Neonatal sevoflurane anesthesia induces long-term memory impairment and decreases hippocampal PSD-95 expression without neuronal loss.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  European Review for Medical and Pharmacological Sciences

• Publication date

  2013-04-01

• Fields of study

  Medicine

• Identifiers
  PMID 23640442
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

  2012cited by this paper
• Acute ethanol exposure affects spermatogonial stem cell homeostasis in pre-pubertal mice.

  2012cited by this paper
• Isoflurane induces cognitive deficits in the Morris water maze task in rats

  2012cited by this paper
• Chronic exposure of gestation rat to sevoflurane impairs offspring brain development

  2012cited by this paper
• The effects of metabotropic glutamate receptor 7 allosteric agonist N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride on developmental sevoflurane neurotoxicity: role of extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase signaling pathway.

  2012cited by this paper
• Neonatal exposure to sevoflurane causes apoptosis and reduces nNOS protein expression in rat hippocampus.

  2012cited by this paper
• Astrocyte-Originated ATP Protects Aβ1-42-Induced Impairment of Synaptic Plasticity

  2012cited by this paper
• Single sevoflurane exposure decreases neuronal nitric oxide synthase levels in the hippocampus of developing rats.

  2012cited by this paper
• PSD-95 Is Required to Sustain the Molecular Organization of the Postsynaptic Density

  2011cited by this paper
• PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity.

  2011cited by this paper
• Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey.

  2011cited by this paper
• Early anesthetic exposure and long-term cognitive impairment.

  2011cited by this paper
• Rats Exposed to Isoflurane In Utero during Early Gestation Are Behaviorally Abnormal as Adults

  2011cited by this paper
• [Roles of glutamatergic and GABAergic nervous system in hypnotic and analgesic actions of general anesthetics].

  2011cited by this paper
• Isoflurane Impairs Immature Astroglia Development In Vitro: The Role of Actin Cytoskeleton

  2011cited by this paper
• Effects of Neonatal Stress and Morphine on Murine Hippocampal Gene Expression

  2011cited by this paper
• Hippocampal neuronal death induced by kainic acid and restraint stress is suppressed by exercise.

  2011cited by this paper
• Early childhood general anaesthesia exposure and neurocognitive development.

  2010cited by this paper
• N‐Methyl‐d‐aspartate receptor subunit‐ and neuronal‐type dependence of excitotoxic signaling through post‐synaptic density 95

  2010cited by this paper
• Isoflurane Causes Greater Neurodegeneration Than an Equivalent Exposure of Sevoflurane in the Developing Brain of Neonatal Mice

  2010cited by this paper
• Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95

  2010cited by this paper
• Is there any relationship between long-term behavior disturbance and early exposure to anesthesia?

  2010cited by this paper
• Low Concentrations of Alcohol Inhibit BDNF-Dependent GABAergic Plasticity via L-type Ca2+ Channel Inhibition in Developing CA3 Hippocampal Pyramidal Neurons

  2010cited by this paper
• Structure and composition of the postsynaptic density during development

  2010cited by this paper
• Nitrous Oxide Plus Isoflurane Induces Apoptosis and Increases &bgr;-Amyloid Protein Levels

  2009cited by this paper
• A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors

  2009cited by this paper
• Isoflurane Differentially Affects Neurogenesis and Long-term Neurocognitive Function in 60-day-old and 7-day-old Rats

  2009cited by this paper
• The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels.

  2009cited by this paper
• Neurodegeneration in Newborn Rats Following Propofol and Sevoflurane Anesthesia

  2009cited by this paper
• Neonatal Exposure to Sevoflurane Induces Abnormal Social Behaviors and Deficits in Fear Conditioning in Mice

  2009cited by this paper
• The Effects of Neonatal Isoflurane Exposure in Mice on Brain Cell Viability, Adult Behavior, Learning, and Memory

  2009cited by this paper
• An Assessment of the Effects of General Anesthetics on Developing Brain Structure and Neurocognitive Function

  2008cited by this paper
• MAGUK proteins: new targets for pharmacological intervention in the glutamatergic synapse.

