cites this paper
• CHEMISTRY OF BIOLOGICALLY ACTIVE SULFUR COMPOUNDS

  1976cites this paper
• Absorption and catabolism of histamine in sheep

  1974cites this paper
• Determination and Occurrence of Free and Conjugated Histamine in Urine of Sheep

  1970cites this paper
• The in vitro catabolism of histamine by sheep liver tissue.

  1967cites this paper
• In Vitro Metabolism of Histamine (Exclusive of Diamine Oxidase)

  1966cites this paper
• Absorption de l’histamine par l’appareil digestif

  1966cites this paper
• Oxydo-Reductasen (Fortsetzung)

  1966cites this paper
• Coenzym A-Enzyme

  1966cites this paper
• Untersuchungen zum Histaminstoffwechsel im Kindesalter

  1966cites this paper
• Physiological Significance of the Effect of Histamine on Gastric Secretion

  1966cites this paper
• L’excrétion de l’histamine

  1966cites this paper
• The enzymic acetylation of serotonin and other naturally ocurring amines

  1961cites this paper
• Toxicity to chicks of histamine formed during microbial spoilage of tuna.

  1959cites this paper
• Die biogenen Amine in der Pflanzenwelt

  1958cites this paper
• Biological Significance of Choline Acetylase **

  1957cites this paper
• [90] Isolation and determination of histidine and related compounds

  1957cites this paper
• Histamine and its derivatives in human urine.

  1957cites this paper
• Physiologische Chemie einzelner Lebensvorgänge und Organe (Fortsetzung)

  1956cites this paper
• Alteration of certain pharmacological effects of histamine by selected histaminase inhibitors

  1956cites this paper
• Factors influencing the urinary excretion of histamine in the rat

  1954cites this paper
• Der oxydative Endabbau

  1954cites this paper
• Chemistry and physiology of mitochondria and microsomes

  1954cites this paper
• The metabolism of histamine as reflected by changes in its urinary excretion in the rat

  1954cites this paper
• FUNDAMENTAL ASPECTS OF ALLERGY

  1954cites this paper
• The Role of Sulfhydryl Compounds in Acyl-Transfer Reactions

  1954cites this paper
• ON CHEMISTRY AND FUNCTION OF COENZYME A

  1953cites this paper
• The acetylation of histamine in normal and enterectomized rats.

  1953cites this paper
• Metabolism of amino acids and proteins.

  1952cites this paper