Deficiency of telomerase activity aggravates the blood–brain barrier disruption and neuroinflammatory responses in a model of experimental stroke

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Neuroscience Research

• Publication date

  2010-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jnr.22450PMID 20564349PMCID PMC2919635
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Involvement of ROS in BBB dysfunction

  2009cited by this paper
• Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

  2008cited by this paper
• Transmembrane proteins of tight junctions.

  2008cited by this paper
• Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells.

  2008cited by this paper
• Adhesion and migration of polymorphonuclear leukocytes across human brain microvessel endothelial cells are differentially regulated by endothelial cell adhesion molecules and modulate monolayer permeability.

  2007cited by this paper
• The inflammatory response in stroke.

  2007cited by this paper
• The role of reactive oxygen species in the hearts of dystrophin-deficient mdx mice.

  2007cited by this paper
• The harms and benefits of inflammatory and immune responses in vascular disease.

  2006cited by this paper
• Cerebral ischemia enhances tyrosine phosphorylation of occludin in brain capillaries.

  2006cited by this paper
• Vascular Smooth Muscle Cells Undergo Telomere-Based Senescence in Human Atherosclerosis: Effects of Telomerase and Oxidative Stress

  2006cited by this paper
• Telomere Biology and Cardiovascular Disease

  2006cited by this paper
• H2O2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway.

  2005cited by this paper
• Alcohol‐induced oxidative stress in brain endothelial cells causes blood‐brain barrier dysfunction

  2005cited by this paper
• Telomerase therapeutics for degenerative diseases.

  2005cited by this paper
• Mitochondria, oxidants, and aging.

  2005cited by this paper
• Overexpression of Telomerase Confers Growth Advantage, Stress Resistance, and Enhanced Differentiation of ESCs Toward the Hematopoietic Lineage

  2005cited by this paper
• Telomerase induction in astrocytes of Sprague-Dawley rat after ischemic brain injury.

  2004cited by this paper
• The blood-brain barrier: an overview: structure, regulation, and clinical implications.

  2004cited by this paper
• Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells

  2004cited by this paper
• Gene Expression Profile in Interleukin-4-Stimulated Human Vascular Endothelial Cells

  2004cited by this paper
• Hydrogen peroxide-induced alterations of tight junction proteins in bovine brain microvascular endothelial cells.

  2004influential reference
• Ectopic Expression of the Catalytic Subunit of Telomerase Protects against Brain Injury Resulting from Ischemia and NMDA-Induced Neurotoxicity

  2004influential reference
• Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative Senescence of Endothelial Cells

  2004cited by this paper
• Expression of Telomerase RNA Template, but Not Telomerase Reverse Transcriptase, Is Limiting for Telomere Length Maintenance In Vivo

  2004cited by this paper
• Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells.

  2004cited by this paper
• Hydrogen Peroxide Triggers Nuclear Export of Telomerase Reverse Transcriptase via Src Kinase Family-Dependent Phosphorylation of Tyrosine 707

  2003cited by this paper
• Seizures and tissue injury induce telomerase in hippocampal microglial cells.

  2002cited by this paper
• Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress.

  2002cited by this paper
• Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1.

  2002cited by this paper
• Inflammatory Cell Adhesion Molecules in Ischemic Cerebrovascular Disease

  2002cited by this paper
• Differential regulation of telomerase activity and TERT expression during brain development in mice

  2001cited by this paper
• Emerging roles for telomerase in neuronal development and apoptosis

  2001cited by this paper
• Elements of cerebral microvascular ischaemia.

  2001cited by this paper
• eNOS Activity Is Reduced in Senescent Human Endothelial Cells: Preservation by hTERT Immortalization

  2001cited by this paper
• Hypoxia Extends the Life Span of Vascular Smooth Muscle Cells through Telomerase Activation

  2001cited by this paper
• Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

  2001cited by this paper
• Monochlorobimane fluorometric method to measure tissue glutathione.

  2000cited by this paper
• Multiple domains of occludin are involved in the regulation of paracellular permeability

  2000cited by this paper
• Tight Junctions of the Blood–Brain Barrier

  2000cited by this paper
• Potential Role of Cerebral Glutathione in the Maintenance of Blood-Brain Barrier Integrity in Rat

  1999cited by this paper
• Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

  1998cited by this paper
• Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress.

  1998cited by this paper
• Intrathecal release of pro‐ and anti‐inflammatory cytokines during stroke

  1997influential reference
• Cytoskeletal rearrangement mediates human microvascular endothelial tight junction modulation by cytokines.

  1997cited by this paper
• Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia.

  1996cited by this paper
• Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse.

  1994cited by this paper
• Effect of Brain Edema on Infarct Volume in a Focal Cerebral Ischemia Model in Rats

  1993cited by this paper
• Long-term neurological assessment of the post-resuscitative effects of flunarizine, verapamil and nimodipine in a new model of global complete ischaemia.

