Abdominal Obesity Contributes to Neurocognitive Impairment in HIV-Infected Patients With Increased Inflammation and Immune Activation

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Acquired Immune Deficiency Syndromes

• Publication date

  2015-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/QAI.0000000000000458PMID 25469522PMCID PMC4551458
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline

  2014cited by this paper
• Trends in Prevalence and Control of Diabetes in the United States, 19881994 and 19992010

  2014cited by this paper
• Soluble markers of inflammation and coagulation but not T-cell activation predict non-AIDS-defining morbid events during suppressive antiretroviral treatment.

  2014cited by this paper
• Systemic effects of inflammation on health during chronic HIV infection.

  2013cited by this paper
• Applications and Limitations of Inflammatory Biomarkers for Studies on Neurocognitive Impairment in HIV Infection

  2013cited by this paper
• Predictors of symptomatic HIV‐associated neurocognitive disorders in universal health care

  2013cited by this paper
• Relationship between Microbial Translocation and Endothelial Function in HIV Infected Patients

  2012cited by this paper
• Current Epidemiological Approaches to the Metabolic-Cognitive Syndrome

  2012cited by this paper
• Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010.

  2012cited by this paper
• Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial.

  2012cited by this paper
• Arterial inflammation in patients with HIV.

  2012cited by this paper
• Role of obesity, metabolic variables, and diabetes in HIV-associated neurocognitive disorder

  2012cited by this paper
• Defining Neurocognitive Impairment in HIV: Deficit Scores Versus Clinical Ratings

  2012cited by this paper
• Relationship between monocyte/macrophage activation marker soluble CD163 and insulin resistance in obese and normal‐weight subjects

  2012cited by this paper
• Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD)

  2011cited by this paper
• Testosterone threshold levels and lean tissue mass targets needed to enhance skeletal muscle strength and function: the HORMA trial.

  2011cited by this paper
• Neurocognitive Impact of Substance Use in HIV Infection

  2011cited by this paper
• Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging.

  2011cited by this paper
• Metabolic syndrome, mild cognitive impairment, and dementia.

  2011cited by this paper
• Inflammatory links between obesity and metabolic disease.

  2011cited by this paper
• CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice

  2011cited by this paper
• Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia

  2011cited by this paper
• HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy

  2010cited by this paper
• Dyad of CD40/CD40 Ligand Fosters Neuroinflammation at the Blood–Brain Barrier and Is Regulated via JNK Signaling: Implications for HIV-1 Encephalitis

  2010cited by this paper
• Pathogenesis of HIV in the Central Nervous System

  2010cited by this paper
• Metabolic Syndrome, Inflammation, and Nonamnestic Mild Cognitive Impairment in Older Persons: A Population-based Study

  2010cited by this paper
• TLR3 and TLR4 are innate antiviral immune receptors in human microglia: role of IRF3 in modulating antiviral and inflammatory response in the CNS.

  2009cited by this paper
• Attenuation of the cardiovascular and metabolic complications of obesity in CD14 knockout mice.

  2008cited by this paper
• Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects

  2008cited by this paper
• Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients

  2008cited by this paper
• Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

  2008cited by this paper
• Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes.

  2007cited by this paper
• Prevalence of Metabolic Syndrome in HIV-Infected Patients Receiving Highly Active Antiretroviral Therapy Using International Diabetes Foundation and Adult Treatment Panel III Criteria

  2007cited by this paper
• Persistence of Neuropsychologic Deficits Despite Long-TermHighlyActiveAntiretroviralTherapyinPatients With HIV-Related Neurocognitive Impairment: Prevalence and Risk Factors

  2007cited by this paper
• Metabolic Syndrome and Cognitive Disorders: Is the Sum Greater Than Its Parts?

  2007cited by this paper
• Metabolic Syndrome and Cognitive Decline in Elderly Latinos: Findings from the Sacramento Area Latino Study of Aging Study

  2007cited by this paper
• Functional Synergy between CD40 Ligand and HIV-1 Tat Contributes to Inflammation: Implications in HIV Type 1 Dementia1

  2007cited by this paper
• Prevalence of metabolic syndrome in HIV-infected patients receiving highly active antiretroviral therapy using International Diabetes Foundation and Adult Treatment Panel III criteria: associations with insulin resistance, disturbed body fat compartmentalization, elevated C-reactive protein, and [co

  2007cited by this paper
• CD40-CD40 Ligand Interactions Promote Trafficking of CD8+ T Cells into the Brain and Protection against West Nile Virus Encephalitis

  2007cited by this paper
• Microbial translocation is a cause of systemic immune activation in chronic HIV infection

  2006cited by this paper
• Inflammation and insulin resistance.

