Musculoskeletal Manifestations of Sickle Cell Disease: A Review

Sickle cell disease (SCD) is an inherited disorder of abnormal haemoglobin commonly encountered in the West African sub-region. It has varied osteoarticular and non-osseous complications that mimic some surgical conditions. The most common orthopaedic complications include avascular necrosis, osteomyelitis, septic arthritis, etc. A cautious and painstaking evaluation is required in handling these patients. Acute care and anaesthetic precautions are vital in ensuring an uneventful postoperative period.

• Publication year

  2015

• Venue

  Cureus

• Publication date

  2015-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.7759/cureus.358PMID 26623213PMCID 4659689
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sickle Cell Anaemia

  2012cited by this paper
• Sickle-cell disease

  2010cited by this paper
• Outcome of management of chronic osteomyelitis at National Orthopaedic Hospital, Enugu.

  2009cited by this paper
• Hydroxyurea for the treatment of sickle cell anemia.

  2008cited by this paper
• Percutaneous Implantation of Autologous Bone Marrow Osteoprogenitor Cells as Treatment of Bone Avascular Necrosis Related to Sickle Cell Disease

  2008cited by this paper
• The natural history of asymptomatic osteonecrosis of the femoral head in adults with sickle cell disease.

  2006cited by this paper
• Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis.

  2005cited by this paper
• Total Hip Arthroplasty in Sickle Cell Hemoglobinopathies

  2005cited by this paper
• Bone involvement in sickle cell disease

  2005cited by this paper
• Chronic Osteomyelitis in Patients Who Have Haemoglobinopathy

  2004cited by this paper
• MRI Follow-Up and Natural History of Avascular Necrosis of the Femoral Head in Kuwaiti Children With Sickle Cell Disease

  2004cited by this paper
• Thrombosis and gangrene in a patient with sickle cell disease and dactylitis.

  2003cited by this paper
• Managing sickle cell disease

  2003cited by this paper
• Therapeutic challenges in childhood sickle cell disease Part 1: current and future treatment options

  2003cited by this paper
• Asymmetrical Closure of Epiphyses in a Patient with Sickle Cell Anemia

  2002cited by this paper
• Chronic leg ulceration in homozygous sickle cell disease: the role of venous incompetence

  2002cited by this paper
• Prevalence, clinical features, and risk factors of osteonecrosis of the femoral head among adults with sickle cell disease.

  2000cited by this paper
• Commentary on and reprint of Pauling L, Itano HA, Singer SJ, Wells IC, Sickle cell anemia, a molecular disease, in Science (1949) 110:543–548

  2000cited by this paper
• Laboratory investigation of hemoglobinopathies and thalassemias: review and update.

  2000cited by this paper
• Major changes in sickle cell disease.

  2000cited by this paper
• Core decompression in avascular necrosis of the hip in sickle‐cell disease

  1996cited by this paper
• Differentiation of bone infarct from infection in a child in sickle cell disease.

  1996cited by this paper
• Sickle cell disease.

  1996cited by this paper
• Total hip arthroplasty in sickle cell hemoglobinopathy.

  1993cited by this paper
• Avascular necrosis of the femoral head in sickle-cell disease. Treatment of collapse by the injection of acrylic cement.

  1993cited by this paper
• Sickle cell disease as a cause of osteonecrosis of the femoral head.

  1991cited by this paper
• Pain in sickle cell disease. Rates and risk factors.

  1991cited by this paper
• Osteomyelitis in children with sickle cell disease: early diagnosis with contrast-enhanced CT.

  1991cited by this paper
• Acute infarction of long bones in children with sickle cell anemia.

  1982cited by this paper
• The treatment of severely ill patients with sickle cell anemia and associated septic arthritis.

  1980cited by this paper
• Sickle cell dactylitis.

  1980cited by this paper
• Sickle-cell anemia: molecular and cellular bases of therapeutic approaches (first of three parts).

  1978cited by this paper
• Management of osteonecrosis in sickle-cell anemia and its genetic variants.

  1978cited by this paper
• Sickle-cell anemia: molecular and cellular bases of therapeutic approaches (second of three parts).

  1978cited by this paper
• Chronic synovitis with early cartilage destruction in sickle cell disease.

  1977cited by this paper
• Joint manifestations of sickle cell disease.

  1974cited by this paper
• Sickle cell anaemia.

  1965cited by this paper
• The handfoot syndrome in sickle-cell disease in young children.

  1963cited by this paper
• A Specific Chemical Difference Between the Globins of Normal Human and Sickle-Cell Anæmia Hæmoglobin

  1956cited by this paper
• Sickle cell anemia a molecular disease.

  1949cited by this paper
• Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia.

