Negative feedback effects of gonadal steroids are preserved with aging in postmenopausal women.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Clinical Endocrinology and Metabolism

• Publication date

  2002-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/JCEM.87.5.8510PMID 11994380
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evidence that GnRH decreases with gonadal steroid feedback but increases with age in postmenopausal women.

  2002cited by this paper
• Decrease in gonadotropin-releasing hormone (GnRH) pulse frequency with aging in postmenopausal women.

  2000cited by this paper
• Estrogen receptor null mice: what have we learned and where will they lead us?

  1999cited by this paper
• Disappearance of endogenous luteinizing hormone is prolonged in postmenopausal women.

  1999cited by this paper
• Inhibin A and inhibin B responses to gonadotropin withdrawal depends on stage of follicle development.

  1999cited by this paper
• Neuroendocrine influences and repercussions of the menopause.

  1999cited by this paper
• Female reproductive aging is marked by decreased secretion of dimeric inhibin.

  1999cited by this paper
• Free alpha-subunit is superior to luteinizing hormone as a marker of gonadotropin-releasing hormone despite desensitization at fast pulse frequencies.

  1999cited by this paper
• Multimodal influence of estrogen upon gonadotropin-releasing hormone neurons.

  1998cited by this paper
• Effects of aging and gonadal failure on the hypothalamic-pituitary axis in women.

  1998cited by this paper
• Regulation of preoptic area gonadotrophin-releasing hormone (GnRH) mRNA expression by gonadal steroids in the long-term gonadectomized male rat.

  1997cited by this paper
• Post‐menopausal and chronological age have divergent effects on pituitary and hypothalamic function in episodic gonadotrophin secretion

  1997cited by this paper
• Gonadotropin-releasing hormone gene expression is increased in the medial basal hypothalamus of postmenopausal women.

  1996cited by this paper
• The midcycle gonadotropin surge in normal women occurs in the face of an unchanging gonadotropin-releasing hormone pulse frequency.

  1994cited by this paper
• Neuroendocrinology of aging in humans: attenuated sensitivity to sex steroid feedback in elderly postmenopausal women.

  1994cited by this paper
• Central regulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion by estradiol during the period leading up to the preovulatory GnRH surge in the ewe.

  1994cited by this paper
• Does the gonadotropin pulsatility of postmenopausal women represent the unrestrained hypothalamic-pituitary activity?

  1994cited by this paper
• Negative feedback effects of estrogen on luteinizing hormone-releasing hormone release occur in pubertal, but not prepubertal, ovariectomized female rhesus monkeys.

  1993cited by this paper
• Transdermal estradiol with oral progestin: biological and clinical effects in younger and older postmenopausal women.

  1991cited by this paper
• Gonadotropin secretion during aging in postmenopausal women.

  1991cited by this paper
• Serum Gonadotropins and α-Subunit Decline in Aging Normal Postmenopausal Women

  1990cited by this paper
• The effect of aging on hypothalamic function in oophorectomized women.

  1990cited by this paper
• Serum gonadotropins and alpha-subunit decline in aging normal postmenopausal women.

  1990cited by this paper
• Utility of free alpha-subunit as an alternative neuroendocrine marker of gonadotropin-releasing hormone (GnRH) stimulation of the gonadotroph in the human: evidence from normal and GnRH-deficient men.

  1990cited by this paper
• Molecular biology of the pituitary gonadotropins.

  1990cited by this paper
• The roles of estradiol and progesterone in decreasing luteinizing hormone pulse frequency in the luteal phase of the menstrual cycle.

  1989cited by this paper
• INFLUENCE OF OESTRADIOL AND PROGESTERONE ON PULSATILE LH SECRETION IN POSTMENOPAUSAL WOMEN

  1989cited by this paper
• The role of the hypothalamus in aging of the female reproductive system.

  1987cited by this paper
• Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection.

  1986cited by this paper
• Neuroendocrine regulation of the corpus luteum in the human. Evidence for pulsatile progesterone secretion.

  1984cited by this paper
• Progesterone modulation of pulsatile luteinizing hormone secretion in normal women.

  1984cited by this paper
• THYROID HORMONE, OESTROGEN, AND GLUCOCORTICOID EFFECTS ON TWO DIFFERENT PITUITARY GLYCOPROTEIN HORMONE ALPHA SUBUNIT POOLS

  1978cited by this paper
• Plasma hormone profiles after the menopause and bilateral oöphorectomy.

  1978cited by this paper
• Hormonal profiles after the menopause.