  2008cited by this paper
• Differential interaction of NMDA receptor subtypes with the post‐synaptic density‐95 family of membrane associated guanylate kinase proteins

  2008cited by this paper
• Neuroimaging analysis of an anesthetic gas that blocks human emotional memory

  2008cited by this paper
• Amnestic Concentrations of Sevoflurane Inhibit Synaptic Plasticity of Hippocampal CA1 Neurons through γ-Aminobutyric Acid–mediated Mechanisms

  2008cited by this paper
• Pro: Anesthesia-induced Developmental Neuroapoptosis: Status of the Evidence

  2008cited by this paper
• Spatial memory formation induces recruitment of NMDA receptor and PSD‐95 to synaptic lipid rafts

  2008cited by this paper
• Isoflurane-induced Neuroapoptosis in the Developing Brain of Nonhypoglycemic Mice

  2008cited by this paper
• NMDA receptor desensitization regulated by direct binding to PDZ1-2 domains of PSD-95.

  2008cited by this paper
• Use of Anesthetic Agents in Neonates and Young Children

  2007cited by this paper
• Extrapolating brain development from experimental species to humans.

  2007cited by this paper
• General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain

  2006cited by this paper
• Molecular and systemic mechanisms of general anaesthesia: the ‘multi-site and multiple mechanisms’ concept

  2005cited by this paper
• Sevoflurane Depresses Glutamatergic Neurotransmission to Brainstem Inspiratory Premotor Neurons but Not Postsynaptic Receptor Function in a Decerebrate Dog Model

  2005cited by this paper
• Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways.

  2005cited by this paper
• Long-term Impairment of Acquisition of a Spatial Memory Task following Isoflurane–Nitrous Oxide Anesthesia in Rats

  2004cited by this paper
• Role for a cortical input to hippocampal area CA1 in the consolidation of a long-term memory

  2004cited by this paper
• Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity.

  2004cited by this paper
• Neonatal Alcohol Exposure Induces Long-Lasting Impairment of Visual Cortical Plasticity in Ferrets

  2003cited by this paper
• Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits

  2003cited by this paper
• Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

  2002cited by this paper
• PDZ domains and the organization of supramolecular complexes.

  2001cited by this paper
• Hippocampal Synaptic Plasticity Involves Competition between Ca2+/Calmodulin-Dependent Protein Kinase II and Postsynaptic Density 95 for Binding to the NR2A Subunit of the NMDA Receptor

  2001cited by this paper
• Molecular determinants of NMDA receptor internalization

  2001cited by this paper
• Mechanism and role of PDZ domains in signaling complex assembly.

  2001cited by this paper
• Effects of Sevoflurane on Excitatory Neurotransmission to Medullary Expiratory Neurons and on Phrenic Nerve Activity in a Decerebrate Dog Model

  2001cited by this paper
• Alteration of expression levels of neuronal nitric oxide synthase and haem oxygenase-2 messenger RNA in the hippocampi and cortices of young adult and aged cognitively unimpaired and impaired Long-Evans rats.

  2000cited by this paper
• PSD-95 involvement in maturation of excitatory synapses.

  2000cited by this paper
• Signal-processing machines at the postsynaptic density.

  2000cited by this paper
• Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice

  2000cited by this paper
• Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein.

  1999cited by this paper
• αCaMKII binding to the C‐terminal tail of NMDA receptor subunit NR2A and its modulation by autophosphorylation

  1999cited by this paper
• PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.

  1999cited by this paper
• Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

  1998cited by this paper
• A role for the Ras signalling pathway in synaptic transmission and long-term memory

  1997cited by this paper
• Binding of neuroligins to PSD-95.

  1997cited by this paper
• Excitotoxicity and alcohol-related brain damage.

  1993cited by this paper
• NMDA Receptors: Role in Ethanol Withdrawal Seizures

  1992cited by this paper
• The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein.

  1992cited by this paper
• N-methyl-D-aspartate receptor antagonists disrupt the formation of a mammalian neural map.

  1992cited by this paper
• NMDA receptor agonist and antagonists alter retinal ganglion cell arbor structure in the developing frog retinotectal projection

  1990cited by this paper
• NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons.

  1989cited by this paper
• Place navigation impaired in rats with hippocampal lesions

  1982cited by this paper
• Comparative aspects of the brain growth spurt.

  1979cited by this paper
• Changes in brain weights during the span of human life: Relation of brain weights to body heights and body weights

  1978cited by this paper
• Pdz Proteins Organize Minireview Synaptic Signaling Pathways

  year unknowncited by this paper

• GluN2B‐Derived Small Interfering Peptide (GluN2B‐Sip) Protects Against Sevoflurane‐Induced Neurotoxicity in Developing Rats

  2025cites this paper
• Abdominal Surgery under Ketamine Anesthesia during Second Trimester Impairs Hippocampal Learning and Memory of Offspring by Regulating Dendrite Spine Remodeling in Rats.

