Behavioral alterations induced by repeated saxitoxin exposure in drinking water

BackgroundBlooms of the saxitoxin-producing cyanobacterium Cylindrospermopsis raciborskii have been contaminating drinking water reservoirs in Brazil for many years. Although acute effects of saxitoxin intoxication are well known, chronic deleterious outcomes caused by repeated saxitoxin exposure still require further investigation. The aim of the present work is to investigate the effects of consumption of drinking water contaminated with C. raciborskii for 30 days on learning and memory processes in rats.MethodsThe effects of saxitoxin (3 or 9 μg/L STX equivalents) or cyanobacteria on behavior was determined using the open field habituation task, elevated plus maze anxiety model task, inhibitory avoidance task, and referential Morris water maze task.ResultsNo effects of saxitoxin consumption was observed on anxiety and motor exploratory parameters in the elevated plus maze and open field habituation tasks, respectively. However, groups treated with 9 μg/L STX equivalents displayed a decreased memory performance in the inhibitory avoidance and Morris water maze tasks.ConclusionsThese results suggest an amnesic effect of saxitoxin on aversive and spatial memories.

• Publication year

  2016

• Venue

  Journal of Venomous Animals and Toxins including Tropical Diseases

• Publication date

  2016-05-17

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1186/s40409-016-0072-9PMID 27190499PMCID 4869272
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oxidative stress in rats induced by consumption of saxitoxin contaminated drink water

  2014cited by this paper
• Saxitoxins induce cytotoxicity, genotoxicity and oxidative stress in teleost neurons in vitro.

  2014cited by this paper
• Zebrafish neurotoxicity from aphantoxins—cyanobacterial paralytic shellfish poisons (PSPs) from Aphanizomenon flos‐aquae DC‐1

  2013cited by this paper
• Participation of hippocampal cholinergic system in memory persistence for inhibitory avoidance in rats.

  2012cited by this paper
• Alterations of 3,4-dihydroxyphenylethylamine and its metabolite 3,4-dihydroxyphenylacetic produced in rat brain tissues after systemic administration of saxitoxin.

  2011cited by this paper
• Functional inactivation of the rat hippocampus disrupts avoidance of a moving object

  2011cited by this paper
• Acute Exposure to Microcystin-Producing Cyanobacterium Microcystis aeruginosa Alters Adult Zebrafish (Danio rerio) Swimming Performance Parameters

  2011cited by this paper
• Neurotoxins and Their Binding Areas on Voltage-Gated Sodium Channels

  2011cited by this paper
• First report about saxitoxins in freshwater fish Hoplias malabaricus through trophic exposure.

  2011cited by this paper
• Memory modulation.

  2011cited by this paper
• Neurotoxic cyanobacterial toxins.

  2010cited by this paper
• Molecular Specificity of Multiple Hippocampal Processes Governing Fear Extinction

  2010cited by this paper
• Effects of prenatal and postnatal exposure to a low dose of bisphenol A on behavior and memory in rats.

  2010cited by this paper
• Paralytic Shellfish Poisoning Toxin-Producing Cyanobacterium Aphanizomenon gracile in Northeast Germany

  2010cited by this paper
• Evidence for saxitoxins production by the cyanobacterium Aphanizomenon gracile in a French recreational water body

  2010cited by this paper
• Analyses of paralytic shellfish toxins and biomarkers in a southern Brazilian reservoir.

  2010cited by this paper
• Effects of systemic administration of saxitoxin on serotonin levels in some discrete rat brain regions.

  2009cited by this paper
• Lidocaine, tetrodotoxin and their effect on consolidation of spatial memory.

  2009cited by this paper
• Microcystin-induced oxidative stress in Laeonereis acuta (Polychaeta, Nereididae).

  2008cited by this paper
• BDNF is essential to promote persistence of long-term memory storage

  2008cited by this paper
• Application of precolumn oxidation HPLC method with fluorescence detection to evaluate saxitoxin levels in discrete brain regions of rats.

  2007cited by this paper
• Post-training reversible inactivation of the rat's basolateral amygdala interferes with hippocampus-dependent place avoidance memory in a time-dependent manner.

  2007cited by this paper
• The benefits and drawbacks of nicotine exposure in the cortex and hippocampus of old rats.

  2007cited by this paper
• Facilitatory effect of the intra-hippocampal pre-test administration of MT3 in the inhibitory avoidance task.

  2007cited by this paper
• Saxitoxin, a toxic marine natural product that targets a multitude of receptors.

  2006cited by this paper
• Harmful algal bloom toxins alter c-Fos protein expression in the brain of killifish, Fundulus heteroclitus.

  2006cited by this paper
• Retrieval induces hippocampal-dependent reconsolidation of spatial memory.

  2006influential reference
• First report of aphantoxins in China--waterblooms of toxigenic Aphanizomenon flos-aquae in Lake Dianchi.

  2006cited by this paper
• Estradiol valerate and tibolone: effects on memory.

  2006cited by this paper
• Toxic Cyanobacteria in Water : A guide to their public health consequences , monitoring and management

  2005cited by this paper
• Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on.

  2005cited by this paper
• Abnormal behaviours induced by chemical pollution: a review of the evidence and new challenges

  2004cited by this paper
• Accumulation of paralytic shellfish toxins (PST) from the cyanobacterium Aphanizomenon issatschenkoi by the cladoceran Daphnia magna.

