Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Molecular Nutrition & Food Research

• Publication date

  2012-11-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1002/mnfr.201200276PMID 23038615PMCID PMC3863390
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The health economics of bladder cancer

  2012cited by this paper
• Metabolism and Tissue Distribution of Sulforaphane in Nrf2 Knockout and Wild-Type Mice

  2011cited by this paper
• Pharmacokinetics and pharmacodynamics of isothiocyanates

  2011cited by this paper
• Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design.

  2011cited by this paper
• Global cancer statistics

  2011cited by this paper
• Inhibition of bladder cancer development by allyl isothiocyanate.

  2010cited by this paper
• Bladder Cancer in 2010: How Far have We Come?

  2010cited by this paper
• Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival

  2010cited by this paper
• Biological Profile of Erucin: A New Promising Anticancer Agent from Cruciferous Vegetables

  2010cited by this paper
• Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues.

  2010cited by this paper
• Are isothiocyanates potential anti-cancer drugs?

  2009cited by this paper
• The origins of bladder cancer

  2008influential reference
• Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry.

  2008cited by this paper
• Current Status of Prognostic Immunohistochemical Markers for Urothelial Bladder Cancer

  2008cited by this paper
• The metabolic fate of purified glucoraphanin in F344 rats.

  2007cited by this paper
• Sulforaphane Retards the Growth of Human PC-3 Xenografts and Inhibits HDAC Activity in Human Subjects

  2007cited by this paper
• Inhibition of urinary bladder carcinogenesis by broccoli sprouts.

  2007cited by this paper
• Association between consumption of cruciferous vegetables and condiments and excretion in urine of isothiocyanate mercapturic acids.

  2006cited by this paper
• The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells

  2006cited by this paper
• Quantitative measurement of sulforaphane, iberin and their mercapturic acid pathway metabolites in human plasma and urine using liquid chromatography-tandem electrospray ionisation mass spectrometry.

  2006cited by this paper
• Effect of sulforaphane on cell growth, G(0)/G(1) phase cell progression and apoptosis in human bladder cancer T24 cells.

  2006cited by this paper
• Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract

  2006cited by this paper
• Urothelial tumorigenesis: a tale of divergent pathways

  2005cited by this paper
• Quantitative determination of intact glucosinolates in broccoli, broccoli sprouts, Brussels sprouts, and cauliflower by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.

  2005influential reference
• Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells

  2005cited by this paper
• Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds.

  2004cited by this paper
• Oligoclonality in bladder cancer: the implication for molecular therapies.

  2004cited by this paper
• Past, Current and Future Trends in Tobacco Use

  2003cited by this paper
• Tomato and soy polyphenols reduce insulin-like growth factor-I-stimulated rat prostate cancer cell proliferation and apoptotic resistance in vitro via inhibition of intracellular signaling pathways involving tyrosine kinase.

  2003cited by this paper
• Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo.

  2003cited by this paper
• Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.

  2003cited by this paper
• Synthesis of isothiocyanate-derived mercapturic acids.

  2003cited by this paper
• Intact glucosinolate analysis in plant extracts by programmed cone voltage electrospray LC/MS: performance and comparison with LC/MS/MS methods.

  2002cited by this paper
• Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation

  2001cited by this paper
• The chemical diversity and distribution of glucosinolates and isothiocyanates among plants.

  2001cited by this paper
• Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.

  2001cited by this paper
• Risk of Bladder Cancer by Geographic Region in a U.S. Cohort of Male Health Professionals

  2001cited by this paper
• Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes.

  2001cited by this paper
• Prospective study of dietary supplements, macronutrients, micronutrients, and risk of bladder cancer in US men.

  2000cited by this paper
• Disposition of Glucosinolates and Sulforaphane in Humans After Ingestion of Steamed and Fresh Broccoli

  2000cited by this paper
• INHIBITION OF CARCINOGENESIS BY ISOTHIOCYANATES*

  2000cited by this paper
• Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohort.

  1999cited by this paper
• Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice.

  1999cited by this paper
• Fluid intake and the risk of bladder cancer in men.

  1999cited by this paper
• Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.

  1997cited by this paper
• Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates.

  1997cited by this paper
• Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms.

  1994cited by this paper
• Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins.

  1994cited by this paper
• Bladder cancer in relation to cigarette smoking.

