Gating the Radical Hemoglobin to Macrophages: The Anti-Inflammatory Role of CD163, a Scavenger Receptor

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Antioxidants and Redox Signaling

• Publication date

  2007-05-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/ars.2007.1576PMID 17508920
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification.

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• The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways.

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