Protective Effect of Glycyrrhizin on 1-Methyl-4-phenylpyridinium-Induced Mitochondrial Damage and Cell Death in Differentiated PC12 Cells

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2007-05-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1124/jpet.107.119602PMID 17314199
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008influential reference
• Role of mitochondria as the gardens of cell death

  2006cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• Mitochondrial reactive oxygen species in cell death signaling.

  2002influential reference
• Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression.

  2002cited by this paper
• A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice.

  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism.

  1999cited by this paper
• Mechanisms of MPTP toxicity.

  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1992influential reference
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  1992cited by this paper
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  1988influential reference
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  1988cited by this paper
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  1983cited by this paper

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  2020cites this paper
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