Hyperphosphorylation of Mouse Cardiac Titin Contributes to Transverse Aortic Constriction-Induced Diastolic Dysfunction

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Circulation Research

• Publication date

  2011-09-30

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1161/CIRCRESAHA.111.246819PMID 21835910PMCID PMC3191198
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Exercise training does not improve cardiac function in compensated or decompensated left ventricular hypertrophy induced by aortic stenosis.

  2011cited by this paper
• Contribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle.

  2011cited by this paper
• The effects of PKCalpha phosphorylation on the extensibility of titin's PEVK element.

  2010cited by this paper
• Cardiac titin: a multifunctional giant.

  2010cited by this paper
• Transverse aortic constriction in mice.

  2010cited by this paper
• Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development.

  2010cited by this paper
• Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness.

  2010cited by this paper
• Treatment of heart failure with normal ejection fraction: an inconvenient truth!

  2010cited by this paper
• Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload.

  2009cited by this paper
• PKC Phosphorylation of Titin’s PEVK Element: A Novel and Conserved Pathway for Modulating Myocardial Stiffness

  2009cited by this paper
• Pressure Overload–Induced Alterations in Fibrillar Collagen Content and Myocardial Diastolic Function: Role of Secreted Protein Acidic and Rich in Cysteine (SPARC) in Post–Synthetic Procollagen Processing

  2009cited by this paper
• Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload

  2009cited by this paper
• Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence.

  2009cited by this paper
• Truncation of Titin’s Elastic PEVK Region Leads to Cardiomyopathy With Diastolic Dysfunction

  2009cited by this paper
• Hypophosphorylation of the Stiff N2B Titin Isoform Raises Cardiomyocyte Resting Tension in Failing Human Myocardium

  2009cited by this paper
• Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs

  2008cited by this paper
• Myofilament dysfunction in cardiac disease from mice to men

  2008cited by this paper
• Augmented Protein Kinase C-α–Induced Myofilament Protein Phosphorylation Contributes to Myofilament Dysfunction in Experimental Congestive Heart Failure

  2007cited by this paper
• Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy

  2007cited by this paper
• New molecular mechanism in diastolic heart failure.

  2006cited by this paper
• Trends in prevalence and outcome of heart failure with preserved ejection fraction.

  2006cited by this paper
• CARMA: A platform for analyzing microarray datasets that incorporate replicate measures

  2006cited by this paper
• Systolic and diastolic heart failure in the community.

  2006cited by this paper
• Oxygen, oxidative stress, hypoxia, and heart failure.

  2005cited by this paper
• Phosphorylation of Titin Modulates Passive Stiffness of Cardiac Muscle in a Titin Isoform-dependent Manner

  2005cited by this paper
• Diastolic heart failure: definitions and terminology.

  2005cited by this paper
• Heart Failure: A Companion to Braunwald's Heart Disease

  2005cited by this paper
• Altered Titin Expression, Myocardial Stiffness, and Left Ventricular Function in Patients With Dilated Cardiomyopathy

  2004cited by this paper
• What Mechanisms Underlie Diastolic Dysfunction in Heart Failure?

  2004cited by this paper
• Impact of beta-myosin heavy chain expression on cardiac function during stress.

  2004cited by this paper
• Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle.

  2004cited by this paper
• Developmental Control of Titin Isoform Expression and Passive Stiffness in Fetal and Neonatal Myocardium

  2004cited by this paper
• Passive Stiffness Changes Caused by Upregulation of Compliant Titin Isoforms in Human Dilated Cardiomyopathy Hearts

  2004cited by this paper
• Titin isoform expression in normal and hypertensive myocardium.

  2003cited by this paper
• Doppler evaluation of peripheral vascular adaptations to transverse aortic banding in mice.

  2003cited by this paper
• Changes in Titin Isoform Expression in Pacing-Induced Cardiac Failure Give Rise to Increased Passive Muscle Stiffness

  2002cited by this paper
• Echocardiographic assessment of LV hypertrophy and function in aortic-banded mice: necropsy validation.

  2002cited by this paper
• Protein Kinase A Phosphorylates Titin’s Cardiac-Specific N2B Domain and Reduces Passive Tension in Rat Cardiac Myocytes

  2002cited by this paper
• Titin Isoform Switch in Ischemic Human Heart Disease

  2002cited by this paper
• Cardiac titin isoforms are coexpressed in the half-sarcomere and extend independently.

