Dendritic action potentials activated by NMDA receptor-mediated EPSPs in CA1 hippocampal pyramidal cells.

Intradendritic recordings were obtained in rat CA1 hippocampal pyramidal cells. Repetitive stimulation produced substantial short-term potentiation of the dendritic excitatory postsynaptic potential (EPSP) which was partly attributable to activation of n-methyl-D-aspartate receptors. Accompanying the potentiated synaptic response were Na(+)-mediated spikes which appeared to originate at multiple sites in the dendritic arbor. These discrete dendritic action potentials are rarely distinguishable in somatic recordings, but may contribute to the subthreshold response at the pyramidal cell body. In addition, dendritic spikes may interact with other voltage-dependent dendritic conductances.

• Publication year

  1990

• Venue

  Brain Research

• Publication date

  1990-08-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0006-8993(90)90714-MPMID 1981329
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Elevated extracellular potassium concentration enhances synaptic activation of N-methyl-D-aspartate receptors in hippocampus.

  1990cited by this paper
• Activity-evoked increases in extracellular potassium modulate presynaptic excitability in the CA1 region of the hippocampus.

  1987cited by this paper
• The physiology of excitatory amino acids in the vertebrate central nervous system.

  1987cited by this paper
• Postsynaptic membrane shifts during frequency potentiation of the hippocampal EPSP.

  1987cited by this paper
• Synaptic control of excitability in isolated dendrites of hippocampal neurons

  1984cited by this paper
• Control of the repetitive discharge of rat CA 1 pyramidal neurones in vitro.

  1984cited by this paper
• Electrophysiology of isolated hippocampal pyramidal dendrites

  1982cited by this paper
• Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices.

  1980cited by this paper
• Changes in excitatory and inhibitory synaptic potentials leading to epileptogenic activity.

  1980cited by this paper
• Intradendritic recordings from hippocampal neurons.

  1979cited by this paper
• Further characteristics of hippocampal CA1 cells in vitro.

  1977cited by this paper
• Electrophysiological properties of dendrites and somata in alligator Purkinje cells.

  1971cited by this paper
• ELECTROPHYSIOLOGY OF HIPPOCAMPAL NEURONS: IV. FAST PREPOTENTIALS.

  1961cited by this paper

• Interstitial ions: A key regulator of state-dependent neural activity?

  2020cites this paper
• mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways

  2017cites this paper
• An Augmented Two-Layer Model Captures Nonlinear Analog Spatial Integration Effects in Pyramidal Neuron Dendrites

  2014cites this paper
• Dendritic integration in hippocampal dentate gyrus granule cells

  2011cites this paper
• Patch‐Clamp Recording from Neuronal Dendrites

  2004cites this paper
• Interactions of synaptic and intrinsic electroresponsiveness determine corticothalamic activation dynamics

  2001cites this paper
• Impact of active dendrites and structural plasticity on the memory capacity of neural tissue.

  2001cites this paper
• Stochastic resonance improves signal detection in hippocampal CA1 neurons.

  2000cites this paper
• Resonantlike Synchronization and Bursting in a Model of Pulse-Coupled Neurons with Active Dendrites

  1999cites this paper
• Functional Implications of Active Currents in the Dendrites of Pyramidal Neurons

  1999cites this paper
• Synaptically evoked dendritic action potentials in rat neocortical pyramidal neurons.

  1998cites this paper
• Dendritic sodium spikes are variable triggers of axonal action potentials in hippocampal CA1 pyramidal neurons.

  1998cites this paper
• Postsynaptic Complex Spike Bursting Enables the Induction of LTP by Theta Frequency Synaptic Stimulation

  1998cites this paper
• Interneurons of the hippocampus

  1998cites this paper
• Novel expression mechanism for synaptic potentiation: alignment of presynaptic release site and postsynaptic receptor.

  1997cites this paper
• Local and propagated dendritic action potentials evoked by glutamate iontophoresis on rat neocortical pyramidal neurons.

  1997cites this paper
• Equivalence of amplified current flowing from dendrite to soma measured by alteration of repetitive firing and by voltage clamp in layer 5 pyramidal neurons.

  1996cites this paper
• Differential back-invasion of a single complex dendrite of an abducens motoneuron by N-methyl-D-aspartate-induced oscillations: a simulation study.

  1996cites this paper
• Synaptic interaction of hippocampal gabaergic neurones

  1996cites this paper
• Functional geometry of amino acid sensitive membrane of layer V neurons in the guinea-pig neocortex in vitro.

  1995cites this paper
• Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites.

  1995cites this paper
• Action in the Dendrites: A Revisitation of Dendritic Action Potentials

  1995cites this paper
• Factors affecting paired-pulse facilitation in hippocampal CA1 neurons in vitro.

  1994cites this paper
• Information Processing in Dendritic Trees

  1994cites this paper
• NMDA receptors have a dominant role in population spike-paired pulse facilitation in the dentate gyrus of urethane-anesthetized rats.

  1993cites this paper
• The mechanism of tonic inhibition of crayfish escape behavior: distal inhibition and its functional significance

  1993cites this paper
• Ionic flux contributions to neocortical slow waves and nucleus basalis- mediated activation: whole-cell recordings in vivo

  1993cites this paper
• Synaptic integration in an excitable dendritic tree.

  1993cites this paper
• Regenerative activity in apical dendrites of pyramidal cells in neocortex.

  1993cites this paper
• Blockade of antidromic invasion of CA1 pyramidal cells during synaptic activation of NMDA receptors.

  1993cites this paper
• Characterization in vivo of the NMDA receptor‐mediated component of dentate granule cell population synaptic responses to perforant path input

  1992cites this paper
• A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons.

  1992cites this paper
• Integration of Synchronous Input in Dentate Granule Cells ... Integration of Synchronous Input in Dentate Granule Cells ..... Clustered Input Is Integrated Linearly with a Gain

  year unknowncites this paper