WAF1/CIP1 structural abnormalities do not contribute to cell cycle deregulation in ovarian cancer.

Mutations in the WAF1/CIP1 gene were not found in 36 ovarian carcinomas, including tumours with loss of heterozygosity at the WAF1/CIP1 locus and/or lacking p53 mutations. In addition, no association was demonstrable between a polymorphism in a conserved region of the WAF1/CIP1 gene and ovarian carcinoma.

• Publication year

  1996

• Venue

  British Journal of Cancer

• Publication date

  1996-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/bjc.1996.265PMID 8645586PMCID 2074480
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer.

  1995cited by this paper
• Polymorphisms and probable lack of mutation in the WAF1-CIP1 gene in colorectal cancer.

  1995cited by this paper
• Genetic disparity between morphologically benign cysts contiguous to ovarian carcinomas and solitary cystadenomas.

  1995cited by this paper
• Absence of somatic mutations in the coding region of the waf1/cip1 gene in human breast, lung and ovarian carcinomas - a polymorphism at codon-31.

  1995cited by this paper
• Induction of WAF1/CIP1 by a p53-independent pathway.

  1994cited by this paper
• Cell cycle control and cancer.

  1994cited by this paper
• Evidence of functional RB protein in epithelial ovarian carcinomas despite loss of heterozygosity at the RB locus.

  1994cited by this paper
• Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression.

  1994cited by this paper
• Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair

  1994cited by this paper
• The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

  1994cited by this paper
• Absence of WAF1 mutations in a variety of human malignancies.

  1994cited by this paper
• A cell cycle regulator potentially involved in genesis of many tumor types.

  1994cited by this paper
• A single nucleotide substitution at codon 31 (Ser/Arg) defines a polymorphism in a highly conserved region of the p53-inducible gene WAF1/CIP1.

  1994cited by this paper
• 3 distinct regions of chromosome-6 are targets of loss of heterozygosity in human ovarian carcinomas.

  1994cited by this paper
• WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

  1994cited by this paper
• Human epithelial ovarian cancer allelotype.

  1993cited by this paper
• Braking the cycle.

  1993cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993cited by this paper
• p21 is a universal inhibitor of cyclin kinases

  1993cited by this paper
• Frequent loss of heterozygosity on chromosome 6 in human ovarian carcinoma.

  1993cited by this paper
• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• p53 mutations in human cancers.

  1991cited by this paper

• p21 in Cancer Research

  2019cites this paper
• P21WAF1/Cip1 gene expression in primary human hepatocellular carcinoma and its relationship with P53 gene mutation

  2008cites this paper
• Polymorphisms in the p53 pathway

  2006cites this paper
• Genes Do Not Play a Role in Abnormal Cell Cycle Regulation in Breast Cancers Lacking p 53 Mutations 1

  2005cites this paper
• Evaluation of the cyclin-dependent kinase inhibitor p21Cip1 in epithelial ovarian tumors of low malignant potential and adenocarcinomas.

  2003cites this paper
• of low malignant potential and adenocarcinomas

  2003cites this paper
• Reduced retinoblastoma gene protein to Ki-67 ratio is an adverse prognostic indicator for ovarian adenocarcinoma patients.

  2003cites this paper
• Cyclin-dependent kinase-inhibitor 1 (CDKN1A) in the squamous epithelium of the oropharynx: possible implications of molecular biology and compartmentation.

  2001cites this paper
• p53 missense but not truncation mutations are associated with low levels of p21CIP1/WAF1 mRNA expression in primary human sarcomas

  2001cites this paper
• Polymorphism of the WAF1 gene is related to susceptibility to cervical cancer in Japanese women.

  2001cites this paper
• The p21 cyclin-dependent kinase inhibitor enhances the cytotoxic effect of cisplatin in human ovarian carcinoma cells

  2000cites this paper
• Evidence for a dose-response effect between p53 (but not p21WAF1/Cip1) protein concentrations, survival, and responsiveness in patients with epithelial ovarian cancer treated with platinum-based chemotherapy.

  2000cites this paper
• p21 (WAF1/CIP1) protein expression is associated with prolonged survival but not with p53 expression in epithelial ovarian carcinoma.

  2000cites this paper
• Topoisomerase II alpha: prognostic predictor and cell cycle marker in surface epithelial neoplasms of the ovary and peritoneum.

  2000cites this paper
• The p21(cip1/waf1) cyclin-dependent kinase inhibitor enhances the cytotoxic effect of cisplatin in human ovarian carcinoma cells.

  2000cites this paper
• p53 and WAF1 polymorphisms in Jewish‐Israeli women with epithelial ovarian cancer and its association with BRCA mutations

  2000cites this paper
• p53 and WAFl polymorphisms with epithelial ovarian cancer in Jewish-Israeli women and its association with BRCA mutations

  2000cites this paper
• A protective role for common p21WAF1/Cip1 polymorphisms in human ovarian cancer.

  1999cites this paper
• P21WAF1/Cip1 gene expression in primary human hepatocellular carcinoma and its relationship with P53 gene mutation.

  1999cites this paper
• Immunohistochemical markers of cell cycle control applied to ovarian and primary peritoneal surface epithelial neoplasms: p21(WAF1/CIP1) predicts survival and good response to platinin-based chemotherapy.

  1999cites this paper
• Lack of independent prognostic significance of p21 and p27 expression in advanced ovarian cancer: an immunohistochemical study.

  1999cites this paper
• Suppression of tumorigenicity in human ovarian cancer cell lines is controlled by a 2 cM fragment in chromosomal region 6q24-q25

  1999cites this paper
• Effects of enhancing p21waf1 on proliferation and expression of G1cyclins andCDKs in human breast cancer cells

  1999cites this paper
• WAF1 genotype and endometrial cancer susceptibility.

  1999cites this paper
• Altered WAF1 genes do not play a role in abnormal cell cycle regulation in breast cancers lacking p53 mutations.

  1997cites this paper
• Polymorphisms in P21CIP1/WAF1 are not correlated with TP53 status in sporadic ovarian tumours.

  1996cites this paper