Active site directed inhibitors and mechanism of action of glycosidases

No abstract is available for this paper.

• Publication year

  1973

• Venue

  Molecular and Cellular Biochemistry

• Publication date

  1973-11-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/BF01738676PMID 4587538
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Thesis

  2002cited by this paper
• Untersuchungen zum Wirkungsmechanismus glykosidspaltender Enzyme, VII. Funktionelle Gruppen am aktiven Zentrum einer α-Glucosidase aus Saccharomyces cerevisiae

  1973cited by this paper
• [Investigations on the mechanism of action of glycoside splitting enzymes. VII. Functional groups at the active site of an alpha-glucosidase from Saccharomyces cerevisiae (author's transl)].

  1973cited by this paper
• Reversible alkylation of a methionyl residue near the active site of -galactosidase.

  1972cited by this paper
• General acid catalysis of acetal, ketal, and ortho ester hydrolysis

  1972cited by this paper
• The synthesis of 1L-1,2-anhydro-myo-inositol and 1L- and DL-1,2-anhydro-chiro-inositol

  1971cited by this paper
• Houdings teenoor die Suid-Afrikaanse immigrasiebeleid

  1971cited by this paper
• Untersuchungen zum Wirkungsmechanismus glykosidspaltender Enzyme, VI. Zur Kenntnis der katalytisch wirkenden Gruppen einer β-Glucosidase aus Aspergillus wentii

  1970cited by this paper
• Untersuchungen zum Wirkungsmechanismus glykosidspaltender Enzyme, V. Markierung des aktiven Zentrums der β-Glucosidasen A und B aus dem Süßmandel-Emulsin mit [3H]6-Brom-6-desoxy-condurit-B-epoxid

  1970cited by this paper
• Studies on the Interaction of the Inhibitor O‐Mercuriphenyl β‐d‐Galactoside Chloride with β‐Galactosidase from Escherichia coli K12

  1970cited by this paper
• [Mechanism of action of glycoside-splitting enzymes. V. Labelling of the active center of beta-glucosidases A and B from sweet almond emulsin with (3H)6-bromo-6-deoxyconduritol B epoxide].

  1970cited by this paper
• Studies on the interaction of the inhibitor o-mercuriphenyl beta-D-galactoside chloride with beta-galactosidase from Escherichiacoli K 12.

  1970cited by this paper
• [On the mechanism of action of glycoside-splitting enzymes. VI. Catalytically active groups of a beta-glucosidase from Aspergillus wentii].

  1970cited by this paper
• Kinetic studies of the action of cellulase upon sodium carboxymethyl cellulose.

  1969cited by this paper
• Application of secondary alpha-deuterium kinetic isotope effects to studies of enzyme catalysis. Glycoside hydrolysis by lysozyme and beta-glucosidase.

  1969cited by this paper
• States of amino acid residues in proteins. 18. A revised way of using diazonium-I-H-tetrazole for reactivity examination of histidine and tyrosine residues.

  1969cited by this paper
• Specific and Irreversible Inhibition of Lysozyme by 2′,3′-Epoxypropyl β-Glycosides of N-Acetyl-D-glucosamine Oligomers

  1969cited by this paper
• Transition State Analogues for Enzyme Catalysis

  1969cited by this paper
• Untersuchungen zum Wirkungsmechanismus glykosidspaltender Enzyme, IV. Reinigung und Eigenschaften einer β-Glucosidase aus Aspergillus oryzae

  1968cited by this paper
• [Isolation, purification and some physicochemical characteristics of 2 beta-hexosidases of the digestive juice of Helix pomatia].

  1968cited by this paper
• On distinguishing between possible mechanistic pathways during lysozyme-catalyzed cleavage of glycosidic bonds.

  1968cited by this paper
• [Mechanism of action of glycoside splitting enzymes. IV. Purification and properties of a beta-glucosidase from Aspergillus oryzae].

  1968cited by this paper
• [Investigations on the mechanism of action of glycoside-splitting enzymes. 3. Labelling of the active center of a beta-glucosidase from Aspergillus wentii with (14C) conduritol B epoxide].

  1968cited by this paper
• Labelling of the active centre of a beta-glucosidase.

