Reduction of fluoromisonidazole, a new imaging agent for hypoxia.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Biochemical Pharmacology

• Publication date

  1991-11-27

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0006-2952(91)90245-ZPMID 1764122
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fundamentals of Biostatistics.

  1992cited by this paper
• Characteristics of the binding of labeled fluoromisonidazole in cells in vitro.

  1990cited by this paper
• Radiolabelled fluoromisonidazole as an imaging agent for tumor hypoxia.

  1989cited by this paper
• Enhanced binding of the hypoxic cell marker [3H]fluoromisonidazole in ischemic myocardium.

  1989cited by this paper
• Oxygen dependence of binding of misonidazole to rodent and human tumors in vitro.

  1987cited by this paper
• Synthesis and characterization of congeners of misonidazole for imaging hypoxia.

  1987cited by this paper
• Biochemistry of misonidazole reduction by NADPH-cytochrome c (P-450) reductase.

  1986cited by this paper
• Pharmacology and toxicology of sensitizers: mechanism studies.

  1984cited by this paper
• Nuclear oncology 1984.

  1984cited by this paper
• Metabolic blocker-induced cell damage in rat cardiac tissue. Comparison of three models currently used: the isolated perfused heart, heart cell cultures and isolated myocytes.

  1984cited by this paper
• Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells.

  1983cited by this paper
• Bis(alkylamino)anthracenedione antineoplastic agent metabolic activation by NADPH-cytochrome P-450 reductase and NADH dehydrogenase: diminished activity relative to anthracyclines.

  1983cited by this paper
• Nitroimidazoles as anaerobic electron acceptors for xanthine oxidase.

  1982cited by this paper
• Reduction of misonidazole and its derivatives by xanthine oxidase.

  1981cited by this paper
• The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes.

  1980cited by this paper
• An experimental and analytical study of oxygen depletion in stirred cell suspensions.

  1980cited by this paper
• Structure-function dependence and allopurinol inhibition of radiosensitizer/nitroreductase interaction: approaches to improving therapeutic ratios.

  1980cited by this paper
• Binding to cellular macromolecules as a possible mechanism for the cytotoxicity of misonidazole.

  1980cited by this paper
• Gallium-67 citrate imaging in Hodgkin's disease: final report of cooperative group.

  1977cited by this paper
• Hypoxic sensitizers: radiobiological studies at the cellular level.

  1975cited by this paper
• Nitroreduction of 5-nitrofuran derivatives by rat liver xanthine oxidase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase.

  1974cited by this paper
• Radiobiology for the radiologist

  1973cited by this paper
• Reduction of niridazole by rat liver santhine oxidase.

  1971cited by this paper
• Enzymatic reduction of niridazole by rat liver microsomes.

  1971cited by this paper
• On the mechanism of inactivation of xanthine oxidase by allopurinol and other pyrazolo[3,4-d]pyrimidines.

  1970cited by this paper
• [120] DPNH cytochrome c reductase (animal)

  1955cited by this paper
• Effect of adenine nucleotides on reactions involving triphosphopyridine nucleotide.

  1955cited by this paper

• [18F]FMISO PET in metastatic neuroendocrine tumours: a pilot study

  2025cites this paper
• Novel Targets, Novel Treatments: The Changing Landscape of Non-Small Cell Lung Cancer

  2023cites this paper
• Timing of hypoxia PET/CT imaging after 18F-fluoromisonidazole injection in non-small cell lung cancer patients

  2022cites this paper
• Targeting Tumor Hypoxia

  2020cites this paper
• Development of a hypoxic nanocomposite containing high-Z element as 5-fluorouracil carrier activated self-amplified chemoradiotherapy co-enhancement

  2019cites this paper
• The role of new PET tracers for lung cancer

  2019cites this paper
• A Novel PET Probe “[18F]DiFA” Accumulates in Hypoxic Region via Glutathione Conjugation Following Reductive Metabolism

  2018cites this paper
• The integrated stress response mediates type I interferon driven necrosis in Mycobacterium tuberculosis granulomas

  2018cites this paper
• Développement de plateformes moléculaires silylées supportées pour une fluoration facilitée de biomolécules : études de réactivité et applications en imagerie par tomographie d'émission de positons (TEP)

  2018cites this paper
• Multimodality Preclinical Imaging in Inflammatory Diseases

  2018cites this paper
• Hypoxia in Head and Neck Cancer

  2017cites this paper
• FMISO accumulation in tumor is dependent on glutathione conjugation capacity in addition to hypoxic state

  2017cites this paper
• Molecular mechanisms of hypoxia in cancer

  2017cites this paper
• eview he role of new PET tracers for lung cancer

  2016cites this paper
• The role of new PET tracers for lung cancer.

  2016cites this paper
• Hypoxia Image Guided Radiation Therapy: Current Status and Major Challenges

  2016cites this paper
• Hypoxia and tissue destruction in pulmonary TB

  2016cites this paper
• In Vivo Chemiluminescent Imaging Agents for Nitroreductase and Tissue Oxygenation.

