Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampus

Long‐term potentiation (LTP) at hippocampal CA3–CA1 synapses is thought to be mediated, at least in part, by an increase in the postsynaptic surface expression of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole proprionic acid (AMPA) receptors induced by N‐methyl‐d‐aspartate (NMDA) receptor activation. While this process was originally attributed to the regulated synaptic insertion of GluA1 (GluR‐A) subunit‐containing AMPA receptors, recent evidence suggests that regulated synaptic trafficking of GluA2 subunits might also contribute to one or several phases of potentiation. However, it has so far been difficult to separate these two mechanisms experimentally. Here we used genetically modified mice lacking the GluA1 subunit (Gria1−/− mice) to investigate GluA1‐independent mechanisms of LTP at CA3–CA1 synapses in transverse hippocampal slices. An extracellular, paired theta‐burst stimulation paradigm induced a robust GluA1‐independent form of LTP lacking the early, rapidly decaying component characteristic of LTP in wild‐type mice. This GluA1‐independent form of LTP was attenuated by inhibitors of neuronal nitric oxide synthase and protein kinase C (PKC), two enzymes known to regulate GluA2 surface expression. Furthermore, the induction of GluA1‐independent potentiation required the activation of GluN2B (NR2B) subunit‐containing NMDA receptors. Our findings support and extend the evidence that LTP at hippocampal CA3–CA1 synapses comprises a rapidly decaying, GluA1‐dependent component and a more sustained, GluA1‐independent component, induced and expressed via a separate mechanism involving GluN2B‐containing NMDA receptors, neuronal nitric oxide synthase and PKC.

• Publication year

  2009

• Venue

  European Journal of Neuroscience

• Publication date

  2009-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1460-9568.2009.06677.xPMID 19302150PMCID 2695863
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• Induction of GluA1-independent potentiation required GluN2B-containing NMDA receptors.

  Confidence 0.95

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• Neuronal nitric oxide synthase and protein kinase C inhibitors attenuated GluA1-independent LTP.

  Confidence 0.93

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• The GluA1-independent LTP lacked the early, rapidly decaying component seen in wild-type mice.

  Confidence 0.92

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• Paired theta-burst stimulation induced robust GluA1-independent LTP at CA3-CA1 synapses in Gria1−/− mice.

  Confidence 0.98

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review

• ca3-ca1 synapses

  synapse

  Hippocampal synaptic connections from CA3 pyramidal neurons to CA1 pyramidal neurons used for the LTP experiments.

  Aliases: hippocampal CA3-CA1 synapses

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• glua1 (glur-a) subunit

  protein subunit

  An AMPA receptor subunit that is absent in the knockout mice used here for testing GluA1-dependent mechanisms.

  Aliases: GluR-A

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• glua1-independent ltp

  synaptic plasticity

  A form of hippocampal synaptic potentiation that can be expressed without the GluA1 AMPA receptor subunit.

  Aliases: GluA1-independent long-term potentiation

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• glun2b-containing nmda receptors

  receptor

  NMDA receptors that include the GluN2B subunit and participate in the induction pathway studied here.

  Aliases: NR2B-containing NMDA receptors

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• gria1−/− mice

  animal model

  Genetically modified mice lacking the Gria1 gene encoding the GluA1 AMPA receptor subunit.

  Aliases: GluA1 knockout mice

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• neuronal nitric oxide synthase

  enzyme

  A nitric-oxide-producing enzyme tested here with pharmacological inhibitors for involvement in synaptic potentiation.

  Aliases: nNOS

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• paired theta-burst stimulation

  stimulation protocol

  An extracellular stimulation protocol that delivers paired theta-pattern bursts to trigger synaptic plasticity.

  Aliases: paired TBS

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• protein kinase c

  enzyme

  A kinase family examined here with inhibitors as a potential regulator of synaptic potentiation.

  Aliases: PKC

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• wild-type mice

  animal model

  Unmodified mice used as the reference genotype for comparison with the Gria1−/− animals.