  2001cited by this paper
• Extensibility of isoforms of cardiac titin: variation in contour length of molecular subsegments provides a basis for cellular passive stiffness diversity.

  2000cited by this paper
• Changes in titin and collagen underlie diastolic stiffness diversity of cardiac muscle.

  2000cited by this paper
• Determination of left ventricular chamber stiffness from the time for deceleration of early left ventricular filling.

  1995cited by this paper
• Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments.

  1995cited by this paper
• The influence of basic residues on the substrate specificity of protein kinase C.

  1987cited by this paper

• Discovery of Titin and Its Role in Heart Function and Disease.

  2025cites this paper
• Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility

  2025cites this paper
• Titin is a new factor regulating arterial stiffness through vascular smooth muscle cell tone in male rats

  2025cites this paper
• Titin: roles in cardiac function and diseases

  2024cites this paper
• Congenital Titinopathies Linked to Mutations in TTN Metatranscript-Only Exons

  2024cites this paper
• Role of Titin Phosphorylation in Myocardial Stiffness Changes during Cardiomyopathies

  2024influential citation
• Late-life Rapamycin Treatment Enhances Cardiomyocyte Relaxation Kinetics and Reduces Myocardial Stiffness

  2023cites this paper
• Proteomics and phosphoproteomics of failing human left ventricle identifies dilated cardiomyopathy-associated phosphorylation of CTNNA3

  2023cites this paper
• Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice

  2022cites this paper
• The thromboxane receptor antagonist NTP42 promotes beneficial adaptation and preserves cardiac function in experimental models of right heart overload

  2022cites this paper
• Assessing systolic and diastolic reserves in male and female mice.

  2022cites this paper
• Efficacy of a Growth Hormone-Releasing Hormone Agonist in a Murine Model of Cardiometabolic Heart Failure with Preserved Ejection Fraction

  2022cites this paper
• The Cardiomyocyte in Heart Failure with Preserved Ejection Fraction—Victim of Its Environment?

  2022cites this paper
• Adolescent Binge Alcohol Exposure Effects on Heart Structure and Function

  2021cites this paper
• Myofilament Phosphorylation in Stem Cell Treated Diastolic Heart Failure

  2021cites this paper
• Increased Expression of N2BA Titin Corresponds to More Compliant Myofibrils in Athlete’s Heart

  2021influential citation
• Investigation into the protective effects of hypaconitine and glycyrrhetinic acid against chronic heart failure of the rats

  2021cites this paper
• Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart☆

  2020cites this paper
• The importance of an integrated genotype-phenotype strategy to unravel the molecular bases of titinopathies.

  2020cites this paper
• Binge Alcohol Exposure in Adolescence Impairs Normal Heart Growth

  2020cites this paper
• A new congenital multicore titinopathy associated with fast myosin heavy chain deficiency

  2020cites this paper
• Compliant Titin Isoform Content Is Reduced in Left Ventricles of Sedentary Versus Active Rats

  2020cites this paper
• Mechanisms Underlying Cardiovascular Benefits of Sodium Glucose Co-Transporter-2 Inhibitors: Myocardial Substrate or Sodium/Hydrogen Exchanger?

  2020cites this paper
• Global Proteomics and Phosphoproteomics of Heart Failure Patients Elucidate Etiology-Specific Signaling

  2019cites this paper
• Posttranslational modifications of titin from cardiac muscle: how, where, and what for?

  2019cites this paper
• [Why Myocardial Relaxation Always Slows at Cardiac Pathology?]

  2019cites this paper
• Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis

  2018cites this paper
• Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance

  2018cites this paper
• Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes

  2018cites this paper
• Characterization of TTN Novex Splicing Variants across Species and the Role of RBM20 in Novex-Specific Exon Splicing

  2018cites this paper
• RBM20, a potential target for treatment of cardiomyopathy via titin isoform switching

  2018cites this paper
• Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B

  2018cites this paper
• Human heart failure with preserved ejection versus feline cardiomyopathy: what can we learn from both veterinary and human medicine?

  2017cites this paper
• Residual force enhancement is regulated by titin in skeletal and cardiac myofibrils

  2017cites this paper
• Effect of exercise on passive myocardial stiffness in mice with diastolic dysfunction.

