The CAG repeat polymorphism of the androgen receptor gene and breast cancer

BackgroundGenetic variants in hormone receptor genes may be crucial predisposing factors for breast cancer, and microsatellites in the androgen receptor gene (AR) have been suggested to play a role. The aim of the study was to determine the association between the length of the CAG repeats in the AR gene and the development of breast cancer. Methodology: In total, 75 breast cancer cases and 50 healthy controls were analyzed for CAG repeats in the AR gene by polymerase chain reaction and the GeneScan/Genotyping technique.ResultsCAG repeat genotypes and alleles distribution were found to be significantly different between breast cancer patients and controls (P < 0.05). While the presence of CAG repeats shorter than 22 (classified as short, S) increases the risk of breast cancer, the risk is reduced by the presence of CAG repeats longer than 22. In the group of patients with breast cancer, a high tumor stage was found to have a significant association with genotype S/S of CAG repeats in the AR gene.ConclusionOur results suggest that the length of CAG repeats in the androgen receptor gene is associated with the risk of developing breast cancer.

• Publication year

  2014

• Venue

  Central European Journal of Biology

• Publication date

  2014-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2478/s11535-014-0325-y
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Triple-negative breast cancer : molecular characteristics and potential therapeutic approaches

  2013cited by this paper
• [Triple-negative breast cancer: molecular characteristics and potential therapeutic approaches].

  2013cited by this paper
• Nowotwory w Polsce w 2012 roku

  2013cited by this paper
• Association of the CAG repeat polymorphisms in androgen receptor gene with polycystic ovary syndrome: a systemic review and meta-analysis.

  2013cited by this paper
• Androgen receptor polyglutamine repeat number: models of selection and disease susceptibility

  2012cited by this paper
• Microsatellites in the Estrogen Receptor (ESR1, ESR2) and Androgen Receptor (AR) Genes and Breast Cancer Risk in African American and Nigerian Women

  2012cited by this paper
• Minireview: The androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?

  2012cited by this paper
• Androgen Receptor Expression and Breast Cancer Survival in Postmenopausal Women

  2011cited by this paper
• Selected estrogen receptor 1 and androgen receptor gene polymorphisms in relation to risk of breast cancer and fibrocystic breast conditions among Chinese women.

  2011cited by this paper
• CAG repeat length polymorphism in the androgen receptor gene and breast cancer risk: data on Indian women and survey from the world

  2011cited by this paper
• Role of the androgen receptor CAG repeat polymorphism in prostate cancer, and spinal and bulbar muscular atrophy.

  2011cited by this paper
• Androgen Receptor Gene CAG Repeat Polymorphism and Breast Cancer Risk in Iranian Women: A Case‐Control Study

  2011cited by this paper
• Expression of androgen receptors in primary breast cancer.

  2010cited by this paper
• Androgen receptor status predicts response to chemotherapy, not risk of breast cancer in Indian women

  2010cited by this paper
• Polymorphisms in genes of the steroid receptor superfamily modify postmenopausal breast cancer risk associated with menopausal hormone therapy

  2010cited by this paper
• Triple-Negative Breast Cancer: Role of the Androgen Receptor

  2010cited by this paper
• Association between androgen receptor gene CAG repeat polymorphism and breast cancer risk: a meta-analysis

  2010cited by this paper
• Urine Accurately Reflects Circulating Isoflavonoids and Ascertains Compliance During Soy Intervention

  2010cited by this paper
• Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer.

  2008cited by this paper
• Androgen receptor expresion in breast cancer: Relationship with clinicopathological characteristics of the tumors, prognosis, and expression of metalloproteases and their inhibitors

  2008cited by this paper
• Androgen receptor gene CAG repeats, estrogen exposure status, and breast cancer susceptibility

  2008cited by this paper
• The role of the polyglutamine tract in androgen receptor.

  2008cited by this paper
• Associations between Androgen and Vitamin D Receptor Microsatellites and Postmenopausal Breast Cancer

  2007cited by this paper
• ESR1, AR, body size, and breast cancer risk in Hispanic and non-Hispanic white women living in the Southwestern United States

  2007cited by this paper
• Increased risk of breast cancer in women bearing a combination of large CAG and GGN repeats in the exon 1 of the androgen receptor gene.

  2007cited by this paper
• Androgens and breast cancer.

  2006cited by this paper
• Combined profile of the tandem repeats CAG, TA and CA of the androgen and estrogen receptor genes in breast cancer

  2006cited by this paper
• Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases

  2005cited by this paper
• Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition.

  2005cited by this paper
• Androgen Receptor and Prostate-Specific Antigen Gene Polymorphisms and Breast Cancer in African-American Women

  2005cited by this paper
• Age-specific sensitivities of mammographic screening for breast cancer

  2005cited by this paper
• Shorter CAG repeat length in the androgen receptor gene is associated with more aggressive forms of breast cancer

  2004cited by this paper
• The androgen receptor CAG repeat polymorphism and modification of breast cancer risk in BRCA1 and BRCA2 mutation carriers

  2004cited by this paper
• Androgen Receptor Gene Alterations in Finnish Male Breast Cancer

  2004cited by this paper
• Androgen receptor (CAG)n and (GGC)n polymorphisms and breast cancer risk in a population-based case-control study of young women.

  2003cited by this paper
• Androgen receptor CAG repeat length in Jewish Israeli women who are BRCA1/2 mutation carriers: association with breast/ovarian cancer phenotype

  2002cited by this paper
• Androgen receptor status in female breast cancer: RT-PCR and Western blot studies

  2002cited by this paper
• The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study.

  2002cited by this paper
• High frequency of skewed X inactivation in young breast cancer patients

  2002cited by this paper
• Lack of association between androgen receptor CAG polymorphism and familial breast/ovarian cancer.

  2001cited by this paper
• Short polyglutamine tracts in the androgen receptor are protective against breast cancer in the general population.

  2001cited by this paper
• CAG and GGC repeat polymorphisms in the androgen receptor gene and breast cancer susceptibility in BRCA1/2 carriers and non-carriers

  2001cited by this paper
• The polymorphic CAG repeat of the androgen receptor gene: a potential role in breast cancer in women over 40

  2001cited by this paper
• Androgens and androgen receptor: do they play a role in breast cancer?

  2000cited by this paper
• RNA metabolism in the cortex of newly weaned rats following first exposure to light

  1973cited by this paper
• The anionotropic rearrangement of a steroidal ethynyl-ethylenic alcohol

  1964cited by this paper
• EFFECT OF CORTICOSTEROIDS ON RIBONUCLEASE AND NUCLEIC ACID CONTENT IN LYMPHOSARCOMA P1798.

  1963cited by this paper
• of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)

  year unknowncited by this paper

• No citing papers are available for this paper.