Pseudo-Replication of [GADV]-Proteins and Origin of Life

The RNA world hypothesis on the origin of life is generally considered as the key to solve the “chicken and egg dilemma” concerning the evolution of genes and proteins as observed in the modern organisms. This hypothesis, however, contains several serious weak points. We have a counterproposal called [GADV]-protein world hypothesis, abbreviated as GADV hypothesis, in which we have suggested that life originated from a [GADV]-protein world, which comprised proteins composed of four amino acids: Gly [G], Ala [A], Asp [D], and Val [V]. A new concept “pseudo-replication” is crucial for the description of the emergence of life. The new hypothesis not only plausibly explains how life originated from the initial chaotic protein world, but also how genes, genetic code, and proteins co-evolved.

• Publication year

  2009

• Venue

  International Journal of Molecular Sciences

• Publication date

  2009-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/ijms10041525PMID 19468323PMCID 2680631
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Formal Proof that the Split Genes of tRNAs of Nanoarchaeum equitans Are an Ancestral Character

  2009cited by this paper
• The split genes of Nanoarchaeum equitans are an ancestral character.

  2008cited by this paper
• The structure of a TNA-TNA complex in solution: NMR study of the octamer duplex derived from alpha-(L)-threofuranosyl-(3'-2')-CGAATTCG.

  2008cited by this paper
• The origin of genes could be polyphyletic.

  2008cited by this paper
• Modelling evolution on design-by-contract predicts an origin of Life through an abiotic double-stranded RNA world

  2007cited by this paper
• Modelling evolution on design-by-contract predicts an origin of Life through an abiotic double-stranded RNA world

  2007cited by this paper
• Peptide Nucleic Acids and the Origin of Life

  2007cited by this paper
• Mechanisms for Creation of "Original Ancestor Genes"

  2005cited by this paper
• Stirring the primordial soup

  2005cited by this paper
• Possible steps to the emergence of life: the [GADV]-protein world hypothesis.

  2005influential reference
• Catalytic Activities Of [GADV]-Peptides

  2005cited by this paper
• Catalytic activities of [GADV]-peptides. Formation and establishment of [GADV]-protein world for the emergence of life.

  2005cited by this paper
• TNA synthesis by DNA polymerases.

  2003cited by this paper
• A Novel Theory on the Origin of the Genetic Code: A GNC-SNS Hypothesis

  2002influential reference
• Determination of Organic Compounds Formed in Simulated Interstellar Dust Environment

  2002cited by this paper
• Origins of gene, genetic code, protein and life: comprehensive view of life systems from a GNC-SNS primitive genetic code hypothesis

  2002influential reference
• Chemical Etiology of Nucleic Acid Structure: The α-Threofuranosyl-(3'→2') Oligonucleotide System

  2000cited by this paper
• A Simpler Nucleic Acid

  2000cited by this paper
• Methyl-RNA: an evolutionary bridge between RNA and DNA?

  2000cited by this paper
• Chemical etiology of nucleic acid structure: the alpha-threofuranosyl-(3'-->2') oligonucleotide system.

  2000cited by this paper
• A Search for Extraterrestrial Amino Acids in Carbonaceous Antarctic Micrometeorites

  1998cited by this paper
• Amino acid synthesis from an amorphous substance composed of carbon, nitrogen, and oxygen

  1998cited by this paper
• A possible origin of newly-born bacterial genes: significance of GC-rich nonstop frame on antisense strand.

  1996influential reference
• Specific aminoacylation of C4N hairpin RNAs with the cognate aminoacyl-adenylates in the presence of a dipeptide: origin of the genetic code.

  1995cited by this paper
• The origin of life on the earth.

  1994cited by this paper
• A global view.

  1994cited by this paper
• Peptide nucleic acids (PNA) : oligonucleotide analogues with an achiral peptide backbone

  1992cited by this paper
• RNA world

  1987cited by this paper
• Origin of life: The RNA world

  1986cited by this paper
• [The origin of life on this earth].

  1985cited by this paper
• Theoretical and experimental approach to recognition of amino acid by tRNA.

  1983cited by this paper
• The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme.

  1983cited by this paper
• Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena.

  1982cited by this paper
• The Origins of Life on the Earth

  1974cited by this paper
• Prebiotic synthesis of hydrophobic and protein amino acids.

  1972cited by this paper
• Evolution by Gene Duplication

  1970cited by this paper
• A production of amino acids under possible primitive earth conditions.

  1953cited by this paper
• THE ORIGIN OF LIFE

  1912cited by this paper

• Chemical Evolution of Life on Earth

  2025cites this paper
• Role of metal(ii) hexacyanocobaltate(iii) surface chemistry for prebiotic peptides synthesis

  2025cites this paper
• Origin of Type II tRNA Variable Loops, Aminoacyl-tRNA Synthetase Allostery from Distal Determinants, and Diversification of Life

  2024cites this paper
• The 3 31 Nucleotide Minihelix tRNA Evolution Theorem and the Origin of Life

  2023cites this paper
• A crescendo of competent coding (c3) contains the Standard Genetic Code

  2022cites this paper
• How Did Life Emerge in Chemically Complex Messy Environments?

