Novel thiazole derivatives as inhibitors of superoxide production by human neutrophils: synthesis and structure-activity relationships.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Journal of Medicinal Chemistry

• Publication date

  1995-01-20

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/JM00002A017PMID 7830278
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Superoxide inhibition following different stimuli of respiratory burst and metabolism of aminosalicylates in neutrophils

  2005cited by this paper
• Orally active, nonpeptide vasopressin V1 antagonists. A novel series of 1-(1-substituted 4-piperidyl)-3,4-dihdyro-2(1H)-quinolinone.

  1993cited by this paper
• Multiple actions of the leukotriene B4 receptor antagonist SC-41930.

  1992cited by this paper
• Novel positive inotropic agents: synthesis and biological activities of 6-(3-amino-2-hydroxypropoxy)-2(1H)-quinolinone derivatives.

  1992cited by this paper
• Scavenger and antioxidant properties of ten synthetic flavones.

  1992cited by this paper
• Expression of a hybrid Cu/Zn-type superoxide dismutase which has high affinity for heparin-like proteoglycans on vascular endothelial cells.

  1991cited by this paper
• Role of granulocytes in endothelial injury in coronary heart disease in humans.

  1991cited by this paper
• Effects of superoxide dismutase on reperfusion arrhythmias and left ventricular function in patients undergoing thrombolysis for anterior wall acute myocardial infarction.

  1991cited by this paper
• Inhibitors of the leukocyte superoxide generating oxidase: mechanisms of action and methods for their elucidation.

  1990cited by this paper
• Tissue destruction by neutrophils.

  1989cited by this paper
• Synthesis of a superoxide dismutase derivative that circulates bound to albumin and accumulates in tissues whose pH is decreased.

  1989cited by this paper
• Phase II trial of copper zinc superoxide dismutase (CuZnSOD) in treatment of Crohn's disease.

  1989cited by this paper
• Current concepts: immunology. Neutrophils in human diseases.

  1987cited by this paper
• Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. 2-(4-Chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propi oni c acid and related compounds.

  1985cited by this paper
• Synergism between A23187 and 1-oleoyl-2-acetyl-glycerol in superoxide production by human neutrophils.

  1984cited by this paper
• Measurement of O2- production by human neutrophils. The preparation and assay of NADPH oxidase-containing particles from human neutrophils.

  1984cited by this paper
• Anti‐inflammatory and pharmacokinetic properties of superoxide dismutase derivatized with polyethylene glycol via active esters

  1983cited by this paper
• Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).

  1969cited by this paper

• Oxalyl Chloride: A Versatile Reagent in Organic Transformations

  2019cites this paper
• Transformation of aromatic bromides into aromatic nitriles with n-BuLi, pivalonitrile, and iodine under metal cyanide-free conditions

  2019cites this paper
• Facile Synthesis of Nitriles and Amides from Aldehyde over Heterogeneous Reusable Copper Fluorapatite (CuFAP) Catalyst under Neat Reaction Condition

  2017cites this paper
• PDE4 Inhibition and Inflammatory Bowel Disease: A Novel Therapeutic Avenue

  2017cites this paper
• Direct Synthesis of Nitriles from Aldehydes and Hydroxylamine Hydrochloride Catalyzed by a HAP@AEPH2-SO3H Nanocatalyst

  2017cites this paper
• Facile Synthesis of Nitriles and Amides from Aldehyde over Heterogeneous Reusable Copper Fluorapatite ( CuFAP ) Catalyst under Neat Reaction Condition

  2017cites this paper
• One‐Pot Preparation of C1‐Homologated Aliphatic Nitriles from Aldehydes through a Wittig Reaction under Metal‐Cyanide‐Free Conditions

  2017cites this paper
• One-pot conversion of aldehydes to nitriles mediated by TiCl4

  2017cites this paper
• 2-Cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride alters lipopolysaccharide-induced proinflammatory cytokines and neuronal morphology in mouse fetal brain.

  2016cites this paper
• Synthesis of Nitriles from Aldehydes with Trimethylphenylammonium Tribromide and Ammonium Acetate

  2016cites this paper
• Preparation of aromatic nitriles via direct oxidative conversion of benzyl alcohols, aldehydes and amines with pentylpyridinium tribromide in aqueous NH4OAc

  2015cites this paper
• Facile One‐Pot Transformation of Arenes into Aromatic Nitriles under Metal‐Cyanide‐Free Conditions

  2015cites this paper
• Chemistry of 3-(2-Haloacyl)indoles

  2015cites this paper
• A highly efficient electrochemical route for the conversion of aldehydes to nitriles

  2015cites this paper
• Anti-inflammatory mechanisms of N-adamantyl-4-methylthiazol-2-amine in lipopolysaccharide-stimulated BV-2 microglial cells.