  1988cited by this paper
• Journal of Translational Medicine the Histone Deacetylase Inhibitor Belinostat (pxd101) Suppresses Bladder Cancer Cell Growth in Vitro and in Vivo

  year unknowncited by this paper

• Sulforaphane in cancer precision medicine: from biosynthetic origins to multiscale mechanisms and clinical translation

  2025cites this paper
• Adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research Cancer Prevention Recommendations and risk of lifestyle-related cancers in the prostate, lung, colorectal, and ovarian cancer screening trial

  2025cites this paper
• Phytochemicals as Chemo-Preventive and Therapeutic Agents Against Bladder Cancer: A Comprehensive Review

  2025cites this paper
• Determination of progoitrin, sinigrin, and glucoerucin contents and the expression pattern of aliphatic glucosinolates biosynthesis pathway genes in different maturity groups of cauliflower

  2025cites this paper
• Genotypic variation in sinigrin, progoitrin and glucoerucin content in four thermosensitive groups of Indian cauliflower (Brassica oleracea var. botrytis L.)

  2025cites this paper
• Exploring the broad-spectrum activity of carbohydrate-based Iberin analogues: From anticancer effect to antioxidant properties.

  2025cites this paper
• Bioactive Compounds and Health Benefits of Radish Greens.

  2025cites this paper
• Characterization, biological activity, and anticancer effect of green-synthesized gold nanoparticles using Nasturtium officinale L.

  2024cites this paper
• Unravelling Glucoraphanin and Glucoerucin Metabolism across Broccoli Sprout Development: Insights from Metabolite and Transcriptome Analysis

  2024cites this paper
• Broccoli Sprout Extract Suppresses Particulate-Matter-Induced Matrix-Metalloproteinase (MMP)-1 and Cyclooxygenase (COX)-2 Expression in Human Keratinocytes by Direct Targeting of p38 MAP Kinase

  2024cites this paper
• Sulforaphane activates CD8+ T cells antitumor response through IL-12RB2/MMP3/FasL-induced MDSCs apoptosis’

  2024cites this paper
• Glucosinolates in cancer prevention and treatment: experimental and clinical evidence

  2023cites this paper
• Sulforaphane and bladder cancer: a potential novel antitumor compound

  2023cites this paper
• Absorption and Excretion of Glucosinolates and Isothiocyanates after Ingestion of Broccoli (Brassica oleracea L. var italica) Leaf Flour in Mice: A Preliminary Study

  2023cites this paper
• Natural Products as New Approaches for Treating Bladder Cancer: From Traditional Medicine to Novel Drug Discovery

  2023influential citation
• Can edible sprouts be the element of effective chemopreventive strategy? - A systematic review of in vitro and in vivo study

  2023cites this paper
• Plant-Derived Sulforaphane Suppresses Growth and Proliferation of Drug-Sensitive and Drug-Resistant Bladder Cancer Cell Lines In Vitro

  2022cites this paper
• A Preliminary Study on the Technoeconomic Feasibility of Industrial-scale Microgreens Production

  2022cites this paper
• Hydrogen sulfide donors and inhibitors in cancer research: A state-of-the-art review

  2022influential citation
• The Dietary Isothiocyanate Erucin Reduces Kidney Cell Motility by Disturbing Tubulin Polymerization

  2022cites this paper
• THE USE OF BROCCOLI AND BROCCOLI SPROUTS IN THE PREVENTION AND TREATMENT OF VARIOUS DISEASES

  2022cites this paper
• Hydrogen sulfide-induced post-translational modification as a potential drug target

  2022cites this paper
• Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study

  2021cites this paper
• Current Knowledge and Challenges on the Development of a Dietary Glucosinolate Database in the United States.

  2021cites this paper
• Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma

  2021cites this paper
• Consumption of cruciferous vegetables and the risk of bladder cancer in a prospective US cohort: data from the NIH-AARP diet and health study.

