Heart failure and cachexia: insights offered from molecular biology.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Frontiers in Bioscience

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2741/2682PMID 17981550
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases

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• Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility.

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• 681 Apoptosis versus active gene transcription in the skeletal muscle of patients with mild to moderate chronic heart failure. Relationship with exercise capacity

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  2006influential reference
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  2005influential reference
• Skeletal muscle myofibrillar protein metabolism in heart failure: relationship to immune activation and functional capacity.

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• Preservation of exercise capacity and lack of peripheral changes in asymptomatic patients with severely impaired left ventricular function.

  2001influential reference
• Experimental Heart Failure Beneficial Effects on Skeletal Muscle of the Angiotensin II Type 1 Receptor Blocker Irbesartan in

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• Acquired growth hormone resistance in patients with chronic heart failure: implications for therapy with growth hormone.

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• Cytokines and Cytokine Receptors in Advanced Heart Failure: An Analysis of the Cytokine Database from the Vesnarinone Trial (VEST)

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  1990cited by this paper
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