  Aliases: WT mice

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review

• A nomenclature for ligand-gated ion channels.

  2009cited by this paper
• Calmodulin-kinases: modulators of neuronal development and plasticity.

  2008influential reference
• Postsynaptic Action Potentials Are Required for Nitric-Oxide-Dependent Long-Term Potentiation in CA1 Neurons of Adult GluR1 Knock-Out and Wild-Type Mice

  2008cited by this paper
• PKMζ Maintains Late Long-Term Potentiation by N-Ethylmaleimide-Sensitive Factor/GluR2-Dependent Trafficking of Postsynaptic AMPA Receptors

  2008influential reference
• Rapid, bidirectional remodeling of synaptic NMDA receptor subunit composition by A-type K+ channel activity in hippocampal CA1 pyramidal neurons.

  2008cited by this paper
• LTP forms 1, 2 and 3: different mechanisms for the "long" in long-term potentiation.

  2007cited by this paper
• AMPAR exocytosis through NO modulation of PICK1.

  2007influential reference
• Deletion of glutamate receptor-A (GluR-A) AMPA receptor subunits impairs one-trial spatial memory.

  2007cited by this paper
• PICK1 and Phosphorylation of the Glutamate Receptor 2 (GluR2) AMPA Receptor Subunit Regulates GluR2 Recycling after NMDA Receptor-Induced Internalization

  2007cited by this paper
• Blind patch clamp recordings in embryonic and adult mammalian brain slices

  2006cited by this paper
• NMDA receptor function: subunit composition versus spatial distribution

  2006cited by this paper
• Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1.

  2006influential reference
• Relating NMDA Receptor Function to Receptor Subunit Composition: Limitations of the Pharmacological Approach

  2006cited by this paper
• Synaptic Currents in Anatomically Identified CA3 Neurons during Hippocampal Gamma Oscillations In Vitro

  2006cited by this paper
• NMDA receptors mediate calcium-dependent, bidirectional changes in dendritic PICK1 clustering.

  2006influential reference
• Protein kinase Mζ enhances excitatory synaptic transmission by increasing the number of active postsynaptic AMPA receptors

  2006influential reference
• Tonic and Phasic Nitric Oxide Signals in Hippocampal Long-Term Potentiation

  2006influential reference
• Extrasynaptic Membrane Trafficking Regulated by GluR1 Serine 845 Phosphorylation Primes AMPA Receptors for Long-term Potentiation*

  2006cited by this paper
• Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking.

  2005influential reference
• Dominant role of the GluR2 subunit in regulation of AMPA receptors by CaMKII

  2005cited by this paper
• Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF.

  2005influential reference
• Lack of NMDA Receptor Subtype Selectivity for Hippocampal Long-Term Potentiation

  2005influential reference
• S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors.

  2005influential reference
• A mechanism underlying AMPA receptor trafficking during cerebellar long-term potentiation.

  2005cited by this paper
• NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII.

  2005cited by this paper
• Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity

  2004cited by this paper
• LTP and LTD: an embarrassment of riches.

  2004cited by this paper
• Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory.

  2003cited by this paper
• A Juvenile form of Postsynaptic Hippocampal Long‐Term Potentiation in Mice Deficient for the AMPA Receptor Subunit GluR‐A

  2003influential reference
• A Within-Subjects, Within-Task Demonstration of Intact Spatial Reference Memory and Impaired Spatial Working Memory in Glutamate Receptor-A-Deficient Mice

  2003cited by this paper
• Impaired Regulation of Synaptic Strength in Hippocampal Neurons from GluR1‐Deficient Mice

  2003cited by this paper
• Short-term synaptic plasticity.

  2002cited by this paper
• Different calcium sources are narrowly tuned to the induction of different forms of LTP.

  2002cited by this paper
• Spatial memory dissociations in mice lacking GluR1

  2002cited by this paper
• Protein kinase Mζ is necessary and sufficient for LTP maintenance

  2002cited by this paper
• 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.

