Adjuvant hormonal therapy in premenopausal women with breast cancer

L. Smyth,C. Hudis

Published 2015 in Indian Journal of Medical and Paediatric Oncology

ABSTRACT

Duration of tamoxifen Tamoxifen use was truncated at 5 years based on the National Surgical Adjuvant Breast and Bowel Project (NSABP) B14 study. While this trial initially showed that 5 years of treatment was effective as compared to no-tamoxifen for hormone receptor positive, node negative breast cancer (mostly postmenopausal), a re-randomization of the treated cohort suggested that 10 years of therapy could be inferior to five.[9,10] This observation guided practice globally.

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