  1968cited by this paper
• Isolement, purification et quelques caractéristiques physicochimiques de deux β‐hexosidases du suc digestif d'Helix pomatia

  1968cited by this paper
• Zur Kenntnis des Süßmandel-Emulsins

  1968cited by this paper
• Untersuchungen zum Wirkungsmechanismus glykosidspaltender Enzyme, III. Markierung des aktiven Zentrums einer β-Glucosidase aus Aspergillus wentii mit [14C]Condurit-B-epoxid

  1968cited by this paper
• [Studies on the mechanism of action of glycoside-splitting enzymes, II. Isolation and enzymatic properties of 2 beta-glucosidases from Aspergillus wentii].

  1967cited by this paper
• Crystallographic studies of the activity of hen egg-white lysozyme

  1967cited by this paper
• Untersuchungen zum Wirkungsmechanismus glykosidspaltender Enzyme, II. Isolierung und enzymatische Eigenschaften von zwei β-Glucosidasen aus Aspergillus wentii

  1967cited by this paper
• Design of Active-Site-Directed Irreversible Enzyme Inhibitors.

  1967cited by this paper
• Inhibition of glycosidases by aldonolactones of corresponding configuration: Preparation of (1-->5)-lactones by catalytic oxidation of pyranoses and study of their inhibitory properties.

  1967cited by this paper
• Acid-catalyzed hydrolysis of glycosides.

  1967cited by this paper
• Acid-catalyzed hydrolysis of glycosides.

  1967cited by this paper
• Untersuchungen zum Wirkungsmechanismus glykosidspaltender Enzyme, I. Darstellung und Eigenschaften spezifischer Inaktivatoren

  1966cited by this paper
• [Studies on the action mechanism of glycoside splitting anzymes, I. Presentation and properties of specific inhibitors].

  1966cited by this paper
• PURIFICATION, COMPOSITION, AND MOLECULAR WEIGHT OF THE BETA-GALACTOSIDASE OF ESCHERICHIA COLI K12.

  1965cited by this paper
• [Data on sweet almond emulsin].

  1965cited by this paper
• The Enzymes

  1961cited by this paper
• [Research on lactose-splitting enzymes. VII. The specificity of beta-galactosidase from E. coli ML 309].

  1960cited by this paper
• Hydrolysis of a series of beta-1,4'-oligoglucosides by Myrothecium verrucaria cellulase.

  1954cited by this paper
• Debromination of Inositol Bromohydrins.* Synthesis of “Conduritol-B,” scylloQuercitol, and D,L-viboQuercitol1,2

  1953cited by this paper
• Ueber die Bildung des Bittermandelöls

  year unknowncited by this paper

• Metabolomic Profile of Weaned Pigs Challenged with E. coli and Supplemented with Carbadox or Bacillus subtilis

  2021cites this paper
• Cyclization Reactions of Aryl Propargyl Acetates with Tethered Epoxide Induced by Ruthenium Complex.

  2017cites this paper
• A unified and common intermediate strategy for the asymmetric total synthesis of 3-deoxy-neo-inositol and conduritol E

  2016cites this paper
• Bone Marrow Microenvironment in an In Vitro Model of Gaucher Disease: Consequences of Glucocerebrosidase Deficiency

  2012cites this paper
• Stereoselective synthesis of polyhydroxylated aminocyclohexanes.

  2011cites this paper
• Efficient Synthesis of Optically Pure (+)-Bezene Diol Epoxide and (+)-Conduramine A-1

  2010cites this paper
• Isolation and Amino Acid Sequence of a Hexadecapeptide from the Active Site of ß-Glucosidase A3 from Aspergillus wentii

  2009cites this paper
• Chemoenzymatic Synthesis and Biological Evaluation of (−)‐Conduramine C‐4

  2007cites this paper
• Synthesis of Both Enantiomers of Conduritol C Tetraacetate and of meso-Conduritol D Tetraacetate by Oxidation of Benzoquinone Bis(ethylene acetal)

  2007cites this paper
• Glycosidases--properties and application to the study of complex carbohydrates and cell surfaces.

  2006cites this paper
• α- and β-Glucosidase inhibitors: chemical structure and biological activity

  2006cites this paper
• A general procedure for the synthesis of stereochemically pure conduritol derivatives practical also for solid-phase chemistry.

  2006cites this paper
• A concise synthetic route to the conduritols from pentoses.

  2005cites this paper
• Effects of Tunicamycin, Mannosamine, and Other Inhibitors of Glycoprotein Processing on Skeletal Alkaline Phosphatase in Human Osteoblast-Like Cells

  2004cites this paper
• Inhibitory activity of corn-derived bisamide compounds against alpha-glucosidase.

