Zidovudine treatment prolongs survival and decreases virus load in the central nervous system of rhesus macaques infected perinatally with simian immunodeficiency virus.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Journal of Infectious Diseases

• Publication date

  1995-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/INFDIS/172.1.59PMID 7797947
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cytopathologic and Neurochemical Correlates of Progression to Motor/Cognitive Impairment in SIV-lnfected Rhesus Monkeys

  1994cited by this paper
• Relation of the course of HIV infection in children to the severity of the disease in their mothers at delivery

  1994cited by this paper
• Evaluation of the quality of life associated with zidovudine treatment in asymptomatic human immunodeficiency virus infection. The AIDS Clinical Trials Group.

  1994cited by this paper
• Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.

  1994cited by this paper
• A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.

  1993cited by this paper
• Preliminary analysis of the Concorde trial

  1993cited by this paper
• Zidovudine Toxicity

  1993cited by this paper
• 4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).

  1993cited by this paper
• Neonatal Disease Induced by SIV Infection of the Rhesus Monkey (Macaca mulatta)

  1993cited by this paper
• Effects of initiation of 3'-azido,3'-deoxythymidine (zidovudine) treatment at different times after infection of rhesus monkeys with simian immunodeficiency virus.

  1993cited by this paper
• Early viremia and immune responses in vertical human immunodeficiency virus type 1 infection.

  1993cited by this paper
• Preliminary analysis of the Concorde trial. Concorde Coordinating Committee.

  1993cited by this paper
• Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid.

  1992cited by this paper
• HIV replication during the first weeks of life

  1992cited by this paper
• The use of viral culture and p24 antigen testing to diagnose human immunodeficiency virus infection in neonates

  1992cited by this paper
• Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.

  1992cited by this paper
• Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid.

  1992cited by this paper
• A controlled trial of early versus late treatment with zidovudine in symptomatic human immunodeficiency virus infection. Results of the Veterans Affairs Cooperative Study.

  1992cited by this paper
• Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse.

  1992cited by this paper
• Cognitive and motor impairments associated with SIV infection in rhesus monkeys.

  1992cited by this paper
• SOME BIOCHEMICAL STUDIES ON PSILOCYBIN AND PSILOCIN

  1992cited by this paper
• Quality-of-life evaluation in a clinical trial of zidovudine therapy in patients with mildly symptomatic HIV infection. The AIDS Clinical Trials Group.

  1992cited by this paper
• Progressive slowing of reaction time and increasing cerebrospinal fluid concentrations of quinolinic acid in HIV-infected individuals.

  1992cited by this paper
• Simian immunodeficiency virus (SIV) infection of infant rhesus macaques as a model to test antiretroviral drug prophylaxis and therapy: oral 3'-azido-3'-deoxythymidine prevents SIV infection

  1992cited by this paper
• Postnatal transmission of human immunodeficiency virus type 1 from mother to infant.

  1991cited by this paper
• Transmission of human immunodeficiency virus infection by breast-feeding.

  1991cited by this paper
• High risk of HIV-1 infection for first-born twins. The International Registry of HIV-exposed Twins.

  1991cited by this paper
• Postexposure chemoprophylaxis with ZDV or ZDV combined with interferon-alpha: failure after inoculating rhesus monkeys with a high dose of SIV.

  1991cited by this paper
• HIV in pregnant women and their offspring: evidence for late transmission.

  1991cited by this paper
• A multicenter trial of oral zidovudine in children with advanced human immunodeficiency virus disease. The Protocol 043 Study Group.

  1991cited by this paper
• Placebo-controlled trial to evaluate zidovudine in treatment of human immunodeficiency virus infection in asymptomatic patients with hemophilia. NHF-ACTG 036 Study Group.

  1991cited by this paper
• Quantitation of human immunodeficiency virus in vertically infected infants and children.

  1991cited by this paper
• Antiviral effects of 3'-fluorothymidine and 3'-azidothymidine in cynomolgus monkeys infected with simian immunodeficiency virus.

  1991cited by this paper
• Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

  1991cited by this paper
• Prevalence of HIV infection in childbearing women in the United States. Surveillance using newborn blood samples.

  1991cited by this paper
• Postnatal transmission of human immunodeficiency virus type 1 from mother to infant. A prospective cohort study in Kigali, Rwanda.

  1991cited by this paper
• Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases.

  1990cited by this paper
• The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection. A double-blind, placebo-controlled trial. The AIDS Clinical Trials Group.

  1990cited by this paper
• Zidovudine intolerance.

  1990cited by this paper
• Survival in children with perinatally acquired human immunodeficiency virus type 1 infection

  1990cited by this paper
• Zidovudine in Asymptomatic Human Immunodeficiency Virus Infection

  1990cited by this paper
• A prospective study of infants born to women seropositive for human immunodeficiency virus type 1

  1990cited by this paper
• Pharmacokinetics of zidovudine (azidothymidine). II. Development of metabolic and renal clearance pathways in the neonate.