  2006cited by this paper
• Insulin Resistance Is Associated With Cognition Among HIV-1-Infected Patients: The Hawaii Aging With HIV Cohort

  2006cited by this paper
• Microbial translocation is a cause of systemic immune activation in chronic HIV infection

  2006cited by this paper
• CD40/CD40 Ligand Signaling in Mouse Cerebral Microvasculature After Focal Ischemia/Reperfusion

  2005cited by this paper
• Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement.

  2005cited by this paper
• Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement

  2005cited by this paper
• Toll-Like Receptor 4 on Nonhematopoietic Cells Sustains CNS Inflammation during Endotoxemia, Independent of Systemic Cytokines

  2005cited by this paper
• Predictive Validity of Global Deficit Scores in Detecting Neuropsychological Impairment in HIV Infection

  2004cited by this paper
• Microglia Initiate Central Nervous System Innate and Adaptive Immune Responses through Multiple TLRs1

  2004cited by this paper
• Induction of β-chemokine secretion by human brain microvessel endothelial cells via CD40/CD40L interactions

  2004cited by this paper
• Hyperinsulinemia and risk of Alzheimer disease

  2004cited by this paper
• The metabolic syndrome, inflammation, and risk of cognitive decline.

  2004cited by this paper
• Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

  2003cited by this paper
• CD40 expressed by human brain endothelial cells regulates CD4+ T cell adhesion to endothelium.

  2003cited by this paper
• Body habitus changes related to lipodystrophy.

  2003cited by this paper
• Inflammation and insulin resistance.

  2003cited by this paper
• Role of insulin and insulin receptor in learning and memory.

  2001cited by this paper
• Elevated blood pressure in subjects with lipodystrophy

  2001cited by this paper
• Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Expression of Somatostatin Receptor SST4 in Human Placenta and Absence of Octreotide Effect on Human Placental Growth Hormone Concentration during

  1997cited by this paper
• Increased soluble CD14 serum levels and altered CD14 expression of peripheral blood monocytes in HIV‐infected patients

  1994cited by this paper
• Significance Tests and Goodness of Fit in the Analysis of Covariance Structures

  1980cited by this paper
• For Personal Use. Only Reproduce with Permission the Lancet Publishing Group. Insulin and the Brain Insulin and Neurodegenerative Disease Insulin and Neurodegenerative Disease: Shared and Specific Mechanisms

  year unknowncited by this paper

• Effects of Semaglutide on Cognitive Function in People with HIV: A Randomized Controlled Trial.

  2025cites this paper
• Relationship Between Estimated Drug Distribution of Antiretroviral Therapy and Immune Proteins in Cerebrospinal Fluid During Chronic HIV Suppression

  2025cites this paper
• Integrase strand transfer inhibitors, their impact in adipose tissue and weight gain in people living with HIV - A narrative review.

  2025cites this paper
• Effects of Tesamorelin on Neurocognitive Impairment in Abdominally Obese Persons with HIV.

  2025cites this paper
• Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV

  2024cites this paper
• Additive Effect of Metabolic Syndrome on Brain Atrophy in People Living with HIV–Magnetic Resonance Volumetry Study

  2024cites this paper
• Morbidity and Mortality Risk Among People With Human Immunodeficiency Virus and Central or Visceral Adiposity: A Targeted Literature Review.

  2024cites this paper
• Epigenome-Wide and Methylation Risk Score Analysis of Body Mass Index Among People with HIV

  2024cites this paper
• Obesity Is Associated With Higher Levels of Circulating Cytokines Involved in the Development of Cardiovascular Disease in People Living With HIV

  2024cites this paper
• Correlation between IgG Anti-Toxoplasmosis Gondii Antibodies and Cognitive Function in Human Immunodeficiency Virus-Acquired Immunodeficiency Syndrome (HIV-AIDS) Patients with Cerebral Toxoplasmosis

  2023cites this paper
• Elevated Plasma Protein Carbonyl Concentration Is Associated with More Abnormal White Matter in People with HIV

  2023cites this paper
• The Impact of COVID-19 on People Living with HIV-1 and HIV-1-Associated Neurological Complications

  2023cites this paper
• Effects of different integrase strand transfer inhibitors on body weight in patients with HIV/AIDS: a network meta-analysis

  2022cites this paper
• Learning and memory function in young people with and without perinatal HIV in England

  2022cites this paper
• Obesity in HIV infection: host-pathogen interaction

  2022cites this paper
• Weight Gain and Metabolic Syndrome in Human Immunodeficiency Virus Patients

  2022cites this paper
• Machine learning quantifies accelerated white-matter aging in persons with HIV.

