Clinical significance of circulating proinsulin and C-peptide.

No abstract is available for this paper.

• Publication year

  1976

• Venue

  Recent Progress in Hormone Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/B978-0-12-571133-3.50017-9PMID 198859
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural changes involved in the folding of proinsulin.

  2009cited by this paper
• Control of juvenile diabetes mellitus and its relationship to endogenous insulin secretion as measured by C-peptide immunoreactivity.

  1977cited by this paper
• Determination of Free and Total Insulin and C-Peptide in Insulin-treated Diabetics

  1977cited by this paper
• Quantitation of Human Pancreatic Beta-cell Function by Immunoassay of C-Peptide in Urine

  1977cited by this paper
• Production of antisera to synthetic benzyloxycarbonyl-C-peptide of human proinsulin.

  1976cited by this paper
• Circadian variation of serum glucose, C-peptide immunoreactivity and free insulin in normal and insulin-treated diabetic pregnant subjects

  1976cited by this paper
• Circulating serum C-peptide. A brief review of diagnostic implications.

  1976cited by this paper
• Familial hyperproinsulinemia. An autosomal dominant defect.

  1976cited by this paper
• Serum proinsulin in normal and gestational diabetic pregnancy

  1976cited by this paper
• Insulin and proinsulin in normal and chemical diabetic children.

  1976cited by this paper
• Human C-peptide in normal and diabetic subjects

  1975cited by this paper
• Prolonged Suppression of Insulin Release by Insulin-Induced Hypoglycemia: Demonstration by C-Peptide Assay

  1975cited by this paper
• Demonstration of C-peptide immunoreactivity in various body fluids and clinical evaluation of the determination of urinary C-peptide immunoreactivity.

  1975cited by this paper
• Inordinately High Levels of Serum Immunoreactive Insulin in Monoclonal Immunoglobulinemia (On the Problem of “Big, Big Insulin”)

  1975cited by this paper
• Degradation of insulin in serum by insulin-specific protease.

  1975cited by this paper
• Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood.

  1975cited by this paper
• Serum Proinsulin in Children and Adolescents with Chemical Diabetes

  1975cited by this paper
• C-peptide analysis in diagnosis of factitial hypoglycemia in an insulin-dependent diabetic.

  1975cited by this paper
• Radioimmunological determination of human C-peptide in serum

  1975cited by this paper
• Carbohydrate metabolism in pregnancy: XIII. Relationships between plasma insulin and proinsulin during late pregnancy in normal and diabetic subjects.

  1975cited by this paper
• Plasma C-peptide and diagnosis of factitious hyperinsulinism. Study of an insulin-dependent diabetic patient with "spontaneous" hypoglycemia.

  1975cited by this paper
• Hypoglycemia and endogenous hyperinsulinism complicating diabetes mellitus. Application of the C-peptide assay to diagnosis and therapy.

  1975cited by this paper
• Plasma Proinsulin-Like Material in Insulin Treated Diabetics

  1974cited by this paper
• Plasma Proinsulin: Comparison of Insulin Specific Protease and Gel Filtration Assays

  1974cited by this paper
• C-peptide immunoreactivity (CPR): a new method for studying infants of insulin-treated diabetic mothers.

  1974cited by this paper
• Circulating proinsulin-like component in man: Increased proportion in hypoinsulinemic states

  1974cited by this paper
• Radioimmunoassay of human proinsulin C-peptide using synthetic human connecting peptide.

  1974cited by this paper
• Placental Transfer of Streptozotocin in the Rhesus Monkey

  1974cited by this paper
• Presumed insulinoma secreting a high-molecular-weight insulin analogue.

  1974cited by this paper
• Metabolism of endogenous proinsulin and insulin in man.

  1974cited by this paper
• Placental Transfer of Streptozotocin in the Rhesus Monkey

  1974cited by this paper
• Sequential changes in beta-cell function in insulin-treated diabetic patients assessed by C-peptide immunoreactivity.