  1976cited by this paper
• Regulation of human gonadotropins: 13. Changes in serum gonadotropins in menstruating women in response to oophorectomy.

  1972cited by this paper
• Regulation of human gondotropins. 13. Changes in serum gonadotropins in menstruating women in response to oophorectomy.

  1972cited by this paper
• The effect of ovariectomy on gonadotropin release.

  1971cited by this paper

• Evaluating the association between some fertility hormones and breast cancer progression in postmenopausal women

  2025cites this paper
• Effects of menopause on temperature regulation

  2025cites this paper
• Behavioral, Endocrine, and Neuronal Responses to Odors in Lampreys

  2025cites this paper
• Brenner Tumor of the Ovary in a Patient With Postmenopausal Bleeding: A Case Report

  2024cites this paper
• The role of gonadotropin‐releasing hormone neurons in polycystic ovary syndrome

  2022cites this paper
• Effectiveness of a 6-Month 22.5-mg Leuprolide Acetate Depot Formulation With Tamoxifen for Postoperative Premenopausal Estrogen Suppression in Hormone Receptor-Positive Breast Cancer

  2021cites this paper
• Hormones in aging

  2021cites this paper
• Neuroendocrinology of Reproduction

  2021cites this paper
• Change in Estradiol Levels among Premenopausal Patients with Breast Cancer Treated Using Leuprolide Acetate 11.25 Milligrams 3-Month Depot and Tamoxifen

  2020cites this paper
• Long-Term Follow Up and Treatment of a Female with Complete Estrogen Insensitivity.

  2020cites this paper
• Neuroendocrine Control of the Menstrual Cycle

  2019cites this paper
• Neurofibrillary Pathology in the Infundibular Nucleus in Relation to Age and Abnormal Hormone Levels

  2019cites this paper
• Progesterone-Mediated Inhibition of the GnRH Pulse Generator: Differential Sensitivity as a Function of Sleep Status

  2018cites this paper
• Menopause and HRT

  2018cites this paper
• Seasonal Reproduction in Vertebrates: Melatonin Synthesis, Binding, and Functionality Using Tinbergen’s Four Questions

  2018cites this paper
• Menopause: The Concepts and the Biological Background

  2017cites this paper
• Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response

  2017cites this paper
• Pathophysiology of hot flashes with focus on neurohormonal regulation (a review)

  2017cites this paper
• Endocrinology of the Menopause.

  2015cites this paper
• Aging and Reproduction

  2015cites this paper
• Attenuation of the oestrogen positive feedback mechanism with the age in postmenopausal women

  2015cites this paper
• Chapter 8 – Neuroendocrine Control of the Menstrual Cycle

  2014cites this paper
• G-protein coupled estrogen receptor, estrogen receptor α, and progesterone receptor immunohistochemistry in the hypothalamus of aging female rhesus macaques given long-term estradiol treatment.

  2014cites this paper
• Anatomy, Development, Histology, and Normal Function of the Ovary

  2014cites this paper
• The menopause and aging, a comparative perspective.

  2014cites this paper
• Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesis on the mechanism of hot flushes.

  2013cites this paper
• Estrogens and Neuropeptides in Postmenopausal Women: Un Update

  2012cites this paper
• Neuroendocrine Control of the Transition to Reproductive Senescence: Lessons Learned from the Female Rodent Model

  2012cites this paper
• Dehydroepiandrosterone sulfate levels reflect endogenous luteinizing hormone production and response to human chorionic gonadotropin challenge in older female macaque (Macaca fascicularis)

  2012cites this paper
• Differential Sleep-Wake Sensitivity of Gonadotropin-Releasing Hormone Secretion to Progesterone Inhibition in Early Pubertal Girls

  2012cites this paper
• Serum Level Change of Follicle Stimulating Hormone in Menopausal Women with Breast Cancer according to Age in Korea

  2011cites this paper
• Reproductive aging: insights from model organisms.

  2011cites this paper
• Differential effects of aging on estrogen negative and positive feedback.

  2011cites this paper
• The neuroendocrine physiology of female reproductive aging: An update.

  2010cites this paper
• The hypothalamic median eminence and its role in reproductive aging

  2010cites this paper
• Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence of female rhesus macaques.

  2010cites this paper
• Estrogen negative feedback on gonadotropin secretion: evidence for a direct pituitary effect in women.