  2004cited by this paper
• Quantitation of paralytic shellfish toxins using mouse brain synaptoneurosomes.

  2004cited by this paper
• From modulator to mediator: rapid effects of BDNF on ion channels

  2004cited by this paper
• Saxitoxin Blocks L-Type ICa

  2004cited by this paper
• Saxitoxin Is a Gating Modifier of hERG K+ Channels

  2003cited by this paper
• Dentate gyrus: alterations that occur with hippocampal injury.

  2003cited by this paper
• Cyanobacterial Neurotoxins from Southern Brazilian Freshwaters

  2003cited by this paper
• Role of adrenal stress hormones in forming lasting memories in the brain.

  2002cited by this paper
• Neurotrophin-evoked depolarization requires the sodium channel NaV1.9

  2002influential reference
• Learning and Memory

  2002cited by this paper
• Toxicokinetics and toxicodynamics of gonyautoxins after an oral toxin dose in cats.

  2002cited by this paper
• Simultaneous modulation of retrieval by dopaminergic D(1), beta-noradrenergic, serotonergic-1A and cholinergic muscarinic receptors in cortical structures of the rat.

  2001cited by this paper
• The toxins of Cyanobacteria.

  2001cited by this paper
• Simultaneous modulation of retrieval by dopaminergic D1, β-noradrenergic, serotonergic-1A and cholinergic muscarinic receptors in cortical structures of the rat

  2001cited by this paper
• THE FRESHWATER CYANOBACTERIUM PLANKTOTHRIX SP. FP1: MOLECULAR IDENTIFICATION AND DETECTION OF PARALYTIC SHELLFISH POISONING TOXINS

  2000cited by this paper
• Toxic cyanobacteria in water. A guide to their public health consequences, monitoring, and management

  2000cited by this paper
• An Overview of problems caused by toxic blue–green algae (cyanobacteria) in drinking and recreational water

  1999cited by this paper
• Toxic effects, pharmacokinetics and clearance of saxitoxin, a component of paralytic shellfish poison (PSP), in cats.

  1999cited by this paper
• Development of health alerts for cyanobacteria and related toxins in drinking water in South Australia

  1999cited by this paper
• The first evidence of paralytic shellfish toxins in the fresh water cyanobacterium Cylindrospermopsis raciborskii, isolated from Brazil.

  1999cited by this paper
• New saxitoxin analogues from the freshwater filamentous cyanobacterium Lyngbya wollei.

  1998cited by this paper
• Mechanisms for memory types differ

  1998cited by this paper
• Memory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structures.

  1997cited by this paper
• The toxins of cyanobacteria.

  1994cited by this paper
• A synaptic model of memory: long-term potentiation in the hippocampus

  1993cited by this paper
• Comparative study on paralytic shellfish toxin profiles of the dinoflagellate Gymnodinium catenatum from three different countries

  1993cited by this paper
• Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans.

  1992cited by this paper
• Learning and Memory

  1982cited by this paper
• Generic assignments, strain histories, and properties of pure cultures of cyanobacteria

  1979cited by this paper
• Isolation and culture of toxic strains of Anabaena flos-aquae (Lyngb.) de Bréb

  1964cited by this paper

• A Fresh Perspective on Cyanobacterial Paralytic Shellfish Poisoning Toxins: History, Methodology, and Toxicology

  2025cites this paper
• Electrochemical Investigation of DNA Interactions with Cyanobacterial Toxins: Cylindrospermopsin and Saxitoxin

  2025cites this paper
• Analyzing the neurotoxic effects of anatoxin-a and saxitoxin in zebrafish larvae.

  2024cites this paper
• The health risks of marine biotoxins associated with high seafood consumption: Looking beyond the single dose, single outcome paradigm with a view towards addressing the needs of coastal Indigenous populations in British Columbia

  2024cites this paper
• Understanding the Risks of Diffusion of Cyanobacteria Toxins in Rivers, Lakes, and Potable Water

  2023cites this paper
• Environmental Homeopathy: Homeopathic Potencies Regulate the Toxicity and Growth of Raphidiopsis raciborskii (Cyanobacteria) and can be Tracked Physico-Chemically. Part 1: Biological Results

  2023cites this paper
• Metal contamination and heat stress impair swimming behavior and acetylcholinesterase activity in embryo-larval stages of the Mediterranean mussel, Mytilus galloprovincialis.

  2022cites this paper
• A review of algal toxin exposures on reserved federal lands and among trust species in the United States

  2021cites this paper
• Shellfish contamination with lipophilic toxins and dietary exposure assessments from consumption of shellfish products in Shenzhen, China.

  2021cites this paper
• Effects of long-term low dose saxitoxin exposure on nerve damage in mice

  2021cites this paper
• Detección de biotoxinas en moluscos de venta al consumidor en la Comunidad de Madrid

  2020cites this paper
• Detección de biotoxinas en moluscos de venta al consumidor en la Comunidad de Madrid

  2020cites this paper
• Toxins as biological warfare agents

  2020cites this paper
• Cyanobacterial Toxins

  2019cites this paper
• Human Poisoning from Marine Toxins: Unknowns for Optimal Consumer Protection

  2018cites this paper