  1973cited by this paper
• Biochemical and morphological investigations of 30 human insulinomas

  1973cited by this paper
• Metabolism of proinsulin, insulin, and C-peptide in the rat.

  1973cited by this paper
• Diabetic ketoacidosis associated with mumps virus infection. Occurrence in a patient with macroamylasemia.

  1973cited by this paper
• A comparative study on the metabolism of human insulin and porcine proinsulin in man.

  1973cited by this paper
• “Big, big insulin”

  1973cited by this paper
• Platelet survival and adhesiveness in recurrent venous thrombosis.

  1973cited by this paper
• Suppression of insulin release by fish-insulin-induced hypoglycaemia: with reference to the diagnosis of insulinomas.

  1973cited by this paper
• "Big, big insulin".

  1973cited by this paper
• Dynamic Synthesis and Release of Insulin and Proinsulin from Perifused Islets

  1973cited by this paper
• Studies on the conversion of proinsulin to insulin. 3. Studies in vitro with a crude secretion granule fraction isolated from rat islets of Langerhans.

  1973cited by this paper
• The metabolism of proinsulin and insulin by the liver.

  1972cited by this paper
• Hyperglycemia, Hypoglycemic Attacks, and Production of Anti-Insulin Antibodies Without Previous Known Immunization: Immunological and Functional Studies in a Patient

  1972cited by this paper
• Degradation of Insulin and Proinsulin by Various Organ Homogenates of Rat

  1972cited by this paper
• Studies on the secretion of newly synthesized proinsulin and insulin from isolated rat islets of Langerhans.

  1972cited by this paper
• Diabetic ketoacidosis: evidence for C-peptide and proinsulin secretion following recovery.

  1972cited by this paper
• Elevated insulin-binding capacity of serum proteins in a case with spontaneous hypoglycemia and mild diabetes not treated with insulin.

  1972cited by this paper
• Biologically active circulating proinsulin-like materials from an islet cell carcinoma patient

  1972cited by this paper
• "Big" insulin and the treatment of an islet cell carcinoma with streptozotocin.

  1972cited by this paper
• Glucose intolerance with hypokalemia: an increased proportion of circulating proinsulin-like component.

  1972cited by this paper
• Direct measurement of plasma proinsulin in normal and diabetic subjects.

  1972cited by this paper
• Plasma proinsulin in patients with functioning pancreatic islet cell tumors.

  1972cited by this paper
• Circulating C-peptide Immunoreactivity: Studies in Normals and Diabetic Patients

  1972cited by this paper
• Characterization of a rat liver protease with specificity for insulin.

  1972cited by this paper
• Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors.

  1971cited by this paper
• Studies on the conversion of proinsulin to insulin. I. Conversion in vitro with trypsin and carboxypeptidase B.

  1971cited by this paper
• Direct measurement of proinsulin in human plasma by the use of an insulin-degrading enzyme.

  1971cited by this paper
• Plasma and Pancreatic Insulin Concentrations in Adult Squirrel and Rhesus Monkeys

  1971cited by this paper
• Purification and Characterization of a Protease with Specificity for Insulin from Rat Muscle

  1971cited by this paper
• Circulating proinsulin-like material in patients with functioning insulinomas.

  1971cited by this paper
• Hypoglycemic activity and immunological half-life of porcine insulin and proinsulin in baboons and swine.

  1971cited by this paper
• A unique form of circulating insulin in human islet cell carcinoma.

  1971cited by this paper
• The structure of bovine proinsulin.

  1971cited by this paper
• Comparative Immunology of Bovine, Porcine and Human Proinsulins and C-peptides

  1970cited by this paper
• Conversion of proinsulin to insulin in a subcellular fraction from rat islets.

  1970cited by this paper
• Streptozotocin therapy for metastatic insulinoma.

  1970cited by this paper
• Clearance of Porcine Insulin, Proinsulin, and Connecting Peptide by the Isolated Rat Liver 1

  1970cited by this paper
• Identification of proinsulin and C-peptide in human serum by a specific immunoassay.