  2010cites this paper
• Polycystic Ovary Syndrome in the Pediatric Population

  2010cites this paper
• Maturation of Sleep–Wake Gonadotrophin‐Releasing Hormone Secretion Across Puberty in Girls: Potential Mechanisms and Relevance to the Pathogenesis of Polycystic Ovary Syndrome

  2010cites this paper
• Neuroendocrine Aging: Hypothalamic-Pituitary-Gonadal Axis in Women

  2009cites this paper
• Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback.

  2009cites this paper
• Proximate mechanisms driving circadian control of neuroendocrine function: Lessons from the young and old.

  2009cites this paper
• Interrelationships between ovarian and pituitary hormones in ovulatory menstrual cycles across reproductive age.

  2009cites this paper
• Estradiol and progesterone-induced slowing of gonadotropin-releasing hormone pulse frequency is not reversed by subsequent administration of mifepristone

  2009cites this paper
• Aging attenuates the pituitary response to gonadotropin-releasing hormone.

  2009cites this paper
• Menopausal Symptom Experience of Hispanic Midlife Women in the United States

  2009cites this paper
• Menopausal symptom experience: an online forum study.

  2008cites this paper
• AN ONLINE FORUM ON MENOPAUSAL SYMPTOM EXPERIENCE OF WHITE WOMEN IN THE U.S

  2008cites this paper
• [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography demonstration of estrogen negative and positive feedback on luteinizing hormone secretion in women.

  2008cites this paper
• E-cadherin expression in cervical epithelial cells of postmenopausal women: association with hormone therapy, tibolone, and raloxifene.

  2008cites this paper
• Polycystic Ovary Syndrome in Adolescence

  2008cites this paper
• Hot flash severity in hormone therapy users/nonusers across the menopausal transition.

  2007cites this paper
• Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys.

  2007cites this paper
• Neuroendocrine changes with reproductive aging in women.

  2007cites this paper
• Neuroendocrine Changes with Reproductive Aging in Women

  2007cites this paper
• Neuroendocrine Effects of Androgens in Adult Polycystic Ovary Syndrome and Female Puberty

  2007cites this paper
• Neuroendocrine effects of androgens in adult polycystic ovary syndrome and female puberty.

  2007cites this paper
• Endogener Opioidtonus bei postmenopausalen Frauen unter differenzierter Hormonersatztherapie

  2006influential citation
• The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome.

  2006cites this paper
• Short term changes in melatonin and cortisol serum levels after a single administration of estrogen to menopausal women.

  2006cites this paper
• Absence of Apparent Circadian Rhythms of Gonadotropins and Free α-Subunit in Postmenopausal Women: Evidence for Distinct Regulation Relative to Other Hormonal Rhythms

  2006cites this paper
• Aging in the Hypothalamic-Pituitary-Ovarian Axis

  2006cites this paper
• A Descriptive Internet Survey on Menopausal Symptoms: Five Ethnic Groups of Asian American University Faculty and Staff

  2005cites this paper
• Effect of anovulation factors on pre- and postmenopausal ovarian cancer risk: revisiting the incessant ovulation hypothesis.

  2005cites this paper
• Androgen insufficiency in women: diagnostic and therapeutic implications

  2004cites this paper
• Androgen insufficiency in women: diagnostic and therapeutic implications.

  2004cites this paper
• Changes in estrogen receptor-alpha and -beta in the infundibular nucleus of the human hypothalamus are related to the occurrence of Alzheimer's disease neuropathology.

  2004cites this paper
• Changes in estrogen receptor-α and -β in the infundibular nucleus of the human hypothalamus are related to the occurrence of Alzheimer's disease neuropathology

  2004cites this paper
• Neuroendocrine physiology of the early and late menopause.

  2004cites this paper
• Menopausal increases in pulsatile gonadotropin-releasing hormone release in a nonhuman primate (Macaca mulatta).

  2004cites this paper
• Pharmacodynamics of follicle stimulating hormone (FSH) in postmenopausal women during pulsed estrogen therapy: Evidence that FSH release and synthesis are controlled by distinct pathways.

  2003influential citation
• Control of follicle-stimulating hormone by estradiol and the inhibins: critical role of estradiol at the hypothalamus during the luteal-follicular transition.

  2003cites this paper
• Ovarian gonadotrophin surge-attenuating factor (GnSAF): where are we after 20 years of research?

  2003cites this paper
• Anti-Aging Medicine LiteratureWatch

  2002cites this paper
• Ageing: biology and nutrition Body composition and energy expenditure in ageing Related review: Body composition in aging: a biological perspective (pp 15–20)

  2002cites this paper
• Evidence that GnRH decreases with gonadal steroid feedback but increases with age in postmenopausal women.

  2002cites this paper