  1989cited by this paper

• Molecular and Clinical Considerations for Anesthesia in the Aging Brain

  2025cites this paper
• The association between C-reactive protein-to-lymphocyte ratio and telomere length: A cross-sectional population-based study

  2025cites this paper
• Aging, vascular dysfunction, and the blood–brain barrier: unveiling the pathophysiology of stroke in older adults

  2025cites this paper
• Electroacupuncture Ameliorates Neuronal Damage and Neurological Deficits after Cerebral Ischemia-Reperfusion Injury via Restoring Telomerase Reverse Transcriptase

  2024cites this paper
• Age-Related Alterations in Immune Function and Inflammation: Focus on Ischemic Stroke

  2023influential citation
• Electroacupuncture pretreatment preserves telomerase reverse transcriptase function and alleviates postoperative cognitive dysfunction by suppressing oxidative stress and neuroinflammation in aged mice

  2023cites this paper
• Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage

  2022cites this paper
• External environmental agents influence telomere length and telomerase activity by modulating internal cellular processes: Implications in human aging.

  2021cites this paper
• Melatonin Reduces Neuroinflammation and Improves Axonal Hypomyelination by Modulating M1/M2 Microglia Polarization via JAK2-STAT3-Telomerase Pathway in Postnatal Rats Exposed to Lipopolysaccharide

  2021cites this paper
• Accelerated Biologic Aging, Chronic Stress, and Risk for Sepsis and Organ Failure Following Trauma.

  2020cites this paper
• Telomeres in neurological disorders.

  2019cites this paper
• RETRACTED: Cerebellar fastigial nucleus electrical stimulatin protects against cerebral ischemic damage by upregulating telomerase activity

  2019cites this paper
• Mood Disorders, Accelerated Aging, and Inflammation: Is the Link Hidden in Telomeres?

  2019cites this paper
• The telomere length of peripheral blood cells is associated with the risk of ischemic stroke in Han population of northern China

  2019cites this paper
• Telomere length and advanced diffusion MRI as biomarkers for repetitive mild traumatic brain injury in adolescent rats

  2018cites this paper
• The Emerging Roles for Telomerase in the Central Nervous System

  2018cites this paper
• TLR 4 Signaling is Involved in Brain Vascular Toxicity of PCB 153 Bound to Nanoparticles

  2017cites this paper
• Polymorphisms in Telomere Length Associated TERC and TERT predispose for Ischemic Stroke in a Chinese Han population

  2017cites this paper
• Charting the perfect storm: emerging biological interfaces between stress and stroke

  2017cites this paper
• Antiretroviral Treatment with Efavirenz Disrupts the Blood-Brain Barrier Integrity and Increases Stroke Severity

  2016cites this paper
• Does telomerase protein protect our neurons

  2016cites this paper
• Excitotoxic and Radiation Stress Increase TERT Levels in the Mitochondria and Cytosol of Cerebellar Purkinje Neurons

  2016cites this paper
• University of Groningen Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening

  2015cites this paper
• Enhanced microglial pro‐inflammatory response to lipopolysaccharide correlates with brain infiltration and blood–brain barrier dysregulation in a mouse model of telomere shortening

  2015influential citation
• Telomere Biology in Senescence and Aging

  2014cites this paper
• Inflammation, advancing age and nutrition

  2014cites this paper
• Umbilical cord blood mesenchymal stem cells co‐modified by TERT and BDNF: A novel neuroprotective therapy for neonatal hypoxic‐ischemic brain damage

  2014influential citation
• Correction: TLR4 Signaling Is Involved in Brain Vascular Toxicity of PCB153 Bound to Nanoparticles

  2014cites this paper
• MULTIFACTORIAL MODULATION OF THE BLOOD-BRAIN BARRIER: RELATIONSHIP TO STROKE

  2013cites this paper
• TLR4 Signaling Is Involved in Brain Vascular Toxicity of PCB153 Bound to Nanoparticles

  2013cites this paper
• Novel experimental model for repeated forebrain ischemia-reperfusion

  2012cites this paper
• Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis

  2012cites this paper
• Cerebrovascular Toxicity of PCB153 is Enhanced by Binding to Silica Nanoparticles

  2012cites this paper
• Telomere Shortening and Alzheimer’s Disease

  2012cites this paper
• Cerebrovascular Disorders: Role of Aging

  2012cites this paper
• Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective

  2011cites this paper
• Telomerase expression on aortic wall endothelial cells is attenuated in abdominal aortic aneurysms compared to healthy nonaneurysmal aortas.

  2011cites this paper
• Telomerase reverse transcriptase: A novel neuroprotective mechanism involved in neonatal hypoxic‐ischemic brain injury

  2011cites this paper
• Non-telomeric activities of telomerase.

  2011cites this paper
• eview elomerase reverse transcriptase : A novel neuroprotective mechanism involved n neonatal hypoxic-ischemic brain injury

  2011cites this paper
• Healthy aging and disease: role for telomere biology?

  2011cites this paper