UPLC-QTOF/MS metabolic profiling unveils urinary changes in humans after a whole grain rye versus refined wheat bread intervention.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Molecular Nutrition & Food Research

• Publication date

  2013-03-01

• Fields of study

  Agricultural and Food Sciences, Medicine, Biology

• Identifiers
  DOI 10.1002/mnfr.201200571PMID 23307617
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Public chemical compound databases.

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• Proposed minimum reporting standards for chemical analysis

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  2000cited by this paper
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  1999influential reference
• Rye bread decreases postprandial insulin response but does not alter glucose response in healthy Finnish subjects

  1999cited by this paper

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