  2014cites this paper
• 2-Cyclopropylimino-3-Methyl-1,3-Thiazoline Hydrochloride Inhibits Microglial Activation by Suppression of Nuclear Factor-Kappa B and Mitogen-Activated Protein Kinase Signaling

  2014cites this paper
• Facile One‐Pot Transformation of Phenols into o‐Cyanophenols

  2014cites this paper
• Highly active recyclable heterogeneous nanonickel ferrite catalyst for cyanation of aryl and heteroaryl halides

  2014cites this paper
• Synthesis and MRSA PK inhibitory activity of thiazole containing deoxytopsentin analogues

  2014cites this paper
• One‐Pot Transformation of Carboxylic Acids into Nitriles

  2013cites this paper
• Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry

  2013cites this paper
• Trisubstituted thiophene analogues of 1-thiazolyl-2-pyrazoline, super oxidase inhibitors and free radical scavengers.

  2013cites this paper
• Thiazoles and thiazolidinones as antioxidants.

  2013cites this paper
• Practical one-pot conversion of aryl bromides and β-bromostyrenes into aromatic nitriles and cinnamonitriles

  2013cites this paper
• Ligand-free nano copper oxide catalyzed cyanation of aryl halides and sequential one-pot synthesis of 5-substituted-1H-tetrazoles

  2013cites this paper
• 2-Amino-1,3-thiazoles Suppressed Lipopolysaccharide-Induced IL-β and TNF-α

  2013cites this paper
• Direct Synthesis of Nitriles from Alcohols or Aldehydes Using H5IO6/KI in Aqueous Ammonia

  2013cites this paper
• Combustion-derived CuO nanoparticles: An effective and environmentally benign catalyst in the synthesis of aromatic nitriles from aromatic aldehydes

  2013cites this paper
• Tetomilast attenuates elastase-induced pulmonary emphysema through inhibition of oxidative stress in rabbits.

  2012cites this paper
• Amberlite IR-120H: An improved reusable solid phase catalyst for the synthesis of nitriles under solvent free microwave irradiation

  2012cites this paper
• Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes.

  2012cites this paper
• Biological therapy for ulcerative colitis: what is after anti-TNF.

  2011cites this paper
• Studies of some monocyclic and bicyclic arylacetonitriles

  2011cites this paper
• Structural and computational studies of 2,5-diarylpenta-2,4-dienenitriles

  2011cites this paper
• Synthesis of functionalized diaryl alkanes from azines using Lewis acidic ionic liquids

  2011cites this paper
• Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.

  2010cites this paper
• Palladium-catalyzed cyanation reaction of aryl halides using K4[Fe(CN)6] as non-toxic source of cyanide under microwave irradiation

  2010cites this paper
• Phosphodiesterase 4 inhibitors in inflammatory bowel disease: a comprehensive review.

  2010cites this paper
• Efficient and High-Yielding Protocol for the Synthesis of Nitriles from Aldehydes

  2010cites this paper
• Synthesis and antimicrobial activity of tetrazolo[1,5-a]quinoline-4-carbonitrile derivatives

  2010cites this paper
• Zinc Chloride–Catalyzed Expeditious Route to Nitriles

  2010cites this paper
• Environment friendly protocol for the synthesis of nitriles from aldehydes

  2010cites this paper
• Consecutive reaction of bis[2,2,2-trifluoroethyl]phosphite. One pot synthesis of substituted 3-cyano-－β,γ-unsaturated nitriles with exclusive or predominant E-selectivity

  2010cites this paper
• Microwave Assisted, Solvent Free One Pot Synthesis of Nitriles from Aryl Aldehydes on Melamin Formaldehyde as Solid Support.

  2010cites this paper
• Leishmanicidal activity of new megazol derivatives.

  2009cites this paper
• A Facile One-Pot Conversion of Aldehydes into Nitriles

  2009cites this paper
• ABCD of the phosphodiesterase family: interaction and differential activity in COPD

  2008cites this paper
• Controlled conversion of phenylacetic acids to phenylacetonitriles or benzonitriles using bis(2-methoxyethyl)aminosulfur trifluoride

  2008cites this paper
• Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL‐10‐deficient mice

  2008cites this paper
• Synthesis of 2-Dithioacetalmethylene-3-oxobutyronitrile from 2-Dithioacetalmethylene-3-oxobutyramide

  2007cites this paper
• A randomized, placebo-controlled, phase II study of tetomilast in active ulcerative colitis.

  2007cites this paper
• Chronic obstructive pulmonary disease: histopathology, inflammation and potential therapies.