  1970cited by this paper
• Synthesis and release of proinsulin and insulin by human insulinoma tissue.

  1970cited by this paper
• Effect of streptozotocin on qualitative aspects of plasma insulin in a patient with a malignant islet cell tumor.

  1970cited by this paper
• Proinsulin secretion by a pancreatic beta-cell adenoma. Proinsulin and C-peptide secretion.

  1970cited by this paper
• Proinsulin content of pancreas in human fetuses of healthy mothers.

  1970cited by this paper
• Human serum proinsulin.

  1970cited by this paper
• The significance of immunoassayable insulin in urine.

  1969cited by this paper
• Plasma insulin: fluctuations in the "big" insulin component in man after glucose and other stimuli.

  1969cited by this paper
• Proinsulin and the biosynthesis of insulin.

  1969cited by this paper
• Secretion of Proinsulin C-Peptide by Pancreatic β Cells and its Circulation in Blood

  1969cited by this paper
• Significance of Human Plasma Insulin Sephadex Fractions

  1969cited by this paper
• Isolation and Properties of Proinsulin, Intermediate Forms, and Other Minor Components from Crystalline Bovine Insulin

  1968cited by this paper
• Physical studies on proinsulin-association behavior and conformation in solution.

  1968cited by this paper
• "Big insulin": a new component of plasma insulin detected by immunoassay.

  1968cited by this paper
• The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma.

  1967cited by this paper

• Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions

  2019cites this paper
• Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions.

  2018cites this paper
• THE ROLE OF THE PANCREATIC AMYLOID IN THE PATHOGENESIS OF TYPE 2 DIABETES

  2010cites this paper
• History and Diagnostic Significance of C-Peptide

  2008cites this paper
• Development of a feline proinsulin immunoradiometric assay and a feline proinsulin enzyme-linked immunosorbent assay (ELISA): a novel application to examine beta cell function in cats.

  2008cites this paper
• CHAPTER 2 – Translation and Posttranslational Processing of Gastrointestinal Peptides

  2006cites this paper
• Insulin-Mediated Increase in Sympathetic Nerve Activity is Attenuated by C-Peptide in Diabetic Rats

  2004cites this paper
• Biosynthesis of Insulin

  2001cites this paper
• C-peptide induces a concentration-dependent dilation of skeletal muscle arterioles only in presence of insulin

  1999cites this paper
• C-peptide induces a concentration-dependent dilation of skeletal muscle arterioles only in presence of insulin.

  1999cites this paper
• Protein hormone storage in secretory granules: mechanisms for concentration and sorting.

  1999cites this paper
• Biochemistry, Pathogenesis, and Laboratory Diagnosis of Endocrine Disorders of the Pancreas

  1997cites this paper
• Mass spectrometric and biological characterization of guinea-pig corticotrophin.

  1995cites this paper
• Pharmacokinetics and organ distribution of the sorbin C-terminal peptides.

  1994cites this paper
• Pharmacokinetics and organ distribution of the sorbin C-terminal peptides

  1994cites this paper
• The molar ratio of insulin to C-peptide. An aid to the diagnosis of hypoglycemia due to surreptitious (or inadvertent) insulin administration.

  1993cites this paper
• Pancreatic beta-cell function evaluated by intravenous glucose and glucagon stimulation. A comparison between insulin and C-peptide to measure insulin secretion.

  1992cites this paper
• Proinsulin: biosynthesis, conversion, assay methods and clinical studies.

  1991cites this paper
• Posttranslational Processing of Gut Peptides

  1989cites this paper
• Methods for Study of Carbohydrate Metabolism

  1989cites this paper
• A View of the History of Biology From an Islet of Langerhans

  1988cites this paper
• E-domain peptide of rat proinsulin-like growth factor-II: validation of a radioimmunoassay and measurement in culture medium and rat serum.

