Dose Finding – A Challenge in Statistics

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Biometrical journal. Biometrische Zeitschrift

• Publication date

  2008-08-01

• Fields of study

  Mathematics, Medicine, Computer Science

• Identifiers
  DOI 10.1002/bimj.200810438PMID 18663758
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Assessment and Propagation of Model Uncertainty

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• MCPMod: An R Package for the Design and Analysis of Dose-Finding Studies

  2009influential reference
• Optimal Designs for Dose-Finding Studies

  2008cited by this paper
• Multiple Comparisons Procedures

  2008cited by this paper
• Multiple Comparison Procedures in Linear Models

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• Adaptive Dunnett tests for treatment selection

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• Simultaneous Inference in General Parametric Models

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• Statistical Methods for Dose-Finding Experiments

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• A method for therapeutic dose selection in a phase II clinical trial using contrast statistics

  2007cited by this paper
• Generalized nonlinear models in R.

  2007cited by this paper
• Innovative Approaches for Designing and Analyzing Adaptive Dose-Ranging Trials

  2007influential reference
• Optimal Designs for Estimating the Interesting Part of a Dose-Effect Curve

  2007cited by this paper
• Statistical Methods for Dose-Finding Experiments: Chevret/Statistical Methods for Dose-Finding Experiments

  2006cited by this paper
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  2006cited by this paper
• Design and Analysis of Dose-Finding Studies Combining Multiple Comparisons and Modeling Procedures

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  2006cited by this paper
• Confirmatory Seamless Phase II/III Clinical Trials with Hypotheses Selection at Interim: Applications and Practical Considerations

  2006cited by this paper
• Hypothesis Testing and Bayesian Estimation using a Sigmoid E max Model Applied to Sparse Dose-Response Designs

  2006cited by this paper
• Analysis of Dose–Response Studies—Modeling Approaches

  2006cited by this paper
• Dose Response: Pharmacokinetic–Pharmacodynamic Approach

  2006cited by this paper
• Dose Finding in Drug Development

  2006cited by this paper
• Pharmacometrics Applications in Population Exposure–Response Data for New Drug Development and Evaluation

  2006cited by this paper
• Dose Optimization in Drug Development

  2006cited by this paper
• Combining Multiple Comparisons and Modeling Techniques in Dose‐Response Studies

  2005influential reference
• Testing and estimation in flexible group sequential designs with adaptive treatment selection

  2005cited by this paper
• Nonlinear Regression: Seber/Nonlinear Regression

  2005cited by this paper
• A Practical Comparison of Group-Sequential and Adaptive Designs

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  2004cited by this paper
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• Comparison of Methods for the Computation of Multivariate t Probabilities

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• Adaptive Bayesian Designs for Dose-Ranging Drug Trials

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• Generalized Linear Models

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• Adaptive Modifications of Hypotheses After an Interim Analysis

  2001cited by this paper
• Local Regression and Likelihood

  2001cited by this paper
• SAS® System for Regression

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• Group Sequential Methods with Applications to Clinical Trials

  2001cited by this paper
• Adaptive Group Sequential Designs for Clinical Trials: Combining the Advantages of Adaptive and of Classical Group Sequential Approaches

  2001cited by this paper
• Combining different phases in the development of medical treatments within a single trial.

  1999cited by this paper
• Stepwise Confidence Intervals without Multiplicity Adjustment for Dose—Response and Toxicity Studies

  1999cited by this paper
• Local Regression and Likelihood

  1999cited by this paper
• Adaptive Sample Size Calculations in Group Sequential Trials

  1999cited by this paper
• The discovery of penicillin.

  1996cited by this paper
• Model uncertainty, data mining and statistical inference

  1995cited by this paper
• Dose response studies. I. Some design considerations.

  1995influential reference
• Dose response studies. II. Analysis and interpretation.

  1995influential reference
• Designed extension of studies based on conditional power.

  1995cited by this paper
• Dose response studies. II. Analysis and interpretation.

  1995cited by this paper
• Computer Intensive Statistical Methods: Validation, Model Selection, and Bootstrap

  1995cited by this paper
• Computer Intensive Statistical Methods: Validation Model Selection and Bootstrap.

  1994cited by this paper
• Evaluation of experiments with adaptive interim analyses.

  1994cited by this paper
• Handbook of Nonlinear Regression Models

  1991cited by this paper
• Nonlinear Regression Analysis and Its Applications

  1988cited by this paper
• Order restricted statistical inference

  1988cited by this paper
• On Confidence Sets in Multiple Comparisons

  1988cited by this paper
• Qualitative Dosis-Wirkungs-Analysen.

  1987cited by this paper
• Testing the statistical certainty of a response to increasing doses of a drug.

  1985cited by this paper
• On closed testing procedures with special reference to ordered analysis of variance

  1976cited by this paper
• PARACELSUS.

  1964cited by this paper
• A Multiple Comparison Procedure for Comparing Several Treatments with a Control

  1955cited by this paper
• THE DISCOVERY of penicillin.

  1955cited by this paper

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• Maximum tolerable daily dose of mirror movement therapy ankle exercises after stroke: an early phase dose screening study.

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• Dose-dependent effect of carbohydrate restriction for type 2 diabetes management: a systematic review and dose-response meta-analysis of randomized controlled trials.

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• Opportunity for efficiency in clinical development: An overview of adaptive clinical trial designs and innovative machine learning tools, with examples from the cardiovascular field.

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  2018cites this paper
• Optimal designs for frequentist model averaging.

  2018cites this paper
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• Assessing the similarity of dose response and target doses in two non‐overlapping subgroups

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• Good Practices in Model‐Informed Drug Discovery and Development: Practice, Application, and Documentation

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  2016cites this paper
• SFB 823 Assessing the similarity of dose response and target doses in two non-overlapping subgroups D iscussion P aper

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• Sequential design for binary dose–response experiments

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• Intracoronary Adenosine: Dose-Response Relationship With Hyperemia.

  2015cites this paper
• Testing effect of a drug using multiple nested models for the dose–response

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• Dose response signal detection under model uncertainty

  2015influential citation
• Sex differences in risk-taking and associative learning in rats

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• Model selection versus model averaging in dose finding studies

  2015cites this paper
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• Dose-Finding Trials: Optimizing Phase 2 Data in the Drug Development Process.

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• Multiple comparisons in complex clinical trial designs

  2013influential citation
• Two-Stage Experimental Design for Dose-Response Modeling in Toxicology Studies.

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• Dose-response and finding in phase II clinical studies — MCP-Mod Methodologies

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