  1910influential reference

• Secondary Craniosynostosis in Metabolic and Hematologic Disorders

  2026cites this paper
• Challenges and Management Outcomes of Osteoarticular Infections in Adult Sickle Cell Disease Patients

  2025cites this paper
• Osteomyelitis Complicating Sickle Cell Disease

  2025cites this paper
• Rheumatoid Arthritis in Patients with Sickle Cell Disease: Clinical Challenges and Management Insights from a Case Series in Basrah

  2025cites this paper
• The Vertebral Manifestations of Sickle Cell Disease: A Literature Review

  2025cites this paper
• Osteoarticular Complications of Sickle Cell Disease in Bukavu: A Retrospective Multicenter Cross‐Sectional Study

  2025cites this paper
• Musculoskeletal complications in sickle cell disease: Pathophysiology, diagnosis and management.

  2025cites this paper
• Unmet Need: Mechanistic and Translational Studies of Sickle Cell Disease Pain as a Whole Person Health Challenge.

  2024cites this paper
• Correlation between skeletal manifestations of sickle cell disease (SCD) and transcranial doppler imaging velocities

  2023cites this paper
• Genetic Disorders in Pediatric Rheumatology Clinic: When to Suspect, and Why?

  2023cites this paper
• Radiological manifestation of avascular necrosis (AVN) in sickle cell disease (SCD): a review of diagnostic imaging

  2023cites this paper
• Considerations in the Sickle Cell Patient Undergoing Hip Reconstructive Surgery.

  2022cites this paper
• Sickle Cell Disease Association with Premature Suture Fusion in Young Children

  2022cites this paper
• Neglected tropical rheumatic diseases

  2022cites this paper
• Coexistence of Relapsing Polychondritis and Sickle Cell Disease in a Child

  2021cites this paper
• Haematogenous Osteoarticular Infections in Paediatric Sickle Cell Trait Patients: A Reality in a Tertiary Centre in West Africa

  2021cites this paper
• Forehead Swelling and Fever in a 12-year-old Ugandan Boy

  2021cites this paper
• Fifteen-minute consultation: Recognition of sickle cell crises in the paediatric emergency department

  2021cites this paper
• Knowledge of musculoskeletal complications in sickle cell disease among medical students at King Faisal University

  2021cites this paper
• Analysis of Bone Microarchitectural Changes and Structural Damage in Sickle Cell Disease-Induced Avascular Necrosis Using Raman Spectroscopy

  2021cites this paper
• Systemic complications and imaging challenges of sickle cell disease in sub-saharan Africa

  2021cites this paper
• Musculoskeletal MRI of Nontraumatic Emergencies.

  2020cites this paper
• NSS_A_146608 907..936

  2020influential citation
• Life-Threatening Infectious Complications in Sickle Cell Disease: A Concise Narrative Review

  2020cites this paper
• Comparative screening of anti-sickling reported and traditional herbs found in Chhattisgarh

  2020cites this paper
• Development of Algorithm for Clinical Management of Sickle Cell Bone Disease: Evidence for a Role of Vertebral Fractures in Patient Follow-up

  2020cites this paper
• Leg Length Discrepancies in Nigerian Children with Sickle Cell Anaemia

  2020cites this paper
• Sleep-disordered breathing and comorbidities: role of the upper airway and craniofacial skeleton

  2020cites this paper
• Predictors of musculoskeletal manifestations in paediatric patients presenting with sickle cell disease at a tertiary teaching hospital in Lusaka, Zambia

  2020cites this paper
• Epidemiology and Perioperative Complications in Patients With Sickle Cell Disease After Orthopaedic Surgery: 26 Years' Experience at a Major Academic Center.

  2019cites this paper
• Evaluation of Mandible Fractures in Patients With Sickle Cell Anemia-A Nationwide Study.

  2019cites this paper
• Spinal Manifestations of Systemic Disease.

  2019cites this paper
• Musculoskeletal Faces of Death: A Diagnostic Imaging Review.

  2019cites this paper
• Imaging of Musculoskeletal Manifestations Related to Pediatric Hematologic Diseases

  2019cites this paper
• Hand-foot syndrome (sickle cell disease)

  2018cites this paper
• Pain Management Issues as Part of the Comprehensive Care of Patients with Sickle Cell Disease

  2018cites this paper
• Sickle Cell Disease: Bone, Joint, Muscle, and Motor Complications.

  2018cites this paper
• Orthopaedic Manifestations of Sickle Cell Disease.

  2018cites this paper
• Juvenile arthritis management in less resourced countries (JAMLess): consensus recommendations from the Cradle of Humankind

  2018cites this paper
• Primary Care of Patients with Sickle Cell Disease

  2017cites this paper
• Rheumatoid Arthritis in Sickle-Cell Population: Pathophysiologic Insights, Clinical Evaluation and Management

  2017cites this paper
• Dactylitis: A Complication in Patients With Sickle Cell Disease

  2017cites this paper
• Severely Damaged Hip Joints from Avascular Necrosis in a Patient with Sickle Cell Trait: Case Report

  2017cites this paper
• Mapping Molecular Changes Associated with Avascular Necrosis Using Raman Spectrometry

  2017cites this paper
• Osteomyelitis

  2017cites this paper
• Osteonecrosis in Sickle Cell Disease.

  2016influential citation
• Osteomyelitis

  year unknowncites this paper
• World Journal of Orthopedics

  year unknowninfluential citation