Cilostazol attenuates hepatic stellate cell activation and protects mice against carbon tetrachloride‐induced liver fibrosis

S. Saito,K. Hata,K. Iwaisako,Atsuko Yanagida,M. Takeiri,Hirokazu Tanaka,S. Kageyama,H. Hirao,K. Ikeda,M. Asagiri,S. Uemoto

Published 2014 in Hepatology Research

ABSTRACT

Liver fibrosis is a common pathway leading to cirrhosis. Cilostazol, a clinically available oral phosphodiesterase‐3 inhibitor, has been shown to have antifibrotic potential in experimental non‐alcoholic fatty liver disease. However, the detailed mechanisms of the antifibrotic effect and its efficacy in a different experimental model remain elusive.

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