  2022cites this paper
• GlycA is associated with neuropsychological impairment in men with HIV.

  2022cites this paper
• Cerebrospinal fluid immune markers and HIV-associated neurocognitive impairments: A systematic review.

  2021cites this paper
• Central Nervous System Effects of COVID-19 in People with HIV Infection

  2021cites this paper
• Screening for mild cognitive impairment in people with obesity: a systematic review

  2021cites this paper
• Components of metabolic syndrome associated with lower neurocognitive performance in youth with perinatally acquired HIV and youth who are HIV-exposed uninfected

  2021cites this paper
• Long-term weight gain after initiating combination antiretroviral therapy in treatment-naïve Asian people living with human immunodeficiency virus.

  2021cites this paper
• Impact of Efavirenz Mid-dose Plasma Concentration on Long-Term Weight Change Among Virologically Suppressed People Living With HIV

  2021cites this paper
• Bypassing TBI: Metabolic Surgery and the Link between Obesity and Traumatic Brain Injury—a Review

  2020cites this paper
• Baseline 10-year cardiovascular risk scores predict cognitive function in older persons, and particularly women, living with HIV infection.

  2020cites this paper
• Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders.

  2020cites this paper
• Prevention of stroke in people living with HIV.

  2020cites this paper
• Obesity and Weight Gain in Persons with HIV

  2020cites this paper
• Impact of Latent Tuberculosis Infection on Neurocognitive Functioning and Inflammation in HIV-Infected and Uninfected South Indians.

  2020cites this paper
• Weight gain among treatment‐naïve persons with HIV starting integrase inhibitors compared to non‐nucleoside reverse transcriptase inhibitors or protease inhibitors in a large observational cohort in the United States and Canada

  2020cites this paper
• Peripheral immune dysregulation in the ART era of HIV-associated neurocognitive impairments: A systematic review.

  2020cites this paper
• HIV and antiretroviral therapy-related fat alterations

  2020cites this paper
• Association of HIV serostatus and metabolic syndrome with neurobehavioral disturbances

  2020cites this paper
• NO SIGNIFICANT INCREASE IN BODY FAT MASS IN NAIVE HIV-INFECTED PATIENTS STARTING RALTEGRAVIR PLUS TENOFOVIR DISOPROXIL FUMARATE/EMTRICITABINE.

  2020cites this paper
• Insult to Injury-Potential Contribution of Coronavirus Disease-19 to Neuroinflammation and the Development of HIV-Associated Neurocognitive Disorders

  2020cites this paper
• Asymptomatic Malaria Co-infection of HIV-infected Adults in Nigeria: Prevalence of and Impact on Cognition, Mood and Biomarkers of Systemic Inflammation.

  2020cites this paper
• HIV, Vascular Risk Factors, and Cognition in the Combination Antiretroviral Therapy Era: A Systematic Review and Meta-Analysis

  2020cites this paper
• Neuroimaging and Cognitive Evidence for Combined HIV-Alcohol Effects on the Central Nervous System: A Review.

  2020cites this paper
• Neurologic Disease in HIV Infection

  2020cites this paper
• Effects of Different Integrase Inhibitors on Body Weight in Patients with HIV/AIDS: A Network Meta-Analysis

  2020cites this paper
• Weight gain among treatment-naïve persons with HIV starting integrase inhibitors compared to non-nucleoside reverse transcriptase inhibitors or protease inhibitors in a large in

  2020cites this paper
• Neurocognitive Impairment in Well-Controlled HIV-Infected Patients: A Cross-Sectional Study

  2019cites this paper
• Midlife adiposity predicts cognitive decline in the prospective Multicenter AIDS Cohort Study

  2019cites this paper
• Behavioral and Physical Activity Interventions for HAND.

  2019cites this paper
• The current understanding of overlap between characteristics of HIV-associated neurocognitive disorders and Alzheimer’s disease

  2019cites this paper
• Focus groups inform a mobile health intervention to promote adherence to a Mediterranean diet and engagement in physical activity among people living with HIV

  2019cites this paper
• Metabolic Syndrome and Neurocognitive Deficits in HIV Infection

  2019cites this paper
• Cognitive Impairment in Zambians With HIV Infection and Pulmonary Tuberculosis

  2019cites this paper
• Brief Report: Body Mass Index and Cognitive Function Among HIV-1–Infected Individuals in China, India, and Nigeria

  2019cites this paper
• Sex differences in neurocognitive screening among adults living with HIV in China

  2019cites this paper
• Cerebrospinal fluid viral escape in aviremic HIV-infected patients receiving antiretroviral therapy: prevalence, risk factors and neurocognitive effects

  2019cites this paper
• Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients

  2019cites this paper
• Functional deficits and other psychiatric associations with abnormal scores on the Montreal Cognitive Assessment (MoCA) in older HIV-infected patients

  2019cites this paper
• COMT Val158Met Polymorphism, Cardiometabolic Risk, and Nadir CD4 Synergistically Increase Risk for Neurocognitive Impairment in Men Living with HIV.