  2007cites this paper
• Phosphodiesterase 4 inhibitors and inflammatory bowel disease: emerging therapies in inflammatory bowel disease

  2007cites this paper
• 4-Hydroxy-3,5-dimethoxybenzonitrile at 125 K

  2007cites this paper
• A Novel and Efficient Synthesis of Nitriles from Aldehydes under Solvent-free Microwave Irradiation Conditions

  2007cites this paper
• Direct Synthesis of Aromatic Nitriles from Aldehydes Using Hydroxylamine and Oxalyl Chloride

  2007cites this paper
• Efficient one-pot synthesis of cyanoferrocene from ferrocenecarboxaldehyde using NH2OH · HCl/KI/ZnO/CH3CN system

  2007cites this paper
• Optimized Synthesis of AMPA Receptor Antagonist ZK 187638 and Neurobehavioral Activity in a Mouse Model of Neuronal Ceroid Lipofuscinosis

  2006cites this paper
• Convenient syntheses of N-methylthioamides: A migration of the H2S molecule in the thioamide-nitrile system

  2006cites this paper
• Medicinal Chemistry of PDE4 Inhibitors

  2006cites this paper
• Microwave-Assisted Efficient One-Pot Synthesis of Nitriles From Aldehydes in the Presence of P2O5/SiO2 in Solvent-Free Media

  2005cites this paper
• An efficient and convenient KF/Al2O3 mediated synthesis of nitriles from aldehydes

  2005cites this paper
• Thionoamides and Their Se and Te Analogs

  2005cites this paper
• One‐Pot Synthesis of Trifluoromethylated 4‐Cyanoalka‐1,4‐dienes with Predominant Z‐Selectivity

  2005cites this paper
• Effective synthesis of some indole nitriles from the related carbaldoximes

  2005cites this paper
• Basic Al 2 O 3 /PCl 5 as an Efficient Reagent for the Direct Synthesis of Nitriles from Aldehydes under Solvent-Free Conditions

  2005cites this paper
• Phosphodiesterase-4 as a potential drug target

  2005cites this paper
• SYNTHESIS OF 2-(1,3-DIARYPYRAZOL-5-YLAMINO)-4(3-OXO-2H-1,4-BENZOXAATHIAZIN-6-YL)-THIAZOLES

  2005cites this paper
• Inhibitors of PDE4: a review of recent patent literature

  2005cites this paper
• Efficient Transformation of Aldoximes to Nitriles Using 2‐Chloro‐1‐methylpyridinium Iodide Under Mild Conditions

  2004cites this paper
• Effects of OPC-6535 on lipopolysaccharide-induced acute liver injury in the rat: involvement of superoxide and tumor necrosis factor-alpha from hepatic macrophages.

  2003cites this paper
• Microwave-promoted Pd-catalyzed cyanation of aryl triflates: a fast and versatile access to 3-cyano-3-desoxy-10-ketomorphinans.

  2003cites this paper
• A practical synthesis of 3,4-diethoxybenzthioamide based on Friedel-Crafts reaction with potassium thiocyanate in methanesulfonic acid.

  2002cites this paper
• “One‐pot” synthesis of (Z)‐2‐aryl‐1‐(2‐cyanoethyl)ethenylphosphonates via hexamethylphosphoramide‐promoted sequential transformation

  2002cites this paper
• A novel synthesis of 2-arylpyrrolo[1,2-a]pyrimid-7-ones and their structure-activity relationships as potent GnRH receptor antagonists.

  2002cites this paper
• OPC-compounds prevent oxidant-induced carbonylation and depolymerization of the F-actin cytoskeleton and intestinal barrier hyperpermeability.

  2001cites this paper
• Syntheses and cytotoxicity evaluation of bis(indolyl)thiazole, bis(indolyl)pyrazinone and bis(indolyl)pyrazine: analogues of cytotoxic marine bis(indole) alkaloid.

  2000cites this paper
• Fast microwave-assisted preparation of aryl and vinyl nitriles and the corresponding tetrazoles from organo-halides

  2000cites this paper
• Protective effect of OPC-6535, a superoxide anion production inhibitor, on liver grafts subjected to warm ischemia during porcine liver transplantation.

  2000cites this paper
• TrocCl Mediated Efficient Synthesis of Nitriles from Primary Amides

  2000cites this paper
• Indium-Mediated Facile Dehydration and Beckmann Rearrangement of Oximes

  2000cites this paper
• A New, Mild, Neutral and Inexpensive Method for Conversion of Aldoximes to Nitriles Using Anhydrous Ferric Sulphate

  2000cites this paper
• One-pot synthesis of nitriles from aldehydes under microwave irradiation: influence of the medium and mode of microwave irradiation on product formation

  1999cites this paper
• Syntheses and biological activities of bis(3-indolyl)thiazoles, analogues of marine bis(indole)alkaloid nortopsentins.

  1999cites this paper
• Role of superoxide anion in the pathogenesis of cytokine-induced myocardial dysfunction in dogs in vivo.

  1999cites this paper
• A new one pot method for the conversion of aldehydes into nitriles using hydroxyamine and phthalic anhydride

  1998cites this paper
• OPC-6535, a superoxide anion production inhibitor, attenuates acute lung injury.

  1997cites this paper
• Bioisosterism: A Rational Approach in Drug Design.

  1996cites this paper
• The preparation and wittig condensations of C-4 thiazole phosphonium methylides

  1996cites this paper