The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces changes in the heme spin state of microsomal cytochrome P-450.

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Biochemistry International

• Publication date

  1990-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 1965943
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Parkinson's disease and cytochrome P450: a possible link?

  1990cited by this paper
• Depression of the hepatic cytochrome P-450 monooxygenase system by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

  1989cited by this paper
• Quantitative analysis of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolism in isolated rat hepatocytes.

  1988cited by this paper
• Interaction of stanozolol with cytochrome P-450.

  1988cited by this paper
• Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

  1988cited by this paper
• MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation.

  1987cited by this paper
• Studies on the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine cytotoxicity in isolated hepatocytes.

  1987cited by this paper
• Contribution of N-oxygenation to the metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by various liver preparations.

  1986cited by this paper
• Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine.

  1985cited by this paper
• Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

  1985cited by this paper
• Permanent human parkinsonism due to 1‐methy 1–4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)

  1985cited by this paper
• Metabolism of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by liver homogenate fractions.

  1985cited by this paper
• Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey.

  1984cited by this paper
• A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

  1983cited by this paper
• Formation and binding of carbanions by cytochrome P-450 of liver microsomes.

  1973cited by this paper
• Ligand interactions with cytochrome P-450. I. Binding of primary amines.

  1969cited by this paper
• Spectral studies of drug interaction with hepatic microsomal cytochrome.

  1967cited by this paper
• EPR measurements of substrate interaction with cytochrome P-450.

  1966cited by this paper
• THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

  1964cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Pharmacogenetic considerations in the treatment of co-infections with HIV/AIDS, tuberculosis and malaria in Congolese populations of Central Africa.

  2020cites this paper
• Resveratrol potentiates cytochrome P450 2 d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse.

  2012cites this paper
• Award Number: W81XWH-11-1-0150 TITLE: Protection by Purines in Toxin Models of Parkinson's Disease PRINCIPAL INVESTIGATOR:

  2012cites this paper
• Nicotine and caffeine-mediated modulation in the expression of toxicant responsive genes and vesicular monoamine transporter-2 in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype in mouse.

  2008cites this paper
• Stereospecific prevention by 17β‐estradiol of MPTP‐induced dopamine depletion in mice

  2000cites this paper
• Novel sites of action for deprenyl in MPTP-parkinsonism: metabolite-mediated protection against striatal neurotoxicity and suppression of MPTP-induced increase of dopamine turnover in C57BL mice.

  1995cites this paper
• Debrisoquine 4-monooxygenase and bufuralol 1'-monooxygenase activities in bovine and rabbit tissues.

  1992cites this paper