  1987cites this paper
• The Comparative Physiology of the Pancreatic Islets

  1987cites this paper
• Insulin Gene Mutations and Abnormal Products of the Human Insulin Gene

  1987cites this paper
• Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man

  1985cites this paper
• Increased reduction in fasting C-peptide is associated with islet cell antibodies in Type 1 (insulin-dependent) diabetic patients

  1985cites this paper
• Identification of a peptide fragment from the carboxyl-terminal extension region (E-domain) of rat proinsulin-like growth factor-II.

  1985cites this paper
• Neuronal secretory systems.

  1984cites this paper
• Plasma C‐peptide Levels Identify Insulin‐treated Diabetic Patients Suitable for Oral Hypoglycaemic Therapy

  1984cites this paper
• Golgi/granule processing of peptide hormone and neuropeptide precursors: A minireview

  1984cites this paper
• Improvement of metabolic control in diabetic patients during mebendazole administration: Preliminary studies

  1984cites this paper
• PROINSULIN IN HUMAN SERUM: PROBLEMS IN MEASUREMENT AND INTERPRETATION

  1984cites this paper
• INTRACELLULAR PROTEOLYTIC MECHANISMS IN THE BIOSYNTHESIS OF HORMONES AND PEPTIDE NEUROTRANSMITTERS

  1983cites this paper
• Hyperinsulinism after removal of a pheochromocytoma.

  1983cites this paper
• Mycoplasma hominis infection of the central nervous system in a neonate.

  1983cites this paper
• Insulin Synthesis, Storage and Secretion

  1983cites this paper
• Biosynthesis and periplasmic segregation of human proinsulin in Escherichia coli.

  1981cites this paper
• Simultaneous Assay of Immunoreactive f3-Lipotropin,

  1981cites this paper
• Simultaneous assay of immunoreactive beta-lipotropin, gamma-lipotropin, and beta-endorphin in plasma of normal human subjects, patients with ACTH/lipotropin hypersecretory syndromes, and patients undergoing chronic hemodialysis.

  1981cites this paper
• Circulating C-Peptide: Measurement and Clinical Application

  1981cites this paper
• Biosynthesis of insulin and glucagon.

  1981cites this paper
• Autoimmunity in insulin-dependent diabetes mellitus.

  1981cites this paper
• C-Peptide Measurement and its Clinical Usefulness: A Review

  1981cites this paper
• Isolation and biogenesis of a new peptide from pancreatic islets

  1981cites this paper
• A Major Loss in Islet Mass and B-cell Function Precedes Hyperglycemia in Mice Given Multiple Low Doses of Streptozotocin

  1981cites this paper
• Insulin-dependent diabetes mellitus: the initial lesion.

  1981cites this paper
• Use of an extracorporeal glucose monitor for the diagnosis and surgical treatment of an insulinoma

  1980cites this paper
• Multiple endocrine neoplasia type 1.

  1980cites this paper
• A High Performance Liquid Chromatographic Assessment of the Isolation of Bovine Proinsulin and a Synthetic Proinsulin Fragment

  1980cites this paper
• Attenuation of the pancreatic beta cell response to a meal following hypoglycaemia in man

  1980cites this paper
• Cultured Hepatoma Cells as a Model System for Studying Insulin Processing and Biologic Responsiveness

  1980cites this paper
• Peripheral Metabolism of Hormones: Clinical Implications 1

  1979cites this paper
• Metabolic Control in Diabetic Patients: Effect of Insulin-secretory Reserve (Measured by Plasma C-Peptide Levels) and Circulating Insulin Antibodies

  1979cites this paper
• Use of an artificial pancreas as a tool to determine subcutaneous insulin doses in juvenile diabetes

  1979cites this paper
• PRECURSORS IN THE BIOSYNTHESIS OF INSULIN AND OTHER PEPTIDE HORMONES

  1979cites this paper
• Reference Section for C-peptide Symposium

  1978cites this paper
• A prospective study of glucose tolerance, insulin, C-peptide, and glucagon responses in patients with pancreatic carcinoma

  1978cites this paper
• Identification of the major polyadenylylated transcription products and the genes active in their synthesis in a rat insulinoma.

  1978cites this paper