In vivo studies of transdermal nanoparticle delivery with microneedles using photoacoustic microscopy.

Microneedle technology allows micron-sized conduits to be formed within the outermost skin layers for both localized and systemic delivery of therapeutics including nanoparticles. Histological methods are often employed for characterization, and unfortunately do not allow for the in vivo visualization of the delivery process. This study presents the utilization of optical resolution-photoacoustic microscopy to characterize the transdermal delivery of nanoparticles using microneedles. Specifically, we observe the in vivo transdermal delivery of gold nanoparticles using microneedles in mice ear and study the penetration, diffusion, and spatial distribution of the nanoparticles in the tissue. The promising results reveal that photoacoustic microscopy can be used as a potential imaging modality for the in vivo characterization of microneedles based drug delivery.

• Publication year

  2017

• Venue

  Biomedical Optics Express

• Publication date

  2017-12-01

• Fields of study

  Medicine, Materials Science, Engineering

• Identifiers
  DOI 10.1364/BOE.8.005483PMID 29296482PMCID PMC5745097
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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