Mutation of orthologous prickle genes causes a similar epilepsy syndrome in flies and humans

Genetically tractable fruit flies have been used for decades to study seizure disorders. However, there is a paucity of data specifically correlating fly and human seizure phenotypes. We have previously shown that mutation of orthologous PRICKLE genes from flies to humans produce seizures. This study aimed to determine whether the prickle‐mediated seizure phenotypes in flies closely parallel the epilepsy syndrome found in PRICKLE patients.

• Publication year

  2016

• Venue

  Annals of Clinical and Translational Neurology

• Publication date

  2016-08-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/acn3.334PMID 27648459PMCID 5018582
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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