  2022cites this paper
• The Origin of Protein

  2021cites this paper
• The Origin of Life

  2021cites this paper
• Evolution of the genetic code

  2021cites this paper
• Prebiotic Peptides Based on the Glycocodon Theory Analyzed with FRET

  2021cites this paper
• Introduction

  2021cites this paper
• Theoretical Analysis of S, M and N Structural Proteins by the Protein–RNA Recognition Code Leads to Genes/proteins that Are Relevant to the SARS-CoV-2 Life Cycle and Pathogenesis

  2021cites this paper
• The Origin of Cell Structure

  2021cites this paper
• A Few Experimental Suggestions Using Minerals to Obtain Peptides with a High Concentration of L-Amino Acids and Protein Amino Acids

  2020cites this paper
• Chaos, Order and Systematics in Evolution of the Genetic Code

  2020influential citation
• Bibliography

  2020cites this paper
• 1 Protein 0 th-Order Structure : The Key for Creating 2 Entirely New Gene / Protein 3

  2019cites this paper
• A Non-paradoxical Pathway for the Chemical Evolution Toward the Most Primitive RNA-Based Life-like System

  2019cites this paper
• Hypothesen zur molekularen Evolution

  2019cites this paper
• One Step up the Ladder of Prebiotic Complexity: Formation of Nonrandom Linear Polypeptides from Binary Systems of Amino Acids on Silica.

  2019cites this paper
• The Origin of tRNA Deduced from Pseudomonas aeruginosa 5′ Anticodon-Stem Sequence

  2019cites this paper
• Under what kind of life system could space life emerge?

  2019cites this paper
• Life emerged as the “ protein / metabolism-first ” theory 2 expects 3 4

  2018cites this paper
• THE DYNAMICS OF THE LIVING

  2017cites this paper
• A Proposal of the Ur-proteome

  2017cites this paper
• GADV-protein: An alternative to RNA in the origin of life

  2017cites this paper
• Catalysis in the Primordial World

  2017cites this paper
• Evolutionary Steps in the Emergence of Life Deduced from the Bottom-Up Approach and GADV Hypothesis (Top-Down Approach)

  2016influential citation
• Formation of Diastereoisomeric Piperazine-2,5-dione from dl-Alanine in the Presence of Olivine and Water

  2016cites this paper
• Self-assembly behaviours of primitive and modern lipid membrane solutions: a coarse-grained molecular simulation study.

  2016cites this paper
• GADV Hypothesis on the Origin of Life

  2016cites this paper
• Predicting Three-Dimensional Conformations of Peptides Constructed of Only Glycine, Alanine, Aspartic Acid, and Valine

  2015influential citation
• A History of Genomic Structures: The Big Picture

  2015cites this paper
• [GADV]-Protein World Hypothesis on the Origin of Life

  2014cites this paper
• Protein Ordered Sequences are Formed by Random Joining of Amino Acids in Protein 0th-Order Structure, Followed by Evolutionary Process

  2014cites this paper
• Two Perspectives on the Origin of the Standard Genetic Code

  2014cites this paper
• Uniquely Localized Intra-Molecular Amino Acid Concentrations at the Glycolytic Enzyme Catalytic/Active Centers of Archaea, Bacteria and Eukaryota are Associated with Their Proposed Temporal Appearances on Earth

  2013cites this paper
• 生命の起源におけるタンパク質ワールド仮説に登場する [GADV]-タンパク質のスレッディングおよびab initioモデリングによる立体構造推定

  2013cites this paper
• Estimated Abundances of a Precursor of Glycine, CH 3 NH 2

  2013cites this paper
• NGC 6334-V : Near-Infrared Circular Polarization Images of NGC 6334-V: Implication for Astrobiol-ogy

  2013cites this paper
• Abiotic Formation of Valine Peptides Under Conditions of High Temperature and High Pressure

  2012cites this paper
• Reality of the Emergence of Life-Like Systems from Simple Prebiotic Polymers on Primitive Earth

  2012cites this paper
• Origin of the Genetic Code and Genetic Disorder

  2011cites this paper
• Catalytic peptide hydrolysis by mineral surface: Implications for prebiotic chemistry

  2010cites this paper
• Proteome Evolution and the Metabolic Origins of Translation and Cellular Life

  2010cites this paper
• Editorial: hypotheses about protein folding - the proteomic code and wonderfolds

  2009cites this paper
• PROTEIN 0 TH -ORDER STRUCTURES AND THE ORIGIN OF LIFE

  2009cites this paper
• Hipotezy o powstaniu i wczesnej ewolucji życia

  2009cites this paper