Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Molecular Biology

• Publication date

  2007-11-02

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.JMB.2007.08.001PMID 17870086
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA Repair and Mutagenesis

  2006cited by this paper
• Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide.

  2005cited by this paper
• Characterization of Caenorhabditis elegans exonuclease-3 and evidence that a Mg2+-dependent variant exhibits a distinct mode of action on damaged DNA.

  2005cited by this paper
• APE1 is the major 3'-phosphoglycolate activity in human cell extracts.

  2004cited by this paper
• AP endonuclease-independent DNA base excision repair in human cells.

  2004cited by this paper
• Mutations in the α8 Loop of Human APE1 Alter Binding and Cleavage of DNA Containing an Abasic Site*

  2003cited by this paper
• A quantitative model of human DNA base excision repair. I. Mechanistic insights.

  2002cited by this paper
• An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3′ mispaired DNA

  2002cited by this paper
• Dynamics and diversions in base excision DNA repair of oxidized abasic lesions

  2002cited by this paper
• Choreography of oxidative damage repair in mammalian genomes.

  2002cited by this paper
• Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

  2002cited by this paper
• Human endonuclease III acts preferentially on DNA damage opposite guanine residues in DNA.

  2001cited by this paper
• Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair.

  2001cited by this paper
• Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step.

  2001cited by this paper
• Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism.

  2001cited by this paper
• Characterization of uracil-DNA glycosylase activity from Trypanosoma cruzi and its stimulation by AP endonuclease.

  2001cited by this paper
• Nuclear DNA polymerase beta from Leishmania infantum. Cloning, molecular analysis and developmental regulation.

  2001cited by this paper
• Apurinic Endonuclease Activity of Yeast Apn2 Protein*

  2000cited by this paper
• Mapping the protein-DNA interface and the metal-binding site of the major human apurinic/apyrimidinic endonuclease.

  2000cited by this paper
• DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination

  2000cited by this paper
• The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis.

  2000cited by this paper
• A Novel Action of Human Apurinic/Apyrimidinic Endonuclease

  2000cited by this paper
• Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.

  2000cited by this paper
• DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected].

  2000cited by this paper
• The role of Mg2+ and specific amino acid residues in the catalytic reaction of the major human abasic endonuclease: new insights from EDTA-resistant incision of acyclic abasic site analogs and site-directed mutagenesis.

  1999cited by this paper
• The Fidelity of DNA Polymerase β during Distributive and Processive DNA Synthesis*

  1999cited by this paper
• Molecular Cloning of the Human Gene, PNKP, Encoding a Polynucleotide Kinase 3′-Phosphatase and Evidence for Its Role in Repair of DNA Strand Breaks Caused by Oxidative Damage*

  1999cited by this paper
• Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coli.

  1999cited by this paper
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  1999cited by this paper
• Initiation of base excision repair: glycosylase mechanisms and structures.

  1999cited by this paper
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  1999cited by this paper
• Induction of an AP endonuclease activity in Streptococcus mutans during growth at low pH

  1999cited by this paper
• Dynamics of the Interaction of Human Apurinic Endonuclease (Ape1) with Its Substrate and Product*

  1998cited by this paper
• Rapid Dissociation of Human Apurinic Endonuclease (Ape1) from Incised DNA Induced by Magnesium*

  1998cited by this paper
• The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra‐helical deoxyribose at DNA abasic sites

  1997cited by this paper
• An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.

  1997cited by this paper
• Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III.

  1997cited by this paper
• Characterization of Escherichia coli Endonuclease VIII*

  1997cited by this paper
• MOLREP: an Automated Program for Molecular Replacement

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• DNA glycosylases in the base excision repair of DNA.

  1997cited by this paper
• 3'-phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends.

  1997cited by this paper
• Refinement of macromolecular structures by the maximum-likelihood method.

  1997cited by this paper
• 3'- and 5'-strand cleavage reactions catalyzed by the Fpg protein from Escherichia coli occur via successive beta- and delta-elimination mechanisms, respectively.

