Resolution of inflammation: targeting GPCRs that interact with lipids and peptides

Jenna L. Cash,L. Norling,M. Perretti

Published 2014 in Drug Discovery Today

ABSTRACT

There is a growing appreciation of the important role of resolution mediators in the successful termination of the inflammatory response. Here, we discuss the potential importance of the lipid and peptide proresolving mediators, in particular the resolvins and chemerin-derived peptides, which mediate their effects through specific G protein-coupled receptors (GPCRs).

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