Unglycosylated clusterin variant accumulates in the endoplasmic reticulum and induces cytotoxicity.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  International Journal of Biochemistry and Cell Biology

• Publication date

  2013-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.biocel.2012.11.014PMID 23201481
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer

  2013cited by this paper
• Bax induces activation of the unfolded protein response by inducing HAC1 mRNA splicing in Saccharomyces cerevisiae

  2012cited by this paper
• Abstract 3261: GRP78 regulates clusterin stability, retrotranslocation, and mitochondrial localization under ER stress in prostate cancer

  2012cited by this paper
• The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

  2011cited by this paper
• Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.

  2011cited by this paper
• CRM1 Protein-mediated Regulation of Nuclear Clusterin (nCLU), an Ionizing Radiation-stimulated, Bax-dependent Pro-death Factor*

  2011cited by this paper
• Quality and quantity control at the endoplasmic reticulum.

  2010cited by this paper
• Activation of eukaryotic initiation factor-2 α-kinases in okadaic acid-treated neurons.

  2010cited by this paper
• Targeting the Cytoprotective Chaperone, Clusterin, for Treatment of Advanced Cancer

  2010cited by this paper
• Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration.

  2008cited by this paper
• Stress‐Induced Retrotranslocation of Clusterin/ApoJ into the Cytosol

  2007cited by this paper
• The role of p58IPK in protecting the stressed endoplasmic reticulum.

  2007cited by this paper
• Effects of glycosylation on the structure and function of the extracellular chaperone clusterin.

  2007cited by this paper
• An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.

  2006cited by this paper
• Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway.

  2006cited by this paper
• Clusterin enhances proliferation of primary astrocytes through extracellular signal-regulated kinase activation

  2006cited by this paper
• Clusterin inhibits apoptosis by interacting with activated Bax

  2005cited by this paper
• Role of N-linked polymannose oligosaccharides in targeting glycoproteins for endoplasmic reticulum-associated degradation

  2004cited by this paper
• Alterations in the post-translational modification and intracellular trafficking of clusterin in MCF-7 cells during apoptosis

  2003cited by this paper
• Role of EDEM in the Release of Misfolded Glycoproteins from the Calnexin Cycle

  2003cited by this paper
• Synthesis and Functional Analyses of Nuclear Clusterin, a Cell Death Protein*

  2003cited by this paper
• EDEM As an Acceptor of Terminally Misfolded Glycoproteins Released from Calnexin

  2003cited by this paper
• Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction.

  2002cited by this paper
• Clusterin.

  2002cited by this paper
• Htm1p, a mannosidase‐like protein, is involved in glycoprotein degradation in yeast

  2001cited by this paper
• Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death.

  2000cited by this paper
• Clusterin Has Chaperone-like Activity Similar to That of Small Heat Shock Proteins*

  1999cited by this paper
• Oligosaccharide Modification in the Early Secretory Pathway Directs the Selection of a Misfolded Glycoprotein for Degradation by the Proteasome*

  1999cited by this paper
• Deleterious actions of chronic ethanol treatment on the glycosylation of rat brain clusterin.

  1998cited by this paper
• A transmembrane form of the prion protein in neurodegenerative disease.

  1998cited by this paper
• Stress-induced transcription of the clusterin/apoJ gene.

  1997cited by this paper
• Identification and characterization of glycosylation sites in human serum clusterin

  1997cited by this paper
• Relationship between multifunctional protein "clusterin" and Alzheimer disease.

  1996cited by this paper
• Clusterin (SGP‐2) Induction in Rat Astroglial Cells Exposed to Prion Protein Fragment 106–126

  1996cited by this paper
• Transforming growth factor beta (TGF beta)-induced nuclear localization of apolipoprotein J/clusterin in epithelial cells.

  1996cited by this paper
• Transforming Growth Factor β (TGFβ)-Induced Nuclear Localization of Apolipoprotein J/Clusterin in Epithelial Cells†

  1996cited by this paper
• Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration.

  1994cited by this paper
• Sulfated glycoprotein-2: an emerging molecular marker for neurodegeneration.

  1993cited by this paper
• Sulfated Glycoprotein‐2: An Emerging Molecular Marker for Neurodegeneration

  1993cited by this paper
• Sulfated glycoprotein 2: new relationships of this multifunctional protein to neurodegeneration.

  1992cited by this paper
• Intracellular processing of apolipoprotein J precursor to the mature heterodimer.

  1991cited by this paper
• Molecular cloning and characterization of the novel, human complement‐associated protein, SP‐40,40: a link between the complement and reproductive systems.

  1989cited by this paper
• Purification and characterization of a cell-aggregating factor (clusterin), the major glycoprotein in ram rete testis fluid.

  1983cited by this paper
• Control and manipulation of the phosphodolichol pathway of proteinN-glycosylation

  1982cited by this paper
• Hudson et al.

  1977cited by this paper

• Clusterin ameliorates diabetic atherosclerosis by suppressing macrophage pyroptosis and activation

  2025cites this paper
• Deregulated Clusterin as a Marker of Bone Fragility: New Insights into the Pathophysiology of Osteoporosis

  2022cites this paper
• The Influence of Clusterin Glycosylation Variability on Selected Pathophysiological Processes in the Human Body

  2022influential citation
• Glycosylation Significantly Inhibits the Aggregation of Human Prion Protein and Decreases Its Cytotoxicity

  2018cites this paper
• Altered levels of blood proteins in Alzheimer's disease longitudinal study: Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort

  2017cites this paper
• Clusterin (APOJ) in Alzheimer’s Disease: An Old Molecule with a New Role

  2016cites this paper
• Single octapeptide deletion selectively processes a pathogenic prion protein mutant on the cell surface.

  2016cites this paper
• Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells

  2015cites this paper
• Nucleofection of Rat Pheochromocytoma PC-12 Cells with Human Mutated Beta-Amyloid Precursor Protein Gene (APP-sw) Leads to Reduced Viability, Autophagy-Like Process, and Increased Expression and Secretion of Beta Amyloid

  2015cites this paper
• Distinct promoters, subjected to epigenetic regulation, drive the expression of two clusterin mRNAs in prostate cancer cells.

  2015cites this paper
• Radicicol induces intracellular accumulation of glycan-deficient clusterin variant.

  2015cites this paper
• Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

  2014cites this paper
• Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease

  2014cites this paper
• Specific inhibition of hamster prion protein translocation by the dodecadepsipeptide valinomycin.

  2013cites this paper
• Cotransin induces accumulation of a cytotoxic clusterin variant that cotranslationally rerouted to the cytosol.

  2013cites this paper
• Altered levels of blood proteins in Alzheimer's disease Altered levels of blood proteins in Alzheimer's disease longitudinal study: Results from Australian Imaging Biomarkers longitudinal study: Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort Lifestyle Study of Ageing coh

  year unknowncites this paper