Does telomere elongation lead to a longer lifespan if cancer is considered

As cell proliferation is limited due to the loss of telomere repeats in DNA of normal somatic cells during division, telomere attrition can possibly play an important role in determining the maximum life span of organisms as well as contribute to the process of biological ageing. With computer simulations of cell culture development in organisms, which consist of tissues of normal somatic cells with finite growth, we obtain an increase of life span and life expectancy for longer telomeric DNA in the zygote. By additionally considering a two-mutation model for carcinogenesis and indefinite proliferation by the activation of telomerase, we demonstrate that the risk of dying due to cancer can outweigh the positive effect of longer telomeres on the longevity.

• Publication year

  2005

• Venue

  Physica A-statistical Mechanics and Its Applications

• Publication date

  2005-07-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.physa.2005.08.043arXiv q-bio/0507006
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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