  2019cites this paper
• Neurocognitive impairment is worse in HIV/HCV-coinfected individuals with liver dysfunction

  2019cites this paper
• Current Challenges and Solutions in Research and Clinical Care of Older Persons Living with HIV: Findings Presented at the 9th International Workshop on HIV and Aging

  2019cites this paper
• Metabolic Risk Factors as Differential Predictors of Profiles of Neurocognitive Impairment Among Older HIV+ and HIV- Adults: An Observational Study.

  2019cites this paper
• Weight gain in antiretroviral therapy-naive HIV-1-infected patients starting a regimen including an integrase strand transfer inhibitor or darunavir/ritonavir

  2019cites this paper
• JAIDS: Journal of Acquired Immune Deficiency Syndromes COMT Val158Met Polymorphism, Cardiometabolic Risk, and Nadir CD4 Synergistically Increase Risk for HIV-associated Neurocognitive Impairment

  2019cites this paper
• Chronic Inflammation in HIV Pathogenesis: Effects on Immune Cells, Organ Systems, and Systemic Consequences

  2018cites this paper
• Metabolic risk factors in young adults infected with HIV since childhood compared with the general population

  2018cites this paper
• Physical Activity Is Associated With Lower Odds of Cognitive Impairment in Women but Not Men Living With Human Immunodeficiency Virus Infection

  2018cites this paper
• Hypertension in HIV-Infected Adults Compared with Similar but Uninfected Adults in China: Body Mass Index-Dependent Effects of Nadir CD4 Count

  2017cites this paper
• Vascular Contributions to Neurocognitive Impairment among Older Persons with HIV

  2017cites this paper
• Brief Report: Weight Gain in Persons With HIV Switched From Efavirenz-Based to Integrase Strand Transfer Inhibitor–Based Regimens

  2017cites this paper
• Elevated Markers of Vascular Remodeling and Arterial Stiffness Are Associated With Neurocognitive Function in Older HIV+ Adults on Suppressive Antiretroviral Therapy

  2017cites this paper
• The Fat of the Matter: Obesity and Visceral Adiposity in Treated HIV Infection

  2017cites this paper
• Metabolic concerns in aging HIV-infected persons: from serum lipid phenotype to fatty liver

  2017cites this paper
• Cardiovascular risk and dyslipidemia among persons living with HIV: a review

  2017cites this paper
• Testing a Computerized Cognitive Training Protocol in Adults Aging With HIV-Associated Neurocognitive Disorders: Randomized Controlled Trial Rationale and Protocol

  2017cites this paper
• Body mass index, inflammatory biomarkers and neurocognitive impairment in HIV-infected persons

  2017cites this paper
• Coagulation imbalance and neurocognitive functioning in older HIV-positive adults on suppressive antiretroviral therapy

  2017cites this paper
• Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status

  2017cites this paper
• Changes in weight and weight distribution across the lifespan among HIV-infected and -uninfected men and women

  2016cites this paper
• The impact of employment on cognition and cognitive reserve: implications across diseases and aging

  2016cites this paper
• Obesity in patients with HIV infection: epidemiology, consequences and treatment options

  2016cites this paper
• Fat Matters: Understanding the Role of Adipose Tissue in Health in HIV Infection

  2016cites this paper
• Lipid and Genetic Predictors of Midlife Cognitive Decline in Treated HIV-1 Infection

  2016cites this paper
• Lipid Profiles and APOE4 Allele Impact Midlife Cognitive Decline in HIV-Infected Men on Antiretroviral Therapy

  2016cites this paper
• Metabolic Syndrome After HIV Acquisition in South African Women

  2016cites this paper
• Increased Intrathecal Immune Activation in Virally Suppressed HIV-1 Infected Patients with Neurocognitive Impairment

  2016cites this paper
• HIV-associated neurocognitive disorders and central nervous system drug penetration: what next?

  2015cites this paper
• Of mice and monkeys: can animal models be utilized to study neurological consequences of pediatric HIV-1 infection?

  2015cites this paper