  2021cites this paper
• Erucin inhibits osteoclast formation via suppressing cell–cell fusion molecule DC-STAMP without influencing mineralization by osteoblasts

  2021cites this paper
• Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential

  2021cites this paper
• Metabolism, absorption, and anti-cancer effects of sulforaphane: an update

  2021cites this paper
• The Green Anti-Cancer Weapon. The Role of Natural Compounds in Bladder Cancer Treatment

  2021cites this paper
• Simultaneous Hydrolysis and Extraction Increased Erucin Yield from Broccoli Seeds

  2021cites this paper
• Response of Broccoli Transplants to LED Light during Short and Long-Term Storage

  2020cites this paper
• Molecular Mechanisms of the Anti-Cancer Effects of Isothiocyanates from Cruciferous Vegetables in Bladder Cancer

  2020cites this paper
• Sulforaphane and its antioxidative effects in broccoli seeds and sprouts of different cultivars.

  2020cites this paper
• Targeting Major Signaling Pathways of Bladder Cancer with Phytochemicals: A Review

  2020cites this paper
• Vegetables.

  2020cites this paper
• Mechanisms Underlying Biological Effects of Cruciferous Glucosinolate-Derived Isothiocyanates/Indoles: A Focus on Metabolic Syndrome

  2020cites this paper
• Transcriptome reveals the gene expression patterns of sulforaphane metabolism in broccoli florets

  2019cites this paper
• Molecular targets in cancer prevention by 4-(methylthio)butyl isothiocyanate - A comprehensive review.

  2019cites this paper
• Isothiocyanate from Broccoli, Sulforaphane, and Its Properties

  2019cites this paper
• Anticancer properties of erucin, an H2S‐releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC‐1)

  2019cites this paper
• High-efficiency purification of sulforaphane from the broccoli extract by nanostructured SBA-15 silica using solid-phase extraction method.

  2019cites this paper
• Cancer Biomarkers for Integrative Oncology

  2019cites this paper
• Eruca sativa L-A promising source of drug lead for antimicrobial, neuroprotective and anticancer treatment regimens: Pharmacological properties of medicinal plant “Eruca sativa”

  2019cites this paper
• Dynamic variation of glucosinolates and isothiocyanates in broccoli sprouts during hydrolysis

  2019cites this paper
• Plant Products for Health

  2019cites this paper
• Sulforaphane inhibits non-muscle invasive bladder cancer cells proliferation through suppression of HIF-1α-mediated glycolysis in hypoxia.

  2019cites this paper
• Effect of preharvest CaCl2 spray and postharvest UV-B radiation on storage quality of broccoli microgreens, a richer source of glucosinolates

  2018cites this paper
• Sulforaphane Inhibits Liver Cancer Cell Growth and Angiogenesis

  2018cites this paper
• In Vitro Determination of Protein Conjugates in Human Cells by LC-ESI-MS/MS after Benzyl Isothiocyanate Exposure.

  2018cites this paper
• d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer

  2018cites this paper
• The primary active components, antioxidant properties, and differential metabolite profiles of radish sprouts (Raphanus sativus L.) upon domestic storage: analysis of nutritional quality.

  2018cites this paper
• Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease.

  2018cites this paper
• Sulforaphane and Its Relationship with the Intestinal Flora

  2018cites this paper
• Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention.

  2018cites this paper
• Relevance of the natural HDAC inhibitor sulforaphane as a chemopreventive agent in urologic tumors.

  2018cites this paper
• Anticancer activity of sulforaphane and allyl isothiocyanate- conjugated silicon quantum dots

  2017cites this paper
• Sulforaphane for the chemoprevention of bladder cancer: molecular mechanism targeted approach

  2017influential citation
• 4-(Methylthio)butyl isothiocyanate inhibits the proliferation of breast cancer cells with different receptor status

  2017cites this paper
• Improving In Vivo Efficacy of Bioactive Molecules: An Overview of Potentially Antitumor Phytochemicals and Currently Available Lipid-Based Delivery Systems

  2017cites this paper
• Functional foods and their role in cancer prevention and health promotion: a comprehensive review.

  2017cites this paper
• Anti-inflammatory effects of 1-isothiocyanato-7-(methylsulfonyl) heptane by suppressing the NFκ-B signaling pathway

  2017cites this paper
• Evaluating the Renoprotective Activity of 4-Methylthiobutyl Isothiocyanate against 7,12-Dimethylbenz(α) anthracene generated Radical Stress in Male Wistar Rats

  2017cites this paper
• The impact of cruciferous vegetable isothiocyanates on histone acetylation and histone phosphorylation in bladder cancer.

