A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  American Journal of Pathology

• Publication date

  2014-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ajpath.2013.12.011PMID 24486325
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 191st ENMC international workshop: recent advances in oculopharyngeal muscular dystrophy research: from bench to bedside 8-10 June 2012, Naarden, The Netherlands.

  2013cited by this paper
• A decline in PABPN1 induces progressive muscle weakness in Oculopharyngeal muscle dystrophy and in muscle aging

  2013cited by this paper
• Nuclear entrapment and extracellular depletion of PCOLCE is associated with muscle degeneration in oculopharyngeal muscular dystrophy

  2013cited by this paper
• PABPN1 shuts down alternative poly(A) sites

  2012cited by this paper
• Polyadenylation-Dependent Control of Long Noncoding RNA Expression by the Poly(A)-Binding Protein Nuclear 1

  2012cited by this paper
• Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R

  2012cited by this paper
• The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites.

  2012cited by this paper
• Overview on DMD exon skipping.

  2012cited by this paper
• Poly(A) binding protein nuclear 1 levels affect alternative polyadenylation

  2012cited by this paper
• Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.

  2011cited by this paper
• Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients

  2011cited by this paper
• Systemic administration of PRO051 in Duchenne's muscular dystrophy.

  2011cited by this paper
• Deconstruction for reconstruction: the role of proteolysis in neural plasticity and disease.

  2011cited by this paper
• Modeling oculopharyngeal muscular dystrophy in myotube cultures reveals reduced accumulation of soluble mutant PABPN1 protein.

  2011cited by this paper
• Reversible aggregation of PABPN1 pre-inclusion structures

  2011cited by this paper
• RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform.

  2010cited by this paper
• Molecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres.

  2010cited by this paper
• Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

  2010cited by this paper
• Guidelines for antisense oligonucleotide design and insight into splice-modulating mechanisms.

  2009cited by this paper
• Protein aggregation as a paradigm of aging.

  2009cited by this paper
• Targeting the Progression of Parkinson’s Disease

  2009cited by this paper
• Oculopharyngeal muscular dystrophy: A polyalanine myopathy

  2009cited by this paper
• Signaling in muscle atrophy and hypertrophy.

  2008cited by this paper
• Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin‐dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies

  2007cited by this paper
• The ring between ring fingers (RBR) protein family

  2007cited by this paper
• Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster.

  2007cited by this paper
• Prevention of oculopharyngeal muscular dystrophy-associated aggregation of nuclear polyA-binding protein with a single-domain intracellular antibody.

  2006cited by this paper
• Transcriptional Profiling of Aging in Human Muscle Reveals a Common Aging Signature

  2006cited by this paper
• Changes in lamina structure are followed by spatial reorganization of heterochromatic regions in caspase-8-activated human mesenchymal stem cells

  2006cited by this paper
• Premature proliferative arrest of cricopharyngeal myoblasts in oculo-pharyngeal muscular dystrophy: Therapeutic perspectives of autologous myoblast transplantation.

  2006cited by this paper
• Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle.

  2006cited by this paper
• Protein degradation by the ubiquitin-proteasome pathway in normal and disease states.

  2006cited by this paper
• Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

  2005cited by this paper
• Human muscle aging: ROS-mediated alterations in rectus abdominis and vastus lateralis muscles.

  2005cited by this paper
• Altered proteasome structure, function, and oxidation in aged muscle

  2005cited by this paper
• An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in Drosophila.

  2005cited by this paper
• Nuclear inclusion in oculopharyngeal dystrophy

  2004cited by this paper
• Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus.

  2004cited by this paper
• A Transcriptional Profile of Aging in the Human Kidney

  2004cited by this paper
• Comparative analysis of antisense oligonucleotide analogs for targeted DMD exon 46 skipping in muscle cells

  2004cited by this paper
• Gene regulation and DNA damage in the ageing human brain

  2004cited by this paper
• Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

  2004cited by this paper
• Involvement of the ubiquitin-proteasome pathway and molecular chaperones in oculopharyngeal muscular dystrophy.

  2003cited by this paper
• The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

  2003cited by this paper
• Impairment of the ubiquitin-proteasome system by protein aggregation.

  2001cited by this paper
• Fully modified 2' MOE oligonucleotides redirect polyadenylation.

  2001cited by this paper
• Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA.