  1996cited by this paper
• Reconstitution of DNA base excision‐repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

  1996cited by this paper
• Site-directed mutagenesis of the human DNA repair enzyme HAP1: identification of residues important for AP endonuclease and RNase H activity.

  1995cited by this paper
• Structure and function of the multifunctional DNA-repair enzyme exonuclease III

  1995cited by this paper
• Characterization of the Promoter Region of the Human Apurinic Endonuclease Gene (APE) (*)

  1995cited by this paper
• Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1

  1995cited by this paper
• Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair.

  1995cited by this paper
• The base excision repair pathway.

  1995cited by this paper
• Raster3D Version 2.0. A program for photorealistic molecular graphics.

  1994cited by this paper
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994cited by this paper
• Repair of oxidative damage to DNA: enzymology and biology.

  1994cited by this paper
• Removal of 3'-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1.

  1994cited by this paper
• PROCHECK: a program to check the stereochemical quality of protein structures

  1993cited by this paper
• Human HeLa cell enzymes that remove phosphoglycolate 3'-end groups from DNA.

  1992cited by this paper
• cDNA cloning, sequencing, expression and possible domain structure of human APEX nuclease homologous to Escherichia coli exonuclease III.

  1992cited by this paper
• Two distinct human DNA diesterases that hydrolyze 3'-blocking deoxyribose fragments from oxidized DNA.

  1991cited by this paper
• Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

  1991cited by this paper
• Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants.

  1991cited by this paper
• Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.

  1991cited by this paper
• Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV.

  1990cited by this paper
• Sensitivity of parasites to free radical damage by antiparasitic drugs.

  1990cited by this paper
• The enzymology of apurinic/apyrimidinic endonucleases.

  1990cited by this paper
• Multiple DNA repair activities for 3'-deoxyribose fragments in Escherichia coli.

  1989cited by this paper
• The relative importance of Escherichia coli exonuclease III and endonuclease IV for the hydrolysis of 3'-phosphoglycolate ends in polydeoxynucleotides.

  1988cited by this paper
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  1987cited by this paper
• Mutagenesis by apurinic/apyrimidinic sites.

  1986cited by this paper
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  1979cited by this paper
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  1963cited by this paper

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  2021cites this paper
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  2020cites this paper
• Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori

  2018cites this paper
• The overexpression of TcAP1 endonuclease confers resistance to infective Trypanosoma cruzi trypomastigotes against oxidative DNA damage

  2018cites this paper
• DSFL database: A hub of target proteins of Leishmania sp. to combat leishmaniasis

  2017cites this paper
• Functional complementation of Leishmania (Leishmania) amazonensis AP endonuclease gene (lamap) in Escherichia coli mutant strains challenged with DNA damage agents

  2016cites this paper
• The major Arabidopsis thaliana apurinic/apyrimidinic endonuclease, ARP is involved in the plant nucleotide incision repair pathway.

  2016cites this paper
• Design and activity of AP endonuclease-1 inhibitors

  2015cites this paper
• Rôles de la recombinaison homologue dans la résistance aux drogues chez le parasite "Leishmania"

  2015influential citation
• Critical determinants for substrate recognition and catalysis in the M. tuberculosis class II AP-endonuclease/3'-5' exonuclease III.

  2015cites this paper
• The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite

  2014cites this paper
• DNA Repair Pathways in Trypanosomatids: from DNA Repair to Drug Resistance

  2014influential citation
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  2012cites this paper
• Trypanosoma brucei AP endonuclease 1 has a major role in the repair of abasic sites and protection against DNA-damaging agents.

  2012cites this paper
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  2011cites this paper
• The Hus1 homologue of Leishmania major encodes a nuclear protein that participates in DNA damage response.

  2011cites this paper
• Crystal structure analysis of DNA uridine endonuclease Mth212 bound to DNA.

  2010cites this paper
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  2010cites this paper
• Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major

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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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