  2017cites this paper
• Reduction of the sulfoxide in glucoraphanin and sulforaphane by E. coli VL11 and BL21 (DE3)

  2016cites this paper
• Effects of CaCl2 on the metabolism of glucosinolates and the formation of isothiocyanates as well as the antioxidant capacity of broccoli sprouts

  2016cites this paper
• Increase of Bioactive Sulforaphane and Its Related Compounds with ( Brassica Oleracea Var . Italica

  2016cites this paper
• Mechanistic study of anti-tumor activity of sulforaphane on nasopharyngeal carcinoma

  2016cites this paper
• Withaferin A induces Nrf 2-dependent protection against liver injury : role of Keap 1-independent mechanisms

  2016cites this paper
• Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms.

  2016cites this paper
• Simultaneous Targeting of Bladder Tumor Growth, Survival, and Epithelial-to-Mesenchymal Transition with a Novel Therapeutic Combination of Acetazolamide (AZ) and Sulforaphane (SFN)

  2016cites this paper
• Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.

  2015cites this paper
• HPLC Fingerprinting of Glucosinolates during Fermentations Assisted by Chemometric Analysis

  2015cites this paper
• Sensitization of estrogen receptor-positive breast cancer cell lines to 4-hydroxytamoxifen by isothiocyanates present in cruciferous plants

  2015cites this paper
• The Development, Sensory Evaluation and Interconversion of Bioactive Isothiocyanates in a Tomato-Soy-Arugula Seed Beverage

  2015influential citation
• Cancer Preventive and Therapeutic Properties of Fruits and Vegetables Against Commonly Occurring Cancers in Humans

  2015cites this paper
• Genetic Variability in Glucosinolates in Seed of Brassica juncea: Interest in Mustard Condiment

  2015cites this paper
• 4-Methylthiobutyl isothiocyanate (Erucin) from rocket plant dichotomously affects the activity of human immunocompetent cells.

  2015cites this paper
• The selective cytotoxicity of the alkenyl glucosinolate hydrolysis products and their presence in Brassica vegetables.

  2015cites this paper
• Near-silence of isothiocyanate carbon in (13)C NMR spectra: a case study of allyl isothiocyanate.

  2015cites this paper
• Cruciferous Vegetables, Isothiocyanates, and Prevention of Bladder Cancer

  2015cites this paper
• Sulforaphane (SFN): An Isothiocyanate in a Cancer Chemoprevention Paradigm

  2015cites this paper
• The isothiocyanate erucin abrogates telomerase in hepatocellular carcinoma cells in vitro and in an orthotopic xenograft tumour model of HCC

  2014cites this paper
• Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis

  2014cites this paper
• Brassica oleracea (Italica Group)

  2014cites this paper
• Isothiocyanate metabolism, distribution, and interconversion in mice following consumption of thermally processed broccoli sprouts or purified sulforaphane.

  2014influential citation
• Sulforaphane induces reactive oxygen species-mediated mitotic arrest and subsequent apoptosis in human bladder cancer 5637 cells.

  2014cites this paper
• Suppression of pro-inflammatory signalling pathways by sulforaphane

  2014cites this paper
• Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells

  2014cites this paper
• Sequential light programs shape kale (Brassica napus) sprout appearance and alter metabolic and nutrient content

  2014cites this paper
• Cancer control and prevention: nutrition and epigenetics

  2013cites this paper
• Erucin Exerts Anti-Inflammatory Properties in Murine Macrophages and Mouse Skin: Possible Mediation through the Inhibition of NFκB Signaling

  2013cites this paper
• The anti-cancer activity of Antrodia camphorata against human ovarian carcinoma (SKOV-3) cells via modulation of HER-2/neu signaling pathway.

  2013cites this paper
• Phytoalexins and other antifungal metabolites from crucifers: isolation, synthesis and biosynthesis

  2013cites this paper
• Biflorin, A Naphthoquinone, Inhibitsegfr in Breast Cancer Cells

  2013cites this paper
• Increase of Bioactive Sulforaphane and Its Related Sulfur Compounds in Broccoli ) Sprouts During

  2013cites this paper
• Assessment of the anticancer compounds Se-methylselenocysteine and glucosinolates in Se-biofortified broccoli (Brassica oleracea L. var. italica) sprouts and florets.

  2013cites this paper
• Thermally Processing Broccoli Sprouts Impacts the Metabolism of Bioactive Isothiocyanates in Mice

  2012cites this paper