  2002influential reference
• New life in an old idea: The synaptic plasticity and memory hypothesis revisited

  2002cited by this paper
• Molecular dissection of hippocampal theta-burst pairing potentiation

  2002influential reference
• The molecular basis of CaMKII function in synaptic and behavioural memory

  2002cited by this paper
• Critical Postsynaptic Density 95/Disc Large/Zonula Occludens-1 Interactions by Glutamate Receptor 1 (GluR1) and GluR2 Required at Different Subcellular Sites

  2002cited by this paper
• NMDA receptor subunits: diversity, development and disease.

  2001cited by this paper
• Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons.

  2001cited by this paper
• Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons.

  2001influential reference
• Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.

  2001influential reference
• Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons

  2001cited by this paper
• PICK1 Targets Activated Protein Kinase Cα to AMPA Receptor Clusters in Spines of Hippocampal Neurons and Reduces Surface Levels of the AMPA-Type Glutamate Receptor Subunit 2

  2001cited by this paper
• PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.

  2000cited by this paper
• C-Terminal Truncation of NR2A Subunits Impairs Synaptic But Not Extrasynaptic Localization of NMDA Receptors

  2000cited by this paper
• Synaptic plasticity and memory: an evaluation of the hypothesis.

  2000cited by this paper
• Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

  2000cited by this paper
• Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction.

  2000influential reference
• The Incorporation of NMDA Receptors with a Distinct Subunit Composition at Nascent Hippocampal Synapses In Vitro

  1999cited by this paper
• Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation.

  1999cited by this paper
• Ca2+/calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors.

  1999cited by this paper
• Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning.

  1999influential reference
• Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons

  1998cited by this paper
• Modulation of AMPA receptor unitary conductance by synaptic activity

  1998influential reference
• Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation.

  1997influential reference
• Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.

  1997influential reference
• Specific Interaction of the PDZ Domain Protein PICK1 with the COOH Terminus of Protein Kinase C-α*

  1997cited by this paper
• Synaptic signaling by nitric oxide.

  1997cited by this paper
• Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains.

  1996cited by this paper
• Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons

  1996cited by this paper
• PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system

  1995cited by this paper
• Developmental and regional expression in the rat brain and functional properties of four NMDA receptors.

  1994cited by this paper
• Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.

  1994influential reference
• A synaptic model of memory: long-term potentiation in the hippocampus

  1993influential reference
• The synaptic activation of NMDA receptors and Ca2+ signalling in neurons.

  1992cited by this paper
• An Embarrassment of Riches

  1992cited by this paper
• Ca[2+]-calmodulin-dependent protein kinase II and intermediate filaments

  1992cited by this paper
• Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice.

  1992cited by this paper
• KN-62, 1-[N,O-Bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, a specific inhibitor of Ca[2+]/calmodulin-dependent protein kinase II

  1991influential reference
• KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

  1990influential reference
• Chelerythrine is a potent and specific inhibitor of protein kinase C.

  1990cited by this paper
• NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices.

  1989cited by this paper
• Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

  1989cited by this paper
• Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP.

  1989cited by this paper
• Persistent protein kinase activity underlying long-term potentiation

  1988cited by this paper
• Statistical Methods for Psychology

  1987influential reference
• Intracellular injections of EGTA block induction of hippocampal long-term potentiation

  1983cited by this paper
• Long‐term synaptic enhancement and short‐term potentiation in rat fascia dentata act through different mechanisms

  1982cited by this paper
• Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

  1973cited by this paper

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• Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP

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• Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition

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• Distinct effects of AMPAR subunit depletion on spatial memory

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• CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non‐associative learning

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• Distinct contributions of GluA1-containing AMPA receptors of different hippocampal subfields to salience processing, memory and impulse control

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• Sleep and homeostatic control of plasticity.

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• Genetic manipulations of AMPA glutamate receptors in hippocampal synaptic plasticity.

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• Deletion of AMPA receptor GluA1 subunit gene (Gria1) causes circadian rhythm disruption and aberrant responses to environmental cues

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  2013cites this paper
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