  2016cites this paper
• Hypoxia and tissue destruction in pulmonary tuberculosis

  2016cites this paper
• Quantifying hypoxia in human cancers using static PET imaging

  2016cites this paper
• Pharmacokinetic Analysis of 64Cu-ATSM Dynamic PET in Human Xenograft Tumors in Mice

  2015cites this paper
• Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging

  2015cites this paper
• Molecular imaging of hypoxia in non-small-cell lung cancer

  2015cites this paper
• Automated synthesis and PET evaluation of both enantiomers of [¹⁸F]FMISO.

  2015cites this paper
• Synthetic and biological investigations into hypoxia-activated anti-tumour codrugs

  2015cites this paper
• The accumulation mechanism of the hypoxia imaging probe “FMISO” by imaging mass spectrometry: possible involvement of low-molecular metabolites

  2015cites this paper
• Current Clinical Imaging of Hypoxia with PET and Future Perspectives

  2014cites this paper
• PET Molecular Imaging of Hypoxia in Ischemic Stroke: An Update.

  2014cites this paper
• A fluorous and click approach for screening potential PET probes: Evaluation of potential hypoxia biomarkers.

  2012cites this paper
• Imaging of hypoxia using PET and MRI.

  2012cites this paper
• Positron emission tomography/computed tomography imaging of residual skull base chordoma before radiotherapy using fluoromisonidazole and fluorodeoxyglucose: potential consequences for dose painting.

  2012cites this paper
• Nitroimidazole radiopharmaceuticals in bioimaging: part I: synthesis and imaging applications.

  2011cites this paper
• Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [18F]FMISO as hypoxia-selective tracer for PET.

  2010cites this paper
• Radiosynthesis of [(131)I]IAZGP via nucleophilic substitution and its biological evaluation as a hypoxia marker - is specific activity a factor influencing hypoxia-mapping ability of a hypoxia marker?

  2009cites this paper
• Molecular Imaging of Hypoxia

  2008cites this paper
• Novel imaging approaches to head and neck cancer.

  2008cites this paper
• Positron Emission Tomography Imaging of Blood Flow and Hypoxia in Tumors

  2007cites this paper
• PET-based biological imaging for radiation therapy treatment planning.

  2006cites this paper
• NanoPET imaging of [18F]fluoromisonidazole uptake in experimental mouse tumours

  2006cites this paper
• Hypoxia imaging-directed radiation treatment planning

  2006cites this paper
• PET Imaging for Tumor Hypoxia: Characterizing the Tumor and Guiding Treatment

  2006cites this paper
• Imaging hypoxia and angiogenesis in tumors.

  2005cites this paper
• PET radiopharmaceuticals for metabolic imaging in oncology

  2004cites this paper
• pO2 Polarography Versus Positron Emission Tomography ([18F] Fluoromisonidazole, [18F]-2-Fluoro-2’-Deoxyglucose)

  2004cites this paper
• Synthesis and evaluation of 4-bromo-1-(3-[18F]fluoropropyl)-2-nitroimidazole with a low energy LUMO orbital designed as brain hypoxia-targeting imaging agent.

  2002cites this paper
• Sanazole as substrate of xanthine oxidase and microsomal NADPH/cytochrome P450 reductase.

  2001cites this paper
• Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix.

  2001cites this paper
• Misonidazole Labeling as a Marker of Cellular Hypoxia

  2000cites this paper
• Role of NADPH:cytochrome P450 reductase in the hypoxic accumulation and metabolism of BRU59-21, a technetium-99m-nitroimidazole for imaging tumor hypoxia.

  2000cites this paper
• PET and drug research and development.

  1999cites this paper
• Synthesis and characterization of lipophilic 1-[18F]fluoroalkyl-2-nitroimidazoles for imaging hypoxia.

  1999cites this paper
• Generation of sanazole nitro radicals by xanthine oxidase.

  1998cites this paper
• Bioreductive metabolism of the novel fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitroimidazolyl) acetamide (SR-4554).

  1997cites this paper
• Effect of acute and chronic intermittent hypoxia on DNA topoisomerase II alpha expression and mitomycin C-induced DNA damage and cytotoxicity in human colon cancer cells.

  1996cites this paper
• Effect of acute and chronic intermittent hypoxia on DNA topoisomerase IIα expression and mitomycin C-Induced DNA damage and cytotoxicity in human colon cancer cells

  1996cites this paper
• Nitroimidazoles and imaging hypoxia

  1995cites this paper
• Mechanism of the selective hypoxic cytotoxicity of 1-methyl-2-nitroimidazole.

  1994cites this paper
• TcO(PnA.O-1-(2-nitroimidazole)) [BMS-181321], a new technetium-containing nitroimidazole complex for imaging hypoxia: synthesis, characterization, and xanthine oxidase-catalyzed reduction.

  1994cites this paper
• Synthesis, characterization, and in vitro evaluation of nitroimidazole--BATO complexes: new technetium compounds designed for imaging hypoxic tissue.

  1993cites this paper
• PET in drug research and development

  1992cites this paper