DNA promoter hypermethylation contributes to down-regulation of galactocerebrosidase gene in lung and head and neck cancers.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  International Journal of Clinical and Experimental Pathology

• Publication date

  2015-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 26617822PMCID PMC4637637
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation

  2013cited by this paper
• A novel homozygous GALC mutation: very early onset and rapidly progressive Krabbe disease.

  2013cited by this paper
• Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes.

  2013cited by this paper
• Glycosphingolipids: synthesis and functions

  2013cited by this paper
• Galactosylceramide Affects Tumorigenic and Metastatic Properties of Breast Cancer Cells as an Anti-Apoptotic Molecule

  2013cited by this paper
• Missense mutation in mouse GALC mimics human gene defect and offers new insights into Krabbe disease.

  2013cited by this paper
• Four novel GALC gene mutations in two Chinese patients with Krabbe disease.

  2013cited by this paper
• Structural snapshots illustrate the catalytic cycle of β-galactocerebrosidase, the defective enzyme in Krabbe disease

  2013cited by this paper
• Role of Neurofilament Light Polypeptide in Head and Neck Cancer Chemoresistance

  2012cited by this paper
• DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells.

  2012cited by this paper
• GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response.

  2011cited by this paper
• Insights into Krabbe disease from structures of galactocerebrosidase

  2011cited by this paper
• GALC Deletions Increase the Risk of Primary Open-Angle Glaucoma: The Role of Mendelian Variants in Complex Disease

  2011cited by this paper
• Identification and Characterization of 15 Novel GALC Gene Mutations Causing Krabbe Disease

  2010cited by this paper
• Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines

  2009cited by this paper
• Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

  2008cited by this paper
• Epigenetics of cancer progression.

  2008cited by this paper
• LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer.

  2007cited by this paper
• Ceramide and other sphingolipids in cellular responses

  2007cited by this paper
• Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins.

  2005cited by this paper
• Loss of 14q31-q32.2 in renal cell carcinoma is associated with high malignancy grade and poor survival.

  2004cited by this paper
• Ceramide synthesis and metabolism as a target for cancer therapy.

  2004cited by this paper
• Epigenetics in lung cancer: focus on progression and early lesions.

  2004cited by this paper
• Globoid Cell Leukodystrophy (Krabbe's Disease): Update

  2003cited by this paper
• Glycosphingolipid‐dependent cross‐talk between glycosynapses interfacing tumor cells with their host cells: essential basis to define tumor malignancy

  2002cited by this paper
• Transcriptional repression of the human galactocerebrosidase gene in squamous cell carcinomas of the larynx

  1999cited by this paper
• Loss of heterozygosity at D14S62 and metastatic potential of breast cancer.

  1999cited by this paper
• Loss of heterozygosity on chromosome 14 in primary nasopharyngeal carcinoma.

  1997cited by this paper
• Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism.

  1996cited by this paper
• [Glycolipids of the cell surface--biochemistry of their decomposition].

  1995cited by this paper
• Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.

  1994cited by this paper
• Functional role of glycosphingolipids in tumor progression.

  1992cited by this paper
• The twitcher mouse: accumulation of galactosylsphingosine and pathology of the sciatic nerve.

  1988cited by this paper
• The twitcher mouse: degeneration of oligodendrocytes in vitro.

  1986cited by this paper
• A review of the immunogenic and immuno-modulatory properties of glycosphingolipids.

  1984cited by this paper
• Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.

  1981cited by this paper

• Beyond Krabbe disease, the intriguing connection of galactocerebrosidase (GALC) with nervous system illness: A novel risk factor?

  2025cites this paper
• Sphingolipid Metabolism in Tumor Cells

  2023cites this paper
• Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis

  2023cites this paper
• Integration of Multi-Omics Data to Identify Cancer Biomarkers

  2022cites this paper
• Changes in Sphingolipid Profile of Benzo[a]pyrene-Transformed Human Bronchial Epithelial Cells Are Reflected in the Altered Composition of Sphingolipids in Their Exosomes

  2021cites this paper
• Oncosuppressive and oncogenic activity of the sphingolipid-metabolizing enzyme β-galactosylceramidase.

  2021cites this paper
• Longitudinal transcriptomic and genetic landscape of radiotherapy response in canine melanoma.

  2019cites this paper
• Epithelial-mesenchymal transition and GALC expression of circulating tumor cells indicate metastasis and poor prognosis in non-small cell lung cancer

  2018cites this paper
• Biological Roles of Aberrantly Expressed Glycosphingolipids and Related Enzymes in Human Cancer Development and Progression

  2018influential citation
• Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance

  2018cites this paper
• Sperm membrane proteins associated with the boar semen cryopreservation.

  2017cites this paper
• Correction: Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer

  2017cites this paper
• Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer

  2017cites this paper