  2003cites this paper
• Facile syntheses of all possible diastereomers of conduritol and various derivatives of inositol stereoisomers in high enantiopurity from myo-inositol.

  2002cites this paper
• Facile synthetic routes to all possible enantiomeric pairs of conduritol stereoisomers via efficient enzymatic resolution of conduritol B and C derivatives.

  2001cites this paper
• Modern Methods of Monosaccharide Synthesis from Non-Carbohydrate Sources.

  1996cites this paper
• Calystegins of Physalis alkekengi var. francheti (Solanaceae). Structure determination and their glycosidase inhibitory activities.

  1995cites this paper
• Human lysosomal alpha-glucosidase. Characterization of the catalytic site.

  1991cites this paper
• Glycoside hydrolases: mechanistic information from studies with reversible and irreversible inhibitors.

  1990cites this paper
• Design of potential anti-HIV agents. 1. Mannosidase inhibitors.

  1989cites this paper
• The effect of glycerol on the activity of beta-glucosidase from Botryodiplodia theobromae Pat.

  1988cites this paper
• The mechanism of action of beta-glucosidase from Botryodiplodia theobromae Pat.

  1987cites this paper
• Studies on the turnover of glucocerebrosidase in cultured rat peritoneal macrophages and normal human fibroblasts.

  1986cites this paper
• Hydration of cellobial by exo- and endo-type cellulases: evidence for catalytic flexibility of glycosylases.

  1986cites this paper
• Reversible inhibitors of beta-glucosidase.

  1985cites this paper
• Use of activators and inhibitors to define the properties of the active site of normal and Gaucher disease lysosomal beta-glucosidase.

  1985cites this paper
• Human lysosomal beta-glucosidase: kinetic characterization of the catalytic, aglycon, and hydrophobic binding sites.

  1984cites this paper
• Identification of an essential carboxylate group at the active site of lacZ beta-galactosidase from Escherichia coli.

  1984cites this paper
• Studies on the mechanism of castanospermine inhibition of alpha- and beta-glucosidases.

  1984cites this paper
• Competitive inhibition of the inverting beta-xylosidase of Bacillus pumilus 12 by monosaccharide derivatives of different structural and conformational types. A possible natural substrate.

  1983cites this paper
• The use of inhibitors in the study of glycosidases.

  1982cites this paper
• Inactivation of beta-fucosidase by iodine, N-acetylimidazole and tetranitromethane. Evidence for the existence of essential tyrosine residues.

  1981cites this paper
• Active site‐directed inhibition of galactosidases by conduritol C epoxides (1,2‐anhydro‐EPI‐and NEO‐inositol

  1981cites this paper
• Distribution of conduritol B epoxide in the animal model for Gaucher's disease (Gaucher mouse).

  1981cites this paper
• Isolation and structure of a tryptic glycopeptide from the active site of beta-glucosidase A3 from Aspergillus wentii.

  1980cites this paper
• Temperature-dependent change in the rate-limiting step of beta-glucosidase catalysis.

  1980cites this paper
• The necessity of magnesium cation for acid assistance aglycone departure in catalysis by Escherichia coli (lacZ) beta-galactosidase.

  1978cites this paper
• Inhibition of beta-glucosidases from almonds by cationic and neutral beta-glucosyl derivatives.

  1978cites this paper
• Ions, ion-pairs and catalysis by the lacZ beta-galactosidase of Escherichia coli.

  1978cites this paper
• The differentiation of α- and β -glucosidase and α- and β-galactosidase isoenzymes from maize and broad bean root tips using disc electrophoresis in polyacrylamide gels

  1977cites this paper
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  1977cites this paper
• The inactivation of beta-galactosidase by N-bromoacetyl-beta-D-glucosylamine.

  1977cites this paper
• Synthesis and rearrangements of D-glucosyl esters of aspartic acid linked through the 1- or 4-carboxyl group.

  1976cites this paper
• The mechanism of action of glycosidases.

  1975cites this paper
• Cleavage of cardiac steroid glucosides by pure beta-glucosidase from Aspergillus ventii.

  1975cites this paper
• Inhibition of human liver beta-galactosidases and beta-glucosidase by n-bromoacetyl-beta-D-galactosylamine.

  1975cites this paper