Dominant-negative VDAC1 mutants reveal oligomeric VDAC1 to be the active unit in mitochondria-mediated apoptosis.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Biochemical Journal

• Publication date

  2010-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1042/BJ20091338PMID 20420578
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• VDAC, a multi-functional mitochondrial protein regulating cell life and death.

  2010cited by this paper
• 6P.2VDAC1 cysteine residues: Topology and function in channel activity and apoptosis

  2010cited by this paper
• VDAC1 cysteine residues: topology and function in channel activity and apoptosis.

  2010cited by this paper
• The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins

  2009cited by this paper
• Crystal packing analysis of murine VDAC1 crystals in a lipidic environment reveals novel insights on oligomerization and orientation

  2009cited by this paper
• Voltage-dependent Anion Channel 1-based Peptides Interact with Bcl-2 to Prevent Antiapoptotic Activity*

  2009cited by this paper
• Voltage-dependent Anion Channel 1-based Peptides Interact with Hexokinase to Prevent Its Anti-apoptotic Activity*

  2009cited by this paper
• Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death

  2008cited by this paper
• Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

  2008cited by this paper
• Cytochrome c: functions beyond respiration

  2008cited by this paper
• Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents

  2008cited by this paper
• Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent Micelles

  2008cited by this paper
• Voltage‐dependent anion channel 1 is involved in endostatin‐induced endothelial cell apoptosis

  2008cited by this paper
• The crystal structure of mouse VDAC1 at 2.3 Å resolution reveals mechanistic insights into metabolite gating

  2008cited by this paper
• Structure of the human voltage-dependent anion channel

  2008cited by this paper
• Hexokinase-I Protection against Apoptotic Cell Death Is Mediated via Interaction with the Voltage-dependent Anion Channel-1

  2008cited by this paper
• Uncovering the role of VDAC in the regulation of cell life and death

  2008cited by this paper
• Mapping the ruthenium red-binding site of the voltage-dependent anion channel-1.

  2008cited by this paper
• The voltage dependent anion channel affects mitochondrial cholesterol distribution and function.

  2007cited by this paper
• Supramolecular assembly of VDAC in native mitochondrial outer membranes.

  2007cited by this paper
• Therapeutic effect of arsenic trioxide (As2O3) on cervical cancer in vitro and In vivo through apoptosis induction

  2007cited by this paper
• The supramolecular assemblies of voltage-dependent anion channels in the native membrane.

  2007cited by this paper
• The voltage-dependent anion channel

  2007cited by this paper
• NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL.

  2007cited by this paper
• The voltage-dependent anion channel (VDAC): function in intracellular signalling, cell life and cell death.

  2006cited by this paper
• Voltage-dependent anion channel (VDAC) as mitochondrial governator--thinking outside the box.

  2006cited by this paper
• Furanonaphthoquinones cause apoptosis of cancer cells by inducing the production of reactive oxygen species by the mitochondrial voltage-dependent anion channel

  2006cited by this paper
• The expression level of the voltage-dependent anion channel controls life and death of the cell.

  2006cited by this paper
• The voltage-dependent anion channel-1 modulates apoptotic cell death

  2005cited by this paper
• Oligomeric states of the voltage-dependent anion channel and cytochrome c release from mitochondria.

  2005cited by this paper
• Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide

  2004cited by this paper
• Subcellular localization of VDAC in mitochondria and ER in the cerebellum.

  2004cited by this paper
• VDAC: The channel at the interface between mitochondria and the cytosol

  2004cited by this paper
• Ruthenium red, inhibitor of mitochondrial Ca2+ uniporter, inhibits curcumin-induced apoptosis via the prevention of intracellular Ca2+ depletion and cytochrome c release.

  2003cited by this paper
• The mitochondrial voltage-dependent anion channel (VDAC) as a therapeutic target for initiating cell death.

  2003cited by this paper
• Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) Potassium Channels

  2002cited by this paper
• Formation of Functional Heterodimers between the TASK-1 and TASK-3 Two-pore Domain Potassium Channel Subunits*

  2002cited by this paper
• The voltage-dependent anion channel: an essential player in apoptosis.

  2002cited by this paper
• Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells

  2001cited by this paper
• Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function.

  2001cited by this paper
• VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release

  2001cited by this paper
• Chimers of two fused ADP/ATP carrier monomers indicate a single channel for ADP/ATP transport.

  2001cited by this paper
• Pivotal role of mitochondrial Ca(2+) in microcystin-induced mitochondrial permeability transition in rat hepatocytes.

  2001cited by this paper
• Block of Kcnk3 by Protons

  2001cited by this paper
• Electrophysiological Study of a Novel Large Pore Formed by Bax and the Voltage-dependent Anion Channel That Is Permeable to Cytochrome c *

  2000cited by this paper
• Mitochondria and cell death.

  2000cited by this paper
• Mitochondria as the central control point of apoptosis.

  2000cited by this paper
• Intracellular Ca2+ release mediates ursolic acid–induced apoptosis in human leukemic HL‐60 cells

  1997cited by this paper
• Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC.

  1986cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Visualizing VDAC1 in live cells using a tetracysteine tag

  2024cites this paper
• Interaction between BID and VDAC1 is required for mitochondrial demise and cell death in neurons

  2021cites this paper
• Cellular Interactome of Mitochondrial Voltage-Dependent Anion Channels: Oligomerization and Channel (Mis)Regulation.

  2021cites this paper
• VDAC and its interacting partners in plant and animal systems: an overview

  2020cites this paper
• A High Resolution Mass Spectrometry Study Reveals the Potential of Disulfide Formation in Human Mitochondrial Voltage-Dependent Anion Selective Channel Isoforms (hVDACs)

  2020cites this paper
• Mitochondrial channels: ion fluxes and more.

  2014cites this paper
• Mitochondrial ion channels as oncological targets

  2014cites this paper
• Targets and Strategies for the Mitochondrial Assault on Cancer

  2014cites this paper
• Oligomerization of the mitochondrial protein VDAC1: from structure to function and cancer therapy.

  2013cites this paper
• VDAC1: from structure to cancer therapy

  2012cites this paper
• The role of lipids in VDAC oligomerization.

  2012cites this paper
• Voltage dependent anion channel: Interaction with lipid membranes

  2012cites this paper
• A Frameshift Mutation of the Pro-Apoptotic VDAC1 Gene in Cancers with Microsatellite Instability

  2011cites this paper
• Multistep and multitask Bax activation.

  2010cites this paper
• Author ' s personal copy Multistep and multitask Bax activation

  2010cites this paper