  2024cites this paper
• A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity

  2024cites this paper
• Research progress in the clinical application of inhaled anesthetic sevoflurane

  2024cites this paper
• Novel insights into sevoflurane-induced developmental neurotoxicity mechanisms.

  2024cites this paper
• Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology

  2024cites this paper
• Multiple Sevoflurane Exposures During the Neonatal Period Cause Hearing Impairment and Loss of Hair Cell Ribbon Synapses in Adult Mice

  2022cites this paper
• Propofol impairs specification of retinal cell types in zebrafish by inhibiting Zisp-mediated Noggin-1 palmitoylation and trafficking

  2021cites this paper
• Mechanistic insight into sevoflurane-associated developmental neurotoxicity

  2021cites this paper
• Effects of General Anesthetics on Synaptic Transmission and Plasticity

  2021cites this paper
• Neuroinflammation Induction and Alteration of Hippocampal Neurogenesis in Mice Following Developmental Exposure to Gossypol

  2020cites this paper
• Sevoflurane-induced neuronal apoptosis in neonatal mice is prevented with intranasal administration of insulin.

  2020influential citation
• Propofol impairs specification of retinal cell types in zebrafish by inhibiting Zisp-mediated Noggin-1 palmitoylation and trafficking

  2020cites this paper
• Hypoxia, hypercarbia, and mortality reporting in studies of anaesthesia-related neonatal neurodevelopmental delay in rodent models: A systematic review.

  2020cites this paper
• Key miRNAs associated with memory and learning disorder upon exposure to sevoflurane determined by RNA sequencing

  2020cites this paper
• Propofol Impairs Speci cation of Retinal Cell Types in Zebra sh by Inhibiting Zisp-mediated Noggin-1 Palmitoylation and Tra cking

  2020cites this paper
• Impairment of cognitive function induced by Shati/Nat8l overexpression in the prefrontal cortex of mice.

  2020cites this paper
• Inhibition of RhoA Activity Does Not Rescue Synaptic Development Abnormalities and Long-Term Cognitive Impairment After Sevoflurane Exposure

  2020cites this paper
• Patent highlights June-July 2020.

  2020cites this paper
• Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient.

  2019cites this paper
• Efeitos da exposição repetida a diferentes concentrações de sevoflurano sobre o hipocampo de ratos neonatos

  2019cites this paper
• Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer’s disease model mice

  2019cites this paper
• Inhalational Aesthetic Sevoflurane Exacerbates Eye Phenotype of SCA3 Transgenic Drosophila Model

  2019cites this paper
• Neuroinflammation in the Developing Brain: Risk Factors, Involvement of Microglial Cells, and Implication for Early Anesthesia

  2019cites this paper
• Anesthetics: From modes of action to unconsciousness and neurotoxicity.

  2019cites this paper
• Signaling network between the dysregulated expression of microRNAs and mRNAs in propofol-induced developmental neurotoxicity in mice

  2018cites this paper
• Effects of repeated exposure to different concentrations of sevoflurane on the neonatal mouse hippocampus

  2018cites this paper
• Dexmedetomidine Ameliorates the Neurotoxicity of Sevoflurane on the Immature Brain Through the BMP/SMAD Signaling Pathway

  2018cites this paper
• Autophagy is involved in sevoflurane-induced developmental neurotoxicity in the developing rat brain.

  2018cites this paper
• Role of autophagy in sevoflurane-induced neurotoxicity in neonatal rat hippocampal cells.

  2018cites this paper
• Neonatal Exposure to Low-Dose (1.2%) Sevoflurane Increases Rats’ Hippocampal Neurogenesis and Synaptic Plasticity in Later Life

  2018cites this paper
• Intranasal cerebrolysin improves cognitive function and structural synaptic plasticity in photothrombotic mouse model of medial prefrontal cortex ischemia.

  2018cites this paper
• Methamphetamine augment HIV-1 Tat mediated memory deficits by altering the expression of synaptic proteins and neurotrophic factors.