  1990cited by this paper
• Pharmacokinetics of subcutaneous azidothymidine in rhesus monkeys

  1989cited by this paper
• Natural history and serologic diagnosis of infants born to human immunodeficiency virus-infected women.

  1989cited by this paper
• Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome

  1989cited by this paper
• Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome.

  1989cited by this paper
• Prolonged exposure to submicromolar concentrations of quinolinic acid causes excitotoxic damage in organotypic cultures of rat corticostriatal system.

  1989cited by this paper
• Pharmacokinetics of zidovudine administered intravenously and orally in children with human immunodeficiency virus infection.

  1989cited by this paper
• Necropsy Findings in Rhesus Monkeys Experimentally Infected with Cultured Simian Immunodeficiency Virus (SIV)/Delta

  1988cited by this paper
• Incubation periods for paediatric AIDS patients

  1988cited by this paper
• Pediatric acquired immunodeficiency syndrome. Neurologic syndromes.

  1988cited by this paper
• Neurological and neuropathological features of human immunodeficiency virus infection in children

  1988cited by this paper
• Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection

  1988influential reference
• Vertical transmission of HIV in 15-week fetus.

  1986cited by this paper
• Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.

  1986cited by this paper
• Neurologic manifestations of human immunodeficiency virus infection in children.

  1986cited by this paper
• Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.

  1986cited by this paper
• LAV/HTLV-III in 20-week fetus.

  1985cited by this paper
• Quinolinic acid: regional variations in neuronal sensitivity.

  1983cited by this paper
• Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain.

  1983cited by this paper

• Antiretroviral Treatment in HIV-1-Positive Mothers: Neurological Implications in Virus-Free Children

  2017cites this paper
• Of mice and monkeys: can animal models be utilized to study neurological consequences of pediatric HIV-1 infection?

  2015cites this paper
• Combination Nucleoside/Nucleotide Reverse Transcriptase Inhibitors for Treatment of HIV Infection

  2012cites this paper
• Evaluation of antiretrovirals in animal models of HIV infection.

  2010cites this paper
• Involvement of quinolinic acid in aids dementia complex

  2009cites this paper
• Pediatric AIDS: Maternal-Fetal and Maternal-Infant Transmission of Lentiviruses and Effects on Infant Development in Nonhuman Primates

  2008cites this paper
• SIV Infection of Macaques as a Model for AIDS Drug Studies

  2006cites this paper
• In vivo Models of HIV Disease and Control

  2006cites this paper
• SIV as a Model for AIDS Pathogenesis Studies

  2006cites this paper
• Neuropsychopathology in the SIV/macaque model of AIDS.

  2005cites this paper
• Antiretroviral drug studies in nonhuman primates: a valid animal model for innovative drug efficacy and pathogenesis experiments.

  2005cites this paper
• Cognitive and motor deficits associated with HIV-2287 infection in infant pigtailed macaques: A nonhuman primate model of pediatric neuro-AIDS

  2005cites this paper
• RNA interference:a potential novel therapeutic combating HIV-1 in the central nervous system.

  2004cites this paper
• Effects of HIV-1 Vpr on Neuroinvasion and Neuropathogenesis

  2004cites this paper
• Chapter 10 – Simian Retroviruses

  2004cites this paper
• Macaque animal model for HIV-induced neurological disease

  2002cites this paper
• Enhanced detection of Theiler's virus RNA copy equivalents in the mouse central nervous system by real-time RT-PCR.

  2002cites this paper
• Simian immunodeficiency virus model of HIV-induced central nervous system dysfunction.

  2001cites this paper
• Of mice and men

  2000cites this paper
• The ketogenic diet

  2000cites this paper
• Animal Models of HIV Infection

  1999cites this paper
• Public Health Service Guidelines for the Management of Health-Care Worker Exposures to HIV and Recommendations for Postexposure Prophylaxis. Vol. 47/No. RR-7.

  1998cites this paper
• Longitudinal analysis of behavioral, neurophysiological, viral and immunological effects of SIV infection in rhesus monkeys

  1998cites this paper
• Chronic exposure of human neurons to quinolinic acid results in neuronal changes consistent with AIDS dementia complex

  1998cites this paper
• Reducing the risk of perinatal HIV‐1 transmission with zidovudine: results and implications of AIDS Clinical Trials Group protocol 076

  1997cites this paper
• Pathogenesis of HIV infection in children

  1997cites this paper
• Interaction between timing of perinatal human immunodeficiency virus infection and the design of preventive and therapeutic interventions

  1997cites this paper
• Quinolinic Acid Levels in a Murine Retrovirus‐Induced Immunodeficiency Syndrome

  1996cites this paper