Nitrous oxide persistently alleviates pain hypersensitivity in neuropathic rats: A dose-dependent effect

Currently, for patients experiencing neuropathic pain, there are no common analgesic drugs that produce meaningful relief. Although nitrous oxide (N2O) is a weak analgesic and there are concerns regarding its deleterious effects, reviews of current controversies have concluded that it should remain an option in anesthesia. The authors of this study had two objectives: to evaluate the lowest N2O concentration and the shortest time of N2O postinjury exposure that would produce persistent relief of neuropathic pain; and to compare the effects of N2O with gabapentin.

• Publication year

  2015

• Venue

  Pain Research and Management

• Publication date

  2015-09-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1155/2015/809059PMID 26371891PMCID 4676501
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of valproic Acid on axonal regeneration and recovery of motor function after peripheral nerve injury in the rat.

  2014cited by this paper
• Nitrous oxide and perioperative outcomes

  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
• The neuropathic component in persistent postsurgical pain: A systematic literature review

  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• Prevention of chronic postoperative pain: cellular, molecular, and clinical insights for mechanism-based treatment approaches.

  2013cited by this paper
• Management of painful neuropathies.

  2013cited by this paper
• Chronic pain after childbirth.

  2013cited by this paper
• Chronic postsurgical pain after nitrous oxide anesthesia

  2011influential reference
• Nonselective and NR2B-selective N-methyl-d-aspartic Acid Receptor Antagonists Produce Antinociception and Long-term Relief of Allodynia in Acute and Neuropathic Pain

  2011cited by this paper
• Nitrous Oxide and Long-Term Morbidity and Mortality in the ENIGMA Trial

  2011cited by this paper
• A single nitrous oxide (N2O) exposure leads to persistent alleviation of neuropathic pain in rats.

  2010influential reference
• EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision

  2010cited by this paper
• NMDA receptor antagonists for the treatment of neuropathic pain.

  2010cited by this paper
• Ketamine for the treatment of chronic non-cancer pain

  2010cited by this paper
• Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat.

  2010cited by this paper
• Transition from acute to chronic postsurgical pain: risk factors and protective factors

  2009cited by this paper
• Gabapentin Acts within the Locus Coeruleus to Alleviate Neuropathic Pain

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
• Biologic Effects of Nitrous Oxide: A Mechanistic and Toxicologic Review

  2008cited by this paper
• Use of gabapentin for perioperative pain control -- a meta-analysis.

  2007cited by this paper
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  2007cited by this paper
• Oral Gabapentin Activates Spinal Cholinergic Circuits to Reduce Hypersensitivity after Peripheral Nerve Injury and Interacts Synergistically with Oral Donepezil

  2007cited by this paper
• Advances in understanding the actions of nitrous oxide.

  2007cited by this paper
• Management of painful neuropathies

  2007cited by this paper
• Gabapentin Activates Spinal Noradrenergic Activity in Rats and Humans and Reduces Hypersensitivity after Surgery

  2007cited by this paper
• Mechanisms of Disease: neuropathic pain—a clinical perspective

  2006cited by this paper
• Persistent postsurgical pain: risk factors and prevention.

  2006cited by this paper
• EFNS guidelines on pharmacological treatment of neuropathic pain

  2006cited by this paper
• Recent advances in the development of NR2B subtype-selective NMDA receptor antagonists.

  2006cited by this paper
• Effect of N-methyl-d-aspartate Receptor &egr;1 Subunit Gene Disruption of the Action of General Anesthetic Drugs in Mice

  2005cited by this paper
• Evidence that gabapentin reduces neuropathic pain by inhibiting the spinal release of glutamate

  2005cited by this paper
• NMDA antagonists and neuropathic pain--multiple drug targets and multiple uses.

  2005cited by this paper
• Nitrous Oxide Revisited: Evidence for Potent Antihyperalgesic Properties

  2005cited by this paper
• Role of descending noradrenergic system and spinal α2‐adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse

  2005cited by this paper
• The two-pore-domain K(+) channels TREK-1 and TASK-3 are differentially modulated by copper and zinc.

  2004cited by this paper
• Nitrous oxide (N(2)O) requires the N-methyl-D-aspartate receptor for its action in Caenorhabditis elegans.

  2004cited by this paper
• Prolonged exposure to inhalational anesthetic nitrous oxide kills neurons in adult rat brain.

  2003cited by this paper
• Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin.

  2002cited by this paper
• Can we conquer pain?

  2002cited by this paper
• Neurobiology of nitrous oxide-induced antinociceptive effects

  2002cited by this paper
• The effects of GABAB agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat

  2001cited by this paper
• Differential Effects of General Anesthetics on G Protein–coupled Inwardly Rectifying and Other Potassium Channels

  2001cited by this paper
• Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats.

  1999cited by this paper
• Sister chromatid exchange in human lymphocytes exposed to isoflurane and nitrous oxide in vitro.

  1999cited by this paper
• Clonidine potentiates the neuropathic pain-relieving action of MK-801 while preventing its neurotoxic and hyperactivity side effects.

  1998cited by this paper
• Nitrous oxide minimum alveolar anesthetic concentration in rats is greater than previously reported.

  1994cited by this paper
• A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

  1988cited by this paper
• Local and remote modifications of nociceptive sensitivity during carrageenin‐induced inflammation in the rat

  1987cited by this paper
• The Minimum Alveolar Concentration of Nitrous Oxide in Man

  1982cited by this paper

• Rapid antidepressant potential of nitrous oxide: current state and major questions.

  2025cites this paper
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  2021cites this paper
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