Effects of cysteine-to-serine mutations on structural and functional properties of prostaglandin endoperoxide synthase.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Archives of Biochemistry and Biophysics

• Publication date

  1996-11-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1006/ABBI.1996.0515PMID 8914931
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Design, synthesis, and biochemical evaluation of N-substituted maleimides as inhibitors of prostaglandin endoperoxide synthases.

  1996cited by this paper
• Rapid inactivation of prostaglandin endoperoxide synthases by N-(carboxyalkyl)maleimides.

  1994cited by this paper
• Investigation of the role of cysteines in catalysis by prostaglandin endoperoxide synthase.

  1994cited by this paper
• The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

  1994cited by this paper
• N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum.

  1993cited by this paper
• Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

  1993cited by this paper
• Prostaglandin endoperoxide synthase. The aspirin acetylation region.

  1992cited by this paper
• Expression of prostaglandin endoperoxide synthase-1 in a baculovirus system.

  1992cited by this paper
• Rapid high-efficiency site-directed mutagenesis by the phosphorothioate approach.

  1992cited by this paper
• Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxide synthase.

  1992cited by this paper
• Essential histidines of prostaglandin endoperoxide synthase. His-309 is involved in heme binding.

  1991cited by this paper
• Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis.

  1990cited by this paper
• The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.

  1990cited by this paper
• Concerted loss of cyclooxygenase and peroxidase activities from prostaglandin H synthase upon proteolytic attack.

  1989cited by this paper
• Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities.

  1987cited by this paper
• Rapid and efficient site-specific mutagenesis without phenotypic selection.

  1987cited by this paper
• Rapid and efficient site-specific mutagenesis without phenotypic selection.

  1985cited by this paper
• Spectral properties of the higher oxidation states of prostaglandin H synthase.

  1985cited by this paper
• Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis.

  1980cited by this paper
• Structural characteristics of prostaglandin synthetase from sheep vesicular gland.

  1980cited by this paper
• Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

  1979cited by this paper
• Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands.

  1977cited by this paper
• Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation.

  1974cited by this paper
• On the mechanism of the biosynthesis of prostaglandins E-1 and F-1-alpha.

  1967cited by this paper

• A quantum chemical investigation of energetic, geometric, mechanistic, and kinetic aspects of multiple proton transfer in cyclic H2O, H2S, and H2O‐H2S clusters

  2024cites this paper
• Cumulative impact of classical, weak and sulfur-centered H-bonds on structure and energetic: Homodimers of formic acid and its thio derivatives

  2023cites this paper
• A comparative study of the potential energy surfaces of (CO)2, CO-CS and (CS)2

  2022cites this paper
• Bridging H2O and H2S homomeric clusters via H2O-H2S mixed clusters: Impact of the changing ratio of H2O and H2S moieties

  2022cites this paper
• An Activity-based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells.

  2019cites this paper
• Prostaglandin Synthesis in the Coral Plexaura homomalla : Control of Prostaglandin Stereochemistry at Carbon 15 by Cyclooxygenases

  2007cites this paper
• Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs.

  2004cites this paper
• Animal Model Cysteine 10 Is a Key Residue in Amyloidogenesis of Human Transthyretin Val30Met

  2004cites this paper
• Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases.

  2003cites this paper
• Comparison of the properties of prostaglandin H synthase-1 and -2.

  2003cites this paper
• The origin of 15R-prostaglandins in the Caribbean coral Plexaura homomalla: Molecular cloning and expression of a novel cyclooxygenase

  2001cites this paper