Localization of TRAIL/TRAILR in fetal pancreas.

AIM To observe the localization of TRAIL/TRAIR (DR4, DR5, DcR1, DcR2) in the fetal pancreas. METHODS Fetal pancreas of 32 weeks of pregnancy were obtained from induced abortions, embedded in paraffin, and 4-microm sections were prepared. The localization of TRAIL/TRAILR in fetal pancreas was investigated by fluorescence immunohistochemical method combined with laser scanning confocal microscopy. RESULTS TRAIL immunoreactive cells were mainly located on the periphery of the pancreas islets. There were a few DcR1 and DcR2 positive cells whereas there were no immunoreactive cells of DR4 and DR5 in the pancreas islets. In the acini and the ducts of the exocrine pancreas there were no TRAIL/TRAILR immunoreactive cells. CONCLUSION This study not only describes the distribution of TRAIL/TRAILR in the fetal pancreas, but also provides a morphological basis for deducing the function of TRAIL/TRAILR in pancreas, suggesting that in normal pancreatic islets, the pancreatic cells are resistant towards apoptosis too.

• Publication year

  2003

• Venue

  World Journal of Gastroenterology

• Publication date

  2003-02-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3748/WJG.V9.I2.334PMID 12532461PMCID PMC4611341
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Influencing factors of pancreatic microcirculatory impairment in acute panceatitis.

  2002cited by this paper
• Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFκB activation in epithelial derived cell lines

  2002cited by this paper
• T and B leukemic cell lines exhibit different requirements for cell death: correlation between caspase activation, DFF40/DFF45 expression, DNA fragmentation and apoptosis in T cell lines but not in Burkitt's lymphoma

  2002cited by this paper
• Tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in human articular chondrocytes in vitro.

  2002cited by this paper
• Tumor-specific down-regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation.

  2002cited by this paper
• Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor

  2002cited by this paper
• IFN-gamma inhibition of TRAIL-induced IAP-2 upregulation, a possible mechanism of IFN-gamma-enhanced TRAIL-induced apoptosis.

  2002cited by this paper
• Hepatic DR5 Induces Apoptosis and Limits Adenovirus Gene Therapy Product Expression in the Liver

  2002cited by this paper
• Endoplasmic reticulum calcium pool depletion-induced apoptosis is coupled with activation of the death receptor 5 pathway

  2002cited by this paper
• Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to apo2l/trail‐induced apoptosis

  2002cited by this paper
• Enhanced tumor killing by Apo2L/TRAIL and CPT-11 co-treatment is associated with p21 cleavage and differential regulation of Apo2L/TRAIL ligand and its receptors

  2002cited by this paper
• Ectopic Expression of Bcl-2 and Bcl-xL Inhibits Apoptosis Induced by TNF-Related Apoptosis-Inducing Ligand (TRAIL) Through Suppression of Caspases-8, 7, and 3 and BID Cleavage in Human Acute Myelogenous Leukemia Cell Line HL-60

  2002cited by this paper
• Reduced response of prostate cancer cells to TRAIL is modulated by NFkappaB-mediated inhibition of caspases and Bid activation.

  2002cited by this paper
• Inflammatory cytokine regulation of TRAIL-mediated apoptosis in thyroid epithelial cells

  2002cited by this paper
• Potentiation of Fas-mediated apoptosis by an engineered glycosylphosphatidylinositol-linked Fas

  2002cited by this paper
• Characteristics and mechanism of enzyme secretion and increase in [Ca2+]i in Saikosaponin(I) stimulated rat pancreatic acinar cells.

  2002cited by this paper
• Expression of tumor necrosis factor-alpha-related apoptosis-inducing ligand and its receptors in rat testis during development.

  2002cited by this paper
• Presence and density of common bile duct microlithiasis in acute biliary pancreatitis.

  2002cited by this paper
• COX‐2 inhibits Fas‐mediated apoptosis in cholangiocarcinoma cells

  2002cited by this paper
• IFN-γ Inhibition of TRAIL-Induced IAP-2 Upregulation, a Possible Mechanism of IFN-γ-Enhanced TRAIL-Induced Apoptosis☆☆☆

  2002cited by this paper
• Evidence that the human death receptor 4 is regulated by activator protein 1

  2002cited by this paper
• Tumor-Infiltrating CD4+ T Lymphocytes Express APO2 Ligand (APO2L)/TRAIL upon Specific Stimulation with Autologous Lung Carcinoma Cells: Role of IFN-α on APO2L/TRAIL Expression and -Mediated Cytotoxicity1

  2002cited by this paper
• TRAIL, Fasl and a blocking anti‐DR5 antibody augment paclitaxel‐induced apoptosis in human non‐small‐cell lung cancer

  2002cited by this paper
• Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance.

  2002cited by this paper
• Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics

  2002cited by this paper
• Adjuvant therapy in pancreatic cancer.

  2001cited by this paper
• Stress kinase inhibition modulates acute experimental pancreatitis.

  2001cited by this paper
• Tumor necrosis factor-related apoptosis-inducing ligand in T cell development: Sensitivity of human thymocytes

  2001cited by this paper
• Differential expression of TRAIL-R3 and TRAIL-R4 in human pancreatic cancer.

  2001cited by this paper
• Management of necrotizing pancreatitis.

  2001cited by this paper
• The Role of Leucine-Enkephalin on Insulin and Glucagon Secretion from Pancreatic Tissue Fragments of Normal and Diabetic Rats

  2001cited by this paper
• Pancreatic Adenocarcinoma Cell Lines Show Variable Susceptibility to TRAIL-Mediated Cell Death

  2001cited by this paper
• The TNF and TNF Receptor Review Superfamilies: Integrating Mammalian Biology

  2001cited by this paper
• Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand and Its Receptor Expression and the Pathway of Apoptosis in Human Pancreatic Cancer

  2001cited by this paper
• Taxotere resistance in SUIT Taxotere resistance in pancreatic carcinoma cell line SUIT 2 and its sublines.

  2001cited by this paper
• Expressions of chromogranin A and cathepsin D in human primary hepatocellular carcinoma.

  2000cited by this paper
• KAI1 gene is differently expressed in papillary and pancreatic cancer: influence on metastasis.

  2000cited by this paper
• Identification, localization and morphology of APUD cells in gastroenteropancreatic system of stomach-containing teleosts.

  2000cited by this paper
• Chemokines MCP-1 and RANTES in Isolated Rat Pancreatic Acinar Cells Treated with CCK and Ethanol In Vitro

  2000cited by this paper
• Hepatitis C virus may infect extrahepatic tissues in patients with hepatitis C.

  2000cited by this paper
• Management of necrotizing pancreatitis.

  1993cited by this paper

• Molecular mechanisms of death ligand‐mediated immune modulation: A gene therapy model to prolong islet survival in type 1 diabetes

  2008cites this paper
• High Levels of Endogenous Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Expression Correlate With Increased Cell Death in Human Pancreas

  2008cites this paper