  2000cited by this paper
• Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy

  1998cited by this paper
• Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy

  1998cited by this paper

• Oculopharyngeal muscular dystrophy (OPMD) associated alanine expansion impairs the function of the nuclear polyadenosine RNA binding protein PABPN1 as revealed by proximity labeling and comparative proteomics

  2026cites this paper
• Transcriptional regulation of porcine PABPN1 gene in adipogenesis

  2025cites this paper
• Oculopharyngeal muscular dystrophy (OPMD) associated alanine expansion impairs the function of the nuclear polyadenosine RNA binding protein PABPN1 as revealed by proximity labeling and comparative proteomics

  2025cites this paper
• Polyalanine Expansion in PABPN1 Alters the Structure and Dynamics of Its Nuclear Aggregates in Differentiated Muscle Cells

  2025cites this paper
• Genome-Wide Association Integrating a Transcriptomic Meta-Analysis Suggests That Genes Related to Fat Deposition and Muscle Development Are Closely Associated with Growth in Huaxi Cattle

  2025cites this paper
• PABPN1 loss-of-function causes APA-shift in oculopharyngeal muscular dystrophy

  2024cites this paper
• PABPN1 loss-of-function in oculopharyngeal muscular dystrophy primarily impacts APA-shift in muscle transcripts

  2023cites this paper
• Proximity interaction analysis of the Plasmodium falciparum putative ubiquitin ligase PfRNF1 reveals a role in RNA regulation

  2023influential citation
• Pyruvate dehydrogenase B regulates myogenic differentiation via the FoxP1–Arih2 axis

  2022cites this paper
• Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy

  2022cites this paper
• A Ubiquitin-Proteasome Gene Signature for Predicting Prognosis in Patients With Lung Adenocarcinoma

  2022cites this paper
• On the function and relevance of alternative 3′‐UTRs in gene expression regulation

  2021cites this paper
• RBR E3 ubiquitin ligases in tumorigenesis.

  2020cites this paper
• Age-Associated Salivary MicroRNA Biomarkers for Oculopharyngeal Muscular Dystrophy

  2020influential citation
• Arih2 gene influences immune response and tissue development in chicken

  2019cites this paper
• Deacetylation Inhibition Reverses PABPN1-Dependent Muscle Wasting

  2019cites this paper
• Data and -omics-driven approaches to understand the heat stress response: the development of scalable tools and methods to drive hypothesis generation

  2018cites this paper
• Making sense of antisense oligonucleotides: A narrative review

  2018cites this paper
• Interaction profiling of RNA-binding ubiquitin ligases reveals a link between posttranscriptional regulation and the ubiquitin system

  2017cites this paper
• Regulation of Isoform Expression by Blocking Polyadenylation Signal Sequences with Morpholinos.

  2017cites this paper
• Proteasomal activity‐based probes mark protein homeostasis in muscles

  2017cites this paper
• Dysfunctional transcripts are formed by alternative polyadenylation in OPMD

  2017cites this paper
• ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages

  2017cites this paper
• Développement d'une stratégie thérapeutique pour la dystrophie facio-scapulo-humérale.

  2017cites this paper
• This information is current as in Macrophages Regulates NLRP 3 Inflammasome Activation ARIH 2 Ubiquitinates NLRP 3 and Negatively

  2017cites this paper
• Les rôles de PABPN1 dans la dystrophie musculaire oculopharyngée

  2016influential citation
• Polyalanine expansions drive a shift into -helical clusters without amyloid fibril formation.

  2016cites this paper
• Antisense targeting of 3' end elements involved in DUX4 mRNA processing is an efficient therapeutic strategy for facioscapulohumeral dystrophy: a new gene-silencing approach.

  2016cites this paper
• Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing

  2016cites this paper
• An update on RNA-targeting therapies for neuromuscular disorders.

  2015cites this paper
• Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation

  2015cites this paper
• Mechanisms controlling mRNA processing and translation: decoding the regulatory layers defining gene expression through RNA sequencing

  2015cites this paper
• Mitochondrial Dysfunction Reveals the Role of mRNA Poly(A) Tail Regulation in Oculopharyngeal Muscular Dystrophy Pathogenesis

  2015cites this paper
• Oculopharyngeal Muscular Dystrophy as a Paradigm for Muscle Aging

  2014cites this paper
• Ageing and muscular dystrophy differentially affect murine pharyngeal muscles in a region‐dependent manner

  2014cites this paper