  2017cites this paper
• &agr;-B Crystallin Reverses High Diastolic Stiffness of Failing Human Cardiomyocytes

  2017cites this paper
• Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes

  2017cites this paper
• Targeting acetaldehyde dehydrogenase 2 (ALDH2) in heart failure-Recent insights and perspectives.

  2017cites this paper
• diomyocyte stiffness as a consequence to functional modifications of the sarcomeric protein titin. By folding during contraction and stretching during relaxation, titin

  2017cites this paper
• Renin Overexpression Leads to Increased Titin‐Based Stiffness Contributing to Diastolic Dysfunction in Hypertensive mRen2 Rats

  2016cites this paper
• Sarcomeric accumula 1 on of α-B Crystallin reverses high diastolic s 1 ffness of failing human cardiomyocytes by Constan 1 jn

  2016cites this paper
• Heart failure with preserved ejection fraction.

  2016cites this paper
• Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn).

  2016cites this paper
• Prolonged controlled mechanical ventilation in humans triggers myofibrillar contractile dysfunction and myofilament protein loss in the diaphragm

  2016cites this paper
• Proteomics Analysis Revealed an Altered Left Ventricle Protein Profile in a Mouse Model of Transverse Aortic Constriction.

  2016cites this paper
• Posttranslational Modification of the Titin Springs: Dynamic Adaptation of Passive Sarcomere Stiffness

  2015cites this paper
• Syndromestiffening of muscle fibers in Ehlers-Danlos

  2015cites this paper
• Right ventricular diastolic dysfunction in pulmonary arterial hypertension

  2015cites this paper
• Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling.

  2015cites this paper
• Myocardial hypertrophy and its role in heart failure with preserved ejection fraction.

  2015cites this paper
• Exploring New Concepts in the Management of Heart Failure with Preserved Ejection Fraction : Is Exercise the Key for Improving Treatment ? Myocardial hypertrophy and its role in heart failure with preserved ejection fraction

  2015cites this paper
• Cardiac Cytoarchitecture

  2015cites this paper
• Effect of exercise training on post-translational and post-transcriptional regulation of titin stiffness in striated muscle of wild type and IG KO mice.

  2014cites this paper
• Cardiac Titin and Heart Disease

  2014cites this paper
• Gigantic Business: Titin Properties and Function Through Thick and Thin

  2014cites this paper
• Protein Changes Contributing to Right Ventricular Cardiomyocyte Diastolic Dysfunction in Pulmonary Arterial Hypertension

  2014cites this paper
• Acute exercise modifies titin phosphorylation and increases cardiac myofilament stiffness

  2014cites this paper
• Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium.

  2014cites this paper
• Endurance training minimizes age-related changes of left ventricular twist-untwist mechanics.

  2014cites this paper
• The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.

  2013cites this paper
• Identification of novel sarcomeric modifiers of hypertrophy in hypertrophic cardiomyopathy using the yeast two-hybrid system

  2013influential citation
• Implication du cytosquelette dans les dysfonctions myocardiques : exemple de la cardiomyopathie septique

  2013cites this paper
• Mechanisms modulating skeletal muscle phenotype.

  2013cites this paper
• Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts.

  2013cites this paper
• Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy

  2013cites this paper
• Crucial Role for Ca2+/Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

  2013cites this paper
• Myocardial titin and collagen in cardiac diastolic dysfunction: partners in crime.

  2013cites this paper
• Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.

  2013influential citation
• Tuning the molecular giant titin through phosphorylation: role in health and disease.

  2013cites this paper
• Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction.

  2013cites this paper
• Titin is a major human disease gene.

  2013cites this paper
• Circulation Research Thematic Synopsis: Heart Failure, Cardiac Hypertrophy, and Ventricular Remodeling

  2012cites this paper
• Characterising the myocardial interstitial space: the clinical relevance of non-invasive imaging

  2012cites this paper
• Heart Failure with Preserved Ejection Fraction

  2012cites this paper
• Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome.

  2012cites this paper
• Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

  2012cites this paper
• Impaired mtDNA replication precedes mtDNA depletion in pressure overload-induced cardiac hypertrophy and heart failure

  2009cites this paper
• See Clinical Perspective

  year unknowncites this paper