  2018cites this paper
• Long-term neurocognitive dysfunction in offspring via NGF/ ERK/CREB signaling pathway caused by ketamine exposure during the second trimester of pregnancy in rats

  2017cites this paper
• Chapter 5 Anesthetic Neurotoxicity in Pediatric Patients

  2017cites this paper
• Sevoflurane induces long-term memory impairment and increases MeCP 2 phosphorylation in developing mice

  2017cites this paper
• Anesthesia, brain changes, and behavior: Insights from neural systems biology

  2017influential citation
• Isoflurane exposure regulates the cell viability and BDNF expression of astrocytes via upregulation of TREK-1

  2017cites this paper
• Cyclin-dependent kinase 5/Collapsin response mediator protein 2 pathway may mediate sevoflurane-induced dendritic development abnormalities in rat cortical neurons.

  2017cites this paper
• Influence of sevoflurane exposure on mitogen-activated protein kinases and Akt/GSK-3β/CRMP-2 signaling pathways in the developing rat brain.

  2017cites this paper
• Effects of short-term exposure to sevoflurane on the survival, proliferation, apoptosis, and differentiation of neural precursor cells derived from human embryonic stem cells

  2017cites this paper
• Anesthetic Neurotoxicity in Pediatric Patients

  2017cites this paper
• Pharmacological inhibition of PTEN attenuates cognitive deficits caused by neonatal repeated exposures to isoflurane via inhibition of NR2B‐mediated tau phosphorylation in rats

  2017cites this paper
• MicroRNA-181 inhibitor protects against sevoflurane-induced hippocampal apoptosis and memory impairment

  2016cites this paper
• The effect of celastrol on learning and memory in diabetic rats after sevoflurane inhalation

  2016cites this paper
• The mitochondrial division inhibitor Mdivi-1 rescues mammalian neurons from anesthetic-induced cytotoxicity

  2016cites this paper
• Altered hippocampal microRNA expression profiles in neonatal rats caused by sevoflurane anesthesia: MicroRNA profiling and bioinformatics target analysis

  2016cites this paper
• Anesthesia specific differences in a cardio-pulmonary resuscitation rat model; halothane versus sevoflurane.

  2016cites this paper
• Anaesthesia associated developmental neurotoxicity (AADN) 2015

  2016cites this paper
• Anesthetic Sevoflurane Causes Rho-Dependent Filopodial Shortening in Mouse Neurons

  2016cites this paper
• Dose-dependent effects of sevoflurane exposure during early lifetime on apoptosis in hippocampus and neurocognitive outcomes in Sprague-Dawley rats.

  2016cites this paper
• Early‐life single‐episode sevoflurane exposure impairs social behavior and cognition later in life

  2016cites this paper
• Anaesthesia in early childhood - is the development of the immature brain in danger?

  2016cites this paper
• Glycyrrhizin attenuates isoflurane-induced cognitive deficits in neonatal rats via its anti-inflammatory activity.

  2016cites this paper
• Inhalational agents in anesthesia induced developmental neurotoxicity – Recent advances

  2016cites this paper
• Argon as a potential strategy against the neurotoxicity of nitrous oxide and perinatal hypoxia/ischemia induced brain injury

  2016cites this paper
• Learning, memory and synaptic plasticity in hippocampus in rats exposed to sevoflurane

  2016cites this paper
• Role of histone acetylation in long-term neurobehavioral effects of neonatal Exposure to sevoflurane in rats.

  2016cites this paper
• The Protective Effects of Sufentanil Pretreatment on Rat Brains under the State of Cardiopulmonary Bypass

  2015cites this paper
• The gender difference in effect of sevoflurane exposure on cognitive function and hippocampus neuronal apoptosis in rats.

  2015cites this paper
• Risk of autistic disorder after exposure to general anaesthesia and surgery: A nationwide, retrospective matched cohort study

  2015cites this paper
• A Double-Edged Sword: Volatile Anesthetic Effects on the Neonatal Brain

  2014cites this paper
• Review: Effects of Anesthetics on Brain Circuit Formation

  2014cites this paper
• Isoflurane Impairs the Capacity of Astrocytes to Support Neuronal Development in a Mouse Dissociated Coculture Model

  2014cites this paper
• The effects of general anaesthesia on memory in children: a comparison between propofol and sevoflurane

  2014cites this paper
• Anaesthetics-Induced Neurotoxicity in Developing Brain: An Update on Preclinical Evidence

  2014cites this paper
• Neonatal ketamine exposure causes impairment of long-term synaptic plasticity in the anterior cingulate cortex of rats.

  2014cites this paper
• Toxic and protective effects of inhaled anaesthetics on the developing animal brain: Systematic review and update of recent experimental work

  2014cites this paper