Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2010-01-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.0914856107PMID 20133758PMCID PMC2823912
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Translation of intronless RNAs is strongly stimulated by the Epstein–Barr virus mRNA export factor EB2

  2009cited by this paper
• Cyclin-dependent Kinases Phosphorylate the Cytomegalovirus RNA Export Protein pUL69 and Modulate Its Nuclear Localization and Activity*

  2009influential reference
• eIF4E: New Family Members, New Binding Partners, New Roles*

  2009cited by this paper
• Cytomegaloviral protein kinase pUL97 interacts with the nuclear mRNA export factor pUL69 to modulate its intranuclear localization and activity.

  2009cited by this paper
• Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex.

  2008cited by this paper
• The many roles of the regulatory protein ICP27 during herpes simplex virus infection.

  2008influential reference
• Herpes Simplex Virus ICP27 Increases Translation of a Subset of Viral Late mRNAs

  2008cited by this paper
• Human Cytomegalovirus UL97 Kinase Activity Is Required for the Hyperphosphorylation of Retinoblastoma Protein and Inhibits the Formation of Nuclear Aggresomes

  2008cited by this paper
• Phosphorylation of Retinoblastoma Protein by Viral Protein with Cyclin-Dependent Kinase Function

  2008cited by this paper
• Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs.

  2008cited by this paper
• Manifestations of human cytomegalovirus infection: proposed mechanisms of acute and chronic disease.

  2008cited by this paper
• Multimerization of human cytomegalovirus regulatory protein UL69 via a domain that is conserved within its herpesvirus homologues.

  2007cited by this paper
• Interferon-induced Mx proteins in antiviral host defense.

  2007cited by this paper
• Human cytomegalovirus pUL37x1 induces the release of endoplasmic reticulum calcium stores

  2006cited by this paper
• The UL69 Transactivator Protein of Human Cytomegalovirus Interacts with DEXD/H-Box RNA Helicase UAP56 To Promote Cytoplasmic Accumulation of Unspliced RNA

  2006influential reference
• RNA-binding of the human cytomegalovirus transactivator protein UL69, mediated by arginine-rich motifs, is not required for nuclear export of unspliced RNA

  2006cited by this paper
• Evidence that Poly(A) Binding Protein C1 Binds Nuclear Pre-mRNA Poly(A) Tails

  2006cited by this paper
• Direct Stimulation of Translation by the Multifunctional Herpesvirus ICP27 Protein

  2006cited by this paper
• Human Cytomegalovirus UL131 Open Reading Frame Is Required for Epithelial Cell Tropism

  2005cited by this paper
• Control of VP16 Translation by the Herpes Simplex Virus Type 1 Immediate-Early Protein ICP27

  2005cited by this paper
• Epstein-Barr Virus mRNA Export Factor EB2 Is Essential for Intranuclear Capsid Assembly and Production of gp350

  2005cited by this paper
• Regulation of the Translation Initiation Factor eIF4F by Multiple Mechanisms in Human Cytomegalovirus-Infected Cells

  2005cited by this paper
• The Evolutionarily Conserved Kaposi's Sarcoma-associated Herpesvirus ORF57 Protein Interacts with REF Protein and Acts as an RNA Export Factor*

  2004cited by this paper
• Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells.

  2004cited by this paper
• Human Cytomegalovirus Infection Induces Rapamycin-Insensitive Phosphorylation of Downstream Effectors of mTOR Kinase

  2004cited by this paper
• Proteomics of herpes simplex virus infected cell protein 27: association with translation initiation factors.

  2004cited by this paper
• Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB

  2004cited by this paper
• Human Cytomegalovirus UL99-Encoded pp28 Is Required for the Cytoplasmic Envelopment of Tegument-Associated Capsids

  2003cited by this paper
• Regulation of translation initiation by FRAP/mTOR.

  2001cited by this paper
• Altered Cellular mRNA Levels in Human Cytomegalovirus-Infected Fibroblasts: Viral Block to the Accumulation of Antiviral mRNAs

  2001cited by this paper
• A novel transferable nuclear export signal mediates CRM1‐independent nucleocytoplasmic shuttling of the human cytomegalovirus transactivator protein pUL69

  2001cited by this paper
• Human cytomegalovirus UL69 protein is required for efficient accumulation of infected cells in the G1 phase of the cell cycle.

  2000influential reference
• Nuclear Eukaryotic Initiation Factor 4e (Eif4e) Colocalizes with Splicing Factors in Speckles

  2000cited by this paper
• Functional Interaction between Pleiotropic Transactivator pUL69 of Human Cytomegalovirus and the Human Homolog of Yeast Chromatin Regulatory Protein SPT6

  2000influential reference
• Human Cytomegalovirus UL69 Protein Induces Cells To Accumulate in G1 Phase of the Cell Cycle

  1999influential reference
• The Human Poly(A)-binding Protein 1 Shuttles between the Nucleus and the Cytoplasm*

  1998cited by this paper
• Translational controls impinging on the 5'-untranslated region and initiation factor proteins.

  1997cited by this paper
• A specific subform of the human cytomegalovirus transactivator protein pUL69 is contained within the tegument of virus particles

  1996cited by this paper
• The yeast two-hybrid system for studying protein-protein interactions.

  1995cited by this paper
• Human cytomegalovirus IE1 and IE2 proteins block apoptosis

  1995influential reference
• UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transactivator of gene expression

  1994cited by this paper
• A novel genetic system to detect protein–protein interactions

  1989cited by this paper
• Characterization of monoclonal antibodies and polyclonal immune sera directed against human cytomegalovirus virion proteins.

