The metabolism of 2-carbon compounds related to glycine. I. Glyoxylic acid.

In a continuation of the search for intermediates involved in the condensation of the a-carbon atoms of 2 glycine molecules (l), investigations were carried out with ethanolamine-l-C13,2-C14 (C13H20H-C14H2NH2). It was considered possible that the serine synthesized from administered glycine2-Cl4 is, at first, labeled only in the a-carbon atom, the P-carbon atom being derived from unlabeled, endogenous sources of “formate.” If the ethanolamine formed from this serine (2) were capable of yielding a labeled lcarbon fragment, cr,/3-labeled serine would be produced. The results described below failed to support such a reaction scheme. It was shown, however, that a major reaction in the metabolism of ethanolamine is deamination, oxidation, and reamination to glycine.

• Publication year

  1953

• Venue

  Journal of Biological Chemistry

• Publication date

  1953-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0021-9258(19)52373-0PMID 13084672
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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