  1984cited by this paper
• Candidate cytomegalovirus strain for human vaccination

  1975cited by this paper
• On a messenger ribonucleoprotein complex from rabbit reticulocytes.

  1969cited by this paper

• RNA-targeted proteomics identifies YBX1 as critical for efficient HCMV mRNA translation

  2025cites this paper
• A autophagy related gene signature to predict the prognosis of pancreatic carcinoma and tumor immune microenvironment evaluation

  2025cites this paper
• Viral interference of nucleocytoplasmic transport

  2025cites this paper
• Proximity-dependent mapping of the HCMV US28 interactome identifies RhoGEF signaling as a requirement for efficient viral reactivation

  2023cites this paper
• Insights into the Transcriptome of Human Cytomegalovirus: A Comprehensive Review

  2023influential citation
• When Poly(A) Binding Proteins Meet Viral Infections, Including SARS-CoV-2

  2022cites this paper
• Identification of UL69 Gene and Protein in Cytomegalovirus-Transformed Human Mammary Epithelial Cells

  2021cites this paper
• Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E

  2020cites this paper
• Human Cytomegalovirus Primary Infection and Reactivation: Insights From Virion-Carried Molecules

  2020cites this paper
• Eukaryotic initiation factor 4A (eIF4A) during viral infections

  2019cites this paper
• Interferon-Independent Innate Responses to Cytomegalovirus

  2019cites this paper
• Human cytomegalovirus induces and exploits Roquin to counteract the IRF1-mediated antiviral state

  2019cites this paper
• Host-Virus Protein Interaction Network Reveals the Involvement of Multiple Host Processes in the Life Cycle of Hepatitis E Virus

  2018cites this paper
• Bovine adenovirus‐3 protein VIII associates with eukaryotic initiation factor‐6 during infection

  2018cites this paper
• Dengue Virus Selectively Annexes Endoplasmic Reticulum-Associated Translation Machinery as a Strategy for Co-opting Host Cell Protein Synthesis

  2018cites this paper
• The ICP27 Homology Domain of the Human Cytomegalovirus Protein UL69 Adopts a Dimer-of-Dimers Structure

  2018cites this paper
• Battling for Ribosomes: Translational Control at the Forefront of the Antiviral Response.

  2018cites this paper
• Epstein-Barr Virus Protein EB2 Stimulates Translation Initiation of mRNAs through Direct Interactions with both Poly(A)-Binding Protein and Eukaryotic Initiation Factor 4G

  2017cites this paper
• Rôle de la protéine EB2 du virus d'Epstein-Barr dans le métabolisme des ARN messagers

  2016cites this paper
• HIV-1 Gag Blocks Selenite-Induced Stress Granule Assembly by Altering the mRNA Cap-Binding Complex

  2016cites this paper
• An unbiased proteomics approach to identify human cytomegalovirus RNA-associated proteins.

  2015cites this paper
• EIF4EBP1 Overexpression Is Associated with Poor Survival and Disease Progression in Patients with Hepatocellular Carcinoma

  2015cites this paper
• TRANSLATION REGULATION DURING HCMV INFECTION

  2015cites this paper
• Modulation of the Translational Landscape During Herpesvirus Infection.

  2015cites this paper
• Functional annotation of human cytomegalovirus gene products: an update

  2014cites this paper
• Functional annotation of human cytomegalovirus gene products: an update

  2014cites this paper
• Tinkering with translation: protein synthesis in virus-infected cells.

  2013cites this paper
• Over‐expression of human cytomegalovirus miR‐US25‐2‐3p downregulates eIF4A1 and inhibits HCMV replication

  2013cites this paper
• Differential Role for Host Translation Factors in Host and Viral Protein Synthesis during Human Cytomegalovirus Infection

  2013cites this paper
• A new role for the cellular PABP repressor Paip2 as an innate restriction factor capable of limiting productive cytomegalovirus replication

  2013cites this paper
• CMV Late Phase‐Induced mTOR Activation Is Essential for Efficient Virus Replication in Polarized Human Macrophages

  2012cites this paper
• Recruitment of host translation initiation factor eIF4G by the Vaccinia Virus ssDNA-binding protein I3.

  2012cites this paper
• Viral modulation of stress granules

  2012cites this paper
• Poly(A) binding protein abundance regulates eukaryotic translation initiation factor 4F assembly in human cytomegalovirus-infected cells

  2012cites this paper
• The many roles of the highly interactive HSV protein ICP27, a key regulator of infection.

  2011cites this paper
• Hepatitis C Virus NS5A Binds to the mRNA Cap-binding Eukaryotic Translation Initiation 4F (eIF4F) Complex and Up-regulates Host Translation Initiation Machinery through eIF4E-binding Protein 1 Inactivation*

  2011cites this paper
• The Cellular Protein SPT6 Is Required for Efficient Replication of Human Cytomegalovirus

  2011cites this paper
• The Changing Role of mTOR Kinase in the Maintenance of Protein Synthesis during Human Cytomegalovirus Infection

  2011cites this paper
• Cap and cap‐binding proteins in the control of gene expression

  2011cites this paper
• Viral subversion of the host protein synthesis machinery

  2011cites this paper
• Manipulation of the host translation initiation complex eIF4F by DNA viruses.

  2010cites this paper
• Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAs

  2010cites this paper
• Binding of the Human Cytomegalovirus (HCMV) Tegument Protein UL69 to UAP56/URH49 Is Not Required for Efficient Replication of HCMV

  2010cites this paper
• Characterization of the Betaherpesviral pUL69 Protein Family Reveals Binding of the Cellular mRNA Export Factor UAP56 as a Prerequisite for Stimulation of Nuclear mRNA Export and